Phytochemical and toxicological evaluations of the essential oil from the bark of aniba canellila (H.B.K.) mez. / P.J.C. Sousa in The journal of essential oil research, Vol. 21 N° 4 (Juillet/Août 2009)  

Public ISBD [article]  inThe journal of essential oil research > Vol. 21 N° 4 (Juillet/Août 2009) . - pp. 381-384 Titre : Phytochemical and toxicological evaluations of the essential oil from the bark of aniba canellila (H.B.K.) mez. Type de document : texte imprimé Auteurs : P.J.C. Sousa, Auteur ; J. S. Araujo, Auteur ; L.L.S. Pereira, Auteur Article en page(s) : pp. 381-384 Note générale : Génie Chimique Langues : Anglais (eng) Mots-clés : Aniba canellila Lauraceae Essential oil composition 1-nitro-2-phenylethane Methyl eugenol Index. décimale : 646 Résumé : Due to its therapeutic action, the phytochemical study of the essential oil of Aniba canelilla H.B.K Mez. (Lauraceae) and its toxicological preclinical trial were evaluated. The essential oil extracted from the bark (OEAC) yielded 1.0% and the major constituents were 1-nitro-2-phenylethane (52.9%) and methyl eugenol (38.7%), both identified by GC/ MS and GC-FID. The observed LD50 (oral) was 720 ± 66.4 mg/kg. The doses used in the subacute toxicity study (1/10 and 1/20 of the LD50) were administered in rats for 30 days, and the biochemical (glucose, urea, creatinine, triglycerides, cholesterol, glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase and alkaline phosphatase) and hematological (erythrocytes, leukocytes and platelets counts, blood hemoglobin concentration, hematocrit and mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration) parameters were observed. The results suggested that the A. canellila oil presented low toxicity in rats, according to the used dosages. DEWEY : 665 ISSN : 1041-2905 En ligne : http://www.jeoronline.com/archive/detail/42#top [article] Phytochemical and toxicological evaluations of the essential oil from the bark of aniba canellila (H.B.K.) mez. [texte imprimé] / P.J.C. Sousa, Auteur ; J. S. Araujo, Auteur ; L.L.S. Pereira, Auteur . - pp. 381-384. Génie Chimique Langues : Anglais (eng) in The journal of essential oil research > Vol. 21 N° 4 (Juillet/Août 2009) . - pp. 381-384 Mots-clés : Aniba canellila Lauraceae Essential oil composition 1-nitro-2-phenylethane Methyl eugenol Index. décimale : 646 Résumé : Due to its therapeutic action, the phytochemical study of the essential oil of Aniba canelilla H.B.K Mez. (Lauraceae) and its toxicological preclinical trial were evaluated. The essential oil extracted from the bark (OEAC) yielded 1.0% and the major constituents were 1-nitro-2-phenylethane (52.9%) and methyl eugenol (38.7%), both identified by GC/ MS and GC-FID. The observed LD50 (oral) was 720 ± 66.4 mg/kg. The doses used in the subacute toxicity study (1/10 and 1/20 of the LD50) were administered in rats for 30 days, and the biochemical (glucose, urea, creatinine, triglycerides, cholesterol, glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase and alkaline phosphatase) and hematological (erythrocytes, leukocytes and platelets counts, blood hemoglobin concentration, hematocrit and mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration) parameters were observed. The results suggested that the A. canellila oil presented low toxicity in rats, according to the used dosages. DEWEY : 665 ISSN : 1041-2905 En ligne : http://www.jeoronline.com/archive/detail/42#top

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