Documents disponibles écrits par cet auteur

Identification and quantification of related impurities in 2-chloroethyl phenyl sulfide for industrial use / Qiao, Jun-Qin in Industrial & engineering chemistry research, Vol. 49 N° 2 (Janvier 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 2 (Janvier 2010) . - pp 443–447 Titre : Identification and quantification of related impurities in 2-chloroethyl phenyl sulfide for industrial use Type de document : texte imprimé Auteurs : Qiao, Jun-Qin, Auteur ; Bao, Yan-Chu, Auteur ; Yang, Ji-Hong, Auteur Année de publication : 2010 Article en page(s) : pp 443–447 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Chloroethyl  Phenyl  Sulfide. Résumé : A combination of gas chromatography and mass spectrometry (GC-MS) was applied to separate and identify the relative substances in 2-chloroethyl phenyl sulfide (CEPS), an industrial intermediate formed in the synthesis of sulfinpyrazone. Six impurities, including 1,2-dichloroethane, thiophenol, diethylmalonate, tributylamine, diphenyl disulfide, and 1,2-dithiophenylethane, were verified. According to the production technique, the sources of all of these related impurities were analyzed, and some practical suggestions are put forward for their removal from or avoidance in CEPS. Furthermore, a technique involving high-performance liquid chromatography with UV detection (HPLC-UV) was developed to separate and determine thiophenol, the key impurity in CEPS. A linear standard curve was obtained for thiophenol in concentrations between 2.65 × 10−4 and 0.106 mg mL−1, and the detection limit of thiophenol was 1.32 × 10−4 mg mL−1. Excellent precision and accuracy were shown from the method validation, with relative standard deviations (RSDs) of less than 1.5% for both intra- and interday measurements, and recoveries between 95.4% and 97.0%. Based on the above merits, the proposed procedures of GC-MS and HPLC-UV can provide specific information on the impurities in CEPS, and therefore, these methods can be well applied to quality control in the industrial production of CEPS. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9014167 [article] Identification and quantification of related impurities in 2-chloroethyl phenyl sulfide for industrial use [texte imprimé] / Qiao, Jun-Qin, Auteur ; Bao, Yan-Chu, Auteur ; Yang, Ji-Hong, Auteur . - 2010 . - pp 443–447. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 2 (Janvier 2010) . - pp 443–447 Mots-clés : Chloroethyl  Phenyl  Sulfide. Résumé : A combination of gas chromatography and mass spectrometry (GC-MS) was applied to separate and identify the relative substances in 2-chloroethyl phenyl sulfide (CEPS), an industrial intermediate formed in the synthesis of sulfinpyrazone. Six impurities, including 1,2-dichloroethane, thiophenol, diethylmalonate, tributylamine, diphenyl disulfide, and 1,2-dithiophenylethane, were verified. According to the production technique, the sources of all of these related impurities were analyzed, and some practical suggestions are put forward for their removal from or avoidance in CEPS. Furthermore, a technique involving high-performance liquid chromatography with UV detection (HPLC-UV) was developed to separate and determine thiophenol, the key impurity in CEPS. A linear standard curve was obtained for thiophenol in concentrations between 2.65 × 10−4 and 0.106 mg mL−1, and the detection limit of thiophenol was 1.32 × 10−4 mg mL−1. Excellent precision and accuracy were shown from the method validation, with relative standard deviations (RSDs) of less than 1.5% for both intra- and interday measurements, and recoveries between 95.4% and 97.0%. Based on the above merits, the proposed procedures of GC-MS and HPLC-UV can provide specific information on the impurities in CEPS, and therefore, these methods can be well applied to quality control in the industrial production of CEPS. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9014167