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Titre :
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Data-driven feedforward control for electroporation mediated gene delivery in gene therapy (2011)
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Auteurs :
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Ruoting Yang, Auteur ;
Tzyh-Jong Tarn, Auteur ;
Mingjun Zhang, Auteur
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Type de document :
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Article : texte imprimé
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Dans :
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IEEE Transactions on control systems technology (Vol. 18 N° 4, Juillet 2010)
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Article en page(s) :
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pp. 935-943
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Note générale :
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Génie Aérospatial
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Langues :
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Anglais
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Index. décimale :
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629.1
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Tags :
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Data-driven Electroporation Feedforward Gene delivery therapy
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Résumé :
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This brief proposes a novel data-driven feedforward control mechanism to regulate micro/nanoscale systems subject to insufficient measurements. The theoretical framework integrates data-driven planning and formulates a feedforward controller, which is successfully applied to an electroporation mediated gene delivery problem in gene therapy. Nonlinear dynamics modeling and analysis of the biological cell electroporation process, especially hysteresis and nonlinear jump phenomenon, are discussed. Simulation results demonstrate that the proposed control outperforms existing methods in the open literature.
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DEWEY :
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629.1
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ISSN :
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1063-6536
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En ligne :
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http://ieeexplore.ieee.org/xpl/freeabs_all.jsp?arnumber=5286233
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