[article] 
inIndustrial & engineering chemistry research > Vol. 50 N° 20 (Octobre 2011) . - pp. 11667–11676

Titre :	Purification of forskolin by adsorptive separation using functionalized polymer bearing specific ligands designed by molecular simulation
Type de document :	texte imprimé
Auteurs :	Leena P. Devendra, Auteur ; Vilas G. Gaikar, Auteur
Année de publication :	2011
Article en page(s) :	pp. 11667–11676
Note générale :	Chimie industrielle
Langues :	Anglais (eng)
Mots-clés :	Adsorption Molecular modeling
Résumé :	The adsorption of forskolin and its analogues has been studied, a priori, by molecular modeling to design a suitable adsorbent for selective adsorption of forskolin from a complex extract. Ligands selective for forskolin have been designed on the basis of two-point attachments with forskolin so as to have desired selectivity. Dynamic adsorption and desorption experiments were conducted to establish the optimum parameters for the purification process using a functionalized polymer. After a single adsorption and desorption cycle, the purity of the forskolin increased to 98% using phenyl glycine-p-sulfonic acid substituted polystyrene as a functionalized polymer. Experimental verification of the selectivity of the ligand toward forskolin was successfully achieved.
DEWEY :	660
ISSN :	0888-5885
En ligne :	http://pubs.acs.org/doi/abs/10.1021/ie2004175

[article] Purification of forskolin by adsorptive separation using functionalized polymer bearing specific ligands designed by molecular simulation [texte imprimé] / Leena P. Devendra, Auteur ; Vilas G. Gaikar, Auteur . - 2011 . - pp. 11667–11676.
Chimie industrielle
Langues : Anglais (eng)
in Industrial & engineering chemistry research > Vol. 50 N° 20 (Octobre 2011) . - pp. 11667–11676

Mots-clés :	Adsorption Molecular modeling
Résumé :	The adsorption of forskolin and its analogues has been studied, a priori, by molecular modeling to design a suitable adsorbent for selective adsorption of forskolin from a complex extract. Ligands selective for forskolin have been designed on the basis of two-point attachments with forskolin so as to have desired selectivity. Dynamic adsorption and desorption experiments were conducted to establish the optimum parameters for the purification process using a functionalized polymer. After a single adsorption and desorption cycle, the purity of the forskolin increased to 98% using phenyl glycine-p-sulfonic acid substituted polystyrene as a functionalized polymer. Experimental verification of the selectivity of the ligand toward forskolin was successfully achieved.
DEWEY :	660
ISSN :	0888-5885
En ligne :	http://pubs.acs.org/doi/abs/10.1021/ie2004175