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A review on terpenes as skin penetration enhancers in transdermal drug delivery / Perry Fung Chye Lim in The journal of essential oil research, Vol. 21 N° 5 (Septembre/Octobre 2009) 

Public ISBD [article]  in The journal of essential oil research > Vol. 21 N° 5 (Septembre/Octobre 2009) . - pp. 423- 428 Titre : A review on terpenes as skin penetration enhancers in transdermal drug delivery Type de document : texte imprimé Auteurs : Perry Fung Chye Lim, Auteur ; Xiang Yang Liu, Auteur ; Sui Yung Chan, Auteur Article en page(s) : pp. 423- 428 Note générale : Génie Chimique Langues : Anglais (eng) Mots-clés : Skin  penetration  Transdermal  drug  delivery  Penetration  enhancers  Terpenes Index. décimale : 646 Résumé : The skin itself hinders the widespread use of transdermal drug delivery (TDD) for administration of medication. Despite the different strategies devised and employed to reversibly overcome the skin barrier, this non-invasive delivery mode is restricted to potent, low molar mass therapeutic agents. The use of chemical penetration enhancers is the conventional approach to modify the skin structure and lower its resistance for increased drug permeation. Over the years, extensive screening and testing have identified different classes of chemicals as potential adjuvants. Among these, terpenes (constituents of plant essential oils) have been widely investigated as skin penetration enhancers for both hydrophilic and hydrophobic drugs. In particular, monoterpenes were generally more efficacious probably due to their small molecular sizes. The main mechanisms of action of terpenes on the skin as determined by several analytical techniques were lipid extraction and phase separation. Terpenes such as limonene and menthol in experimental patch formulations were demonstrated to be safe on the skin and effective in improving drug delivery across the skin. DEWEY : 665 ISSN : 1041-2905 En ligne : http://www.jeoronline.com/archive/detail/42#top [article] A review on terpenes as skin penetration enhancers in transdermal drug delivery [texte imprimé] / Perry Fung Chye Lim, Auteur ; Xiang Yang Liu, Auteur ; Sui Yung Chan, Auteur . - pp. 423- 428. Génie Chimique Langues : Anglais (eng) in The journal of essential oil research > Vol. 21 N° 5 (Septembre/Octobre 2009) . - pp. 423- 428 Mots-clés : Skin  penetration  Transdermal  drug  delivery  Penetration  enhancers  Terpenes Index. décimale : 646 Résumé : The skin itself hinders the widespread use of transdermal drug delivery (TDD) for administration of medication. Despite the different strategies devised and employed to reversibly overcome the skin barrier, this non-invasive delivery mode is restricted to potent, low molar mass therapeutic agents. The use of chemical penetration enhancers is the conventional approach to modify the skin structure and lower its resistance for increased drug permeation. Over the years, extensive screening and testing have identified different classes of chemicals as potential adjuvants. Among these, terpenes (constituents of plant essential oils) have been widely investigated as skin penetration enhancers for both hydrophilic and hydrophobic drugs. In particular, monoterpenes were generally more efficacious probably due to their small molecular sizes. The main mechanisms of action of terpenes on the skin as determined by several analytical techniques were lipid extraction and phase separation. Terpenes such as limonene and menthol in experimental patch formulations were demonstrated to be safe on the skin and effective in improving drug delivery across the skin. DEWEY : 665 ISSN : 1041-2905 En ligne : http://www.jeoronline.com/archive/detail/42#top