| Titre : | Novel semi - interpenetrating microspheres of dextran - grafted - acrylamide and poly (vinyl alcohol) for controlled release of abacavir sulfate (2011) |
| Auteurs : | Anita G. Sullad, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur |
| Type de document : | Article : texte imprimé |
| Dans : | Industrial & engineering chemistry research (Vol. 50 N° 21, Novembre 2011) |
| Article en page(s) : | pp. 11778–11784 |
| Note générale : | Chimie industrielle |
| Langues : | Anglais |
| Tags : | Microspheres Dextran |
| Résumé : | A novel drug delivery system using semi-interpenetrating (semi-IPN) microspheres of dextran-grafted-acrylamide (Dex-g-AAm) and poly(vinyl alcohol) (PVA) was prepared in the size range of 80–100 μm by emulsion cross-linking for investigating controlled release (CR) of an anti-HIV agent, abacavir sulfate. The graft copolymer was confirmed by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The microspheres were characterized for morphology, swelling, and in vitro release of abacavir sulfate in pH 1.2 and 7.4 buffer media to display the effect of drug release in acidic and alkaline conditions. The kinetics of in vitro release was analyzed using the empirical equations to understand the nature of release mechanism. |
| DEWEY : | 660 |
| ISSN : | 0888-5885 |
| En ligne : | http://pubs.acs.org/doi/abs/10.1021/ie2006438 |
