| Titre : | Controlled release of bis(phosphonate) pharmaceuticals from cationic biodegradable polymeric matrices (2011) |
| Auteurs : | Konstantinos D. Demadis, Auteur ; Maria Paspalaki, Auteur ; Joanna Theodorou, Auteur |
| Type de document : | Article : texte imprimé |
| Dans : | Industrial & engineering chemistry research (Vol. 50 N° 9, Mai 2011) |
| Article en page(s) : | pp. 5873-5876 |
| Note générale : | Chimie industrielle |
| Langues : | Anglais |
| Tags : | Bis(phosphonate) Biodegradable Polymeric |
| Résumé : | Herein, the controlled release of etidronic acid (hydroxyethylidene-bis(phosphonic) acid), an important drug for osteoporotic conditions, immobilized onto cationic polymeric matrices, such as polyethyleneimine (PEI) or cationic inulin (CATIN) is reported. Several CATIN- and PEI-etidronate composites have been synthesized at various pH regions and characterized. Tablets with starch as the excipient containing the active ingredient (polymer-etidronate composite) were prepared, and the controlled release of etidronate was studied at aqueous solutions of pH 3 (to mimick the pH of the stomach) for 8 h. All studied composites showed a delayed etidronate release in the first 4 h, compared to the “control” (a tablet containing only starch and etidronic acid, without the polymer). |
| DEWEY : | 660 |
| ISSN : | 0888-5885 |
| En ligne : | http://pubs.acs.org/doi/abs/10.1021/ie102546g |
