| Titre : | HBr−H2O2: a facile protocol for regioselective synthesis of bromohydrins and α-bromoketones and oxidation of benzylic/secondary alcohols to carbonyl compounds under mild aqueous conditions (2010) |
| Auteurs : | Rajendra D. Patil, Auteur ; Girdhar Joshi, Auteur ; Subbarayappa Adimurthy, Auteur |
| Type de document : | Article : texte imprimé |
| Dans : | Industrial & engineering chemistry research (Vol. 49 N° 17, Septembre 1, 2010) |
| Article en page(s) : | pp 8100–8105 |
| Note générale : | Chimie industrielle |
| Langues : | Anglais |
| Tags : | Bromohydrins Oxidation benzylic Mild aqueous. |
| Résumé : | HBr−H2O2 is efficiently activated in water under mild conditions, allowing the bromohydroxylation of various styrenes. HBr−H2O2 is more economic and easy to handle and offers sufficiently high regioselectivity (100%) for bromohydrin synthesis. Further activation of bromohydrin with a catalytic amount of HBr (50 mol %) and H2O2 in water affords α-bromoketones in moderate to good yields in a single step. Oxidation of benzylic/secondary alcohols to the corresponding carbonyl compounds has been achieved with the HBr (10 mol %) and H2O2 efficiently in aqueous dioxane under ambient conditions. |
| DEWEY : | 660 |
| ISSN : | 0888-5885 |
| En ligne : | http://pubs.acs.org/doi/abs/10.1021/ie100492r |
