| Titre : | Purification of forskolin by adsorptive separation using functionalized polymer bearing specific ligands designed by molecular simulation (2011) |
| Auteurs : | Leena P. Devendra, Auteur ; Vilas G. Gaikar, Auteur |
| Type de document : | Article : texte imprimé |
| Dans : | Industrial & engineering chemistry research (Vol. 50 N° 20, Octobre 2011) |
| Article en page(s) : | pp. 11667–11676 |
| Note générale : | Chimie industrielle |
| Langues : | Anglais |
| Tags : | Adsorption Molecular modeling |
| Résumé : | The adsorption of forskolin and its analogues has been studied, a priori, by molecular modeling to design a suitable adsorbent for selective adsorption of forskolin from a complex extract. Ligands selective for forskolin have been designed on the basis of two-point attachments with forskolin so as to have desired selectivity. Dynamic adsorption and desorption experiments were conducted to establish the optimum parameters for the purification process using a functionalized polymer. After a single adsorption and desorption cycle, the purity of the forskolin increased to 98% using phenyl glycine-p-sulfonic acid substituted polystyrene as a functionalized polymer. Experimental verification of the selectivity of the ligand toward forskolin was successfully achieved. |
| DEWEY : | 660 |
| ISSN : | 0888-5885 |
| En ligne : | http://pubs.acs.org/doi/abs/10.1021/ie2004175 |
