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Article high silica zeolites as an alternative to weak base adsorbents in succinic acid recovery / Efe, Cagri in Industrial & engineering chemistry research, Vol. 49 N° 4 (Fevrier 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 4 (Fevrier 2010) . - pp 1837–1843 Titre : Article high silica zeolites as an alternative to weak base adsorbents in succinic acid recovery Type de document : texte imprimé Auteurs : Efe, Cagri, Auteur ; Van der Wielen, Luuk A. M., Auteur ; Straathof, Adrie J. J., Auteur Année de publication : 2010 Article en page(s) : pp 1837–1843 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : High  silica  zeolites  Succinic  acid. Résumé : Initial studies were performed on succinic acid adsorption from aqueous solutions by zeolite powders. CVB-28014 (high-silica ZSM-5) showed higher equilibrium loadings (up to 0.16 g/g) than CBV-901 and CP811C-300, and was used for follow up studies. In the presence of Na+ counterions, the succinic acid adsorption decreased in parallel with the succinic acid dissociation, but the adsorbent also showed some affinity toward sodium hydrogensuccinate with selectivities in the range 10−20 toward succinic acid. The presence of acetic acid resulted in lower succinic acid loadings but the capacities remained sufficient for efficient recovery. The selectivity between succinic acid and acetic acid ranged from 1 to 6. Increasing the temperature to 70 °C reduced the equilibrium loadings, but in ethanol the succinic acid loadings showed a more significant drop. Therefore, regeneration might be achieved by using an adsorption-competitive solvent like ethanol. The current results suggest that this may lead to an attractive option for the recovery of succinic acid from fermentation media. Hydrophobic rather than ionic interactions are used, thus avoiding regeneration involving acid and base and the associated waste salt production. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie901110b [article] Article high silica zeolites as an alternative to weak base adsorbents in succinic acid recovery [texte imprimé] / Efe, Cagri, Auteur ; Van der Wielen, Luuk A. M., Auteur ; Straathof, Adrie J. J., Auteur . - 2010 . - pp 1837–1843. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 4 (Fevrier 2010) . - pp 1837–1843 Mots-clés : High  silica  zeolites  Succinic  acid. Résumé : Initial studies were performed on succinic acid adsorption from aqueous solutions by zeolite powders. CVB-28014 (high-silica ZSM-5) showed higher equilibrium loadings (up to 0.16 g/g) than CBV-901 and CP811C-300, and was used for follow up studies. In the presence of Na+ counterions, the succinic acid adsorption decreased in parallel with the succinic acid dissociation, but the adsorbent also showed some affinity toward sodium hydrogensuccinate with selectivities in the range 10−20 toward succinic acid. The presence of acetic acid resulted in lower succinic acid loadings but the capacities remained sufficient for efficient recovery. The selectivity between succinic acid and acetic acid ranged from 1 to 6. Increasing the temperature to 70 °C reduced the equilibrium loadings, but in ethanol the succinic acid loadings showed a more significant drop. Therefore, regeneration might be achieved by using an adsorption-competitive solvent like ethanol. The current results suggest that this may lead to an attractive option for the recovery of succinic acid from fermentation media. Hydrophobic rather than ionic interactions are used, thus avoiding regeneration involving acid and base and the associated waste salt production. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie901110b

Assessment of options for selective 1-butanol recovery from aqueous solution / Arjan Oudshoorn in Industrial & engineering chemistry research, Vol. 48 N° 15 (Août 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N° 15 (Août 2009) . - pp. 7325–7336 Titre : Assessment of options for selective 1-butanol recovery from aqueous solution Type de document : texte imprimé Auteurs : Arjan Oudshoorn, Auteur ; Van der Wielen, Luuk A. M., Auteur ; Straathof, Adrie J. J., Auteur Année de publication : 2009 Article en page(s) : pp. 7325–7336 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : 1-butanol  Butanol  recovery  methodsAqueous  fermentation  Efficient  recovery Résumé : The microbial production of 1-butanol occurs in aqueous fermentation broth, with up to ∼20 g/L of product. Efficient recovery of butanol from this dilute aqueous phase determines, to a large extent, the efficiency of the production process. Starting from the thermodynamic (phase) properties of butanol and water systems, this paper presents a structured approach to determine the key characteristics of various butanol recovery methods. Analysis of reported separations, combined with fundamental phase properties, has resulted in both the characterization of the selectivity of recovery and estimations of the energy requirement during product recovery for a variety of recovery methods. Energy-efficient systems for the recovery of butanol from aqueous solution are pervaporation- and adsorption-based techniques. The applied method predicts the recovery energy requirement for both techniques to be <4 MJ/kg of butanol, which, on an energy basis, is similar to ∼10% of the internal combustion energy of butanol. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900537w [article] Assessment of options for selective 1-butanol recovery from aqueous solution [texte imprimé] / Arjan Oudshoorn, Auteur ; Van der Wielen, Luuk A. M., Auteur ; Straathof, Adrie J. J., Auteur . - 2009 . - pp. 7325–7336. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 15 (Août 2009) . - pp. 7325–7336 Mots-clés : 1-butanol  Butanol  recovery  methodsAqueous  fermentation  Efficient  recovery Résumé : The microbial production of 1-butanol occurs in aqueous fermentation broth, with up to ∼20 g/L of product. Efficient recovery of butanol from this dilute aqueous phase determines, to a large extent, the efficiency of the production process. Starting from the thermodynamic (phase) properties of butanol and water systems, this paper presents a structured approach to determine the key characteristics of various butanol recovery methods. Analysis of reported separations, combined with fundamental phase properties, has resulted in both the characterization of the selectivity of recovery and estimations of the energy requirement during product recovery for a variety of recovery methods. Energy-efficient systems for the recovery of butanol from aqueous solution are pervaporation- and adsorption-based techniques. The applied method predicts the recovery energy requirement for both techniques to be <4 MJ/kg of butanol, which, on an energy basis, is similar to ∼10% of the internal combustion energy of butanol. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900537w

Conceptual evaluation of integrated process configurations for the recovery of i-phenylalanine product crystals during fermentation / Cuellar, Maria C. in Industrial & engineering chemistry research, Vol. 49 N° 2 (Janvier 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 2 (Janvier 2010) . - pp 682–689 Titre : Conceptual evaluation of integrated process configurations for the recovery of i-phenylalanine product crystals during fermentation Type de document : texte imprimé Auteurs : Cuellar, Maria C., Auteur ; Straathof, Adrie J. J., Auteur ; Van de Sandt, Emile J. A. X., Auteur Année de publication : 2010 Article en page(s) : pp 682–689 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Amino  acid  Anhydrate  crystals. Résumé : The production of the amino acid l-phenylalanine (Phe) by fermentation is in many cases limited by the tight regulation of the microbial pathway leading to Phe synthesis. One way of circumventing feedback repression is to remove the product from the vicinity of the micro-organism as soon as it is being formed. In the case of Phe, techniques like adsorption and extraction have been applied with this aim. In these processes, however, additional recovery steps are required in order to obtain the product as anhydrate crystals, which is its commercial form. In this work we evaluated conceptually the recovery of Phe anhydrate crystals during a fermentation process. The product recovery consisted of water removal by reverse osmosis, crystallization, and recycle of the mother liquor either to the fermenter, to the water removal unit or to both. By maintaining the Phe mass fraction in the fermenter at about 17 g kg−1 the fermentation productivity increased according to the calculations from 0.66 g kg−1 h−1, without product removal, to 1.07 g kg−1 h−1, with product removal, where about 70% of the produced Phe was directly recovered as anhydrate crystals. By means of a simplified economic model it was shown that the membranes required for cell retention and water removal have much more impact on the economic performance of the process than the consumption of raw materials, and therefore, the favored recycling option for the mother liquor is to the water removal unit DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie901007g [article] Conceptual evaluation of integrated process configurations for the recovery of i-phenylalanine product crystals during fermentation [texte imprimé] / Cuellar, Maria C., Auteur ; Straathof, Adrie J. J., Auteur ; Van de Sandt, Emile J. A. X., Auteur . - 2010 . - pp 682–689. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 2 (Janvier 2010) . - pp 682–689 Mots-clés : Amino  acid  Anhydrate  crystals. Résumé : The production of the amino acid l-phenylalanine (Phe) by fermentation is in many cases limited by the tight regulation of the microbial pathway leading to Phe synthesis. One way of circumventing feedback repression is to remove the product from the vicinity of the micro-organism as soon as it is being formed. In the case of Phe, techniques like adsorption and extraction have been applied with this aim. In these processes, however, additional recovery steps are required in order to obtain the product as anhydrate crystals, which is its commercial form. In this work we evaluated conceptually the recovery of Phe anhydrate crystals during a fermentation process. The product recovery consisted of water removal by reverse osmosis, crystallization, and recycle of the mother liquor either to the fermenter, to the water removal unit or to both. By maintaining the Phe mass fraction in the fermenter at about 17 g kg−1 the fermentation productivity increased according to the calculations from 0.66 g kg−1 h−1, without product removal, to 1.07 g kg−1 h−1, with product removal, where about 70% of the produced Phe was directly recovered as anhydrate crystals. By means of a simplified economic model it was shown that the membranes required for cell retention and water removal have much more impact on the economic performance of the process than the consumption of raw materials, and therefore, the favored recycling option for the mother liquor is to the water removal unit DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie901007g

Conceptual process design of integrated fermentation, deacylation, and crystallization in the production of β-lactam antibiotics / Carol A. Roa Engel in Industrial & engineering chemistry research, Vol. 48 N° 9 (Mai 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N° 9 (Mai 2009) . - pp. 4352–4364 Titre : Conceptual process design of integrated fermentation, deacylation, and crystallization in the production of β-lactam antibiotics Type de document : texte imprimé Auteurs : Carol A. Roa Engel, Auteur ; Straathof, Adrie J. J., Auteur ; Walter M. van Gulik, Auteur Année de publication : 2009 Article en page(s) : pp. 4352–4364 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : β-lactam  nuclei  production  Fermentation  Enzymatic  deacylation Résumé : Integration of fermentation and downstream steps is required to improve the sustainability of industrial biotechnology processes. In this context, a new integrated process for β-lactam nuclei production is proposed, which has been theoretically investigated and conceptually designed. This process is an integration of fermentation and enzymatic deacylation of adipyl-7-aminodeacetoxycephalosporanic acid (adADCA) in one reactor producing 7-aminodeacetoxycephalosporanic acid (ADCA) directly from glucose. Although the deacylation equilibrium is unfavorable at the fermentation pH, it is pulled to completion because ADCA starts to crystallize and the liberated side chain, adipic acid (AA), is consumed by the fermentation. Therefore the integrated process requires much less AA than the nonintegrated process. In addition, the new process will lead to a reduction in number of downstream processing units, should avoid the use of acids and bases for pH shifts, and might lead to a reduction in waste salts production. A conceptual process was designed including an economic and technical analysis. The design goal was to produce 2000 tons/year of ADCA of 99% purity. Rigorous simulations were performed to evaluate different process options. Among the economic advantages of the new integrated process are 13.4% lower capital investments and 7.8% lower manufacturing costs. An analogous process for 6-aminopenicillanic acid (APA) is not feasible due to chemical degradation of this product. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie801335r [article] Conceptual process design of integrated fermentation, deacylation, and crystallization in the production of β-lactam antibiotics [texte imprimé] / Carol A. Roa Engel, Auteur ; Straathof, Adrie J. J., Auteur ; Walter M. van Gulik, Auteur . - 2009 . - pp. 4352–4364. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 9 (Mai 2009) . - pp. 4352–4364 Mots-clés : β-lactam  nuclei  production  Fermentation  Enzymatic  deacylation Résumé : Integration of fermentation and downstream steps is required to improve the sustainability of industrial biotechnology processes. In this context, a new integrated process for β-lactam nuclei production is proposed, which has been theoretically investigated and conceptually designed. This process is an integration of fermentation and enzymatic deacylation of adipyl-7-aminodeacetoxycephalosporanic acid (adADCA) in one reactor producing 7-aminodeacetoxycephalosporanic acid (ADCA) directly from glucose. Although the deacylation equilibrium is unfavorable at the fermentation pH, it is pulled to completion because ADCA starts to crystallize and the liberated side chain, adipic acid (AA), is consumed by the fermentation. Therefore the integrated process requires much less AA than the nonintegrated process. In addition, the new process will lead to a reduction in number of downstream processing units, should avoid the use of acids and bases for pH shifts, and might lead to a reduction in waste salts production. A conceptual process was designed including an economic and technical analysis. The design goal was to produce 2000 tons/year of ADCA of 99% purity. Rigorous simulations were performed to evaluate different process options. Among the economic advantages of the new integrated process are 13.4% lower capital investments and 7.8% lower manufacturing costs. An analogous process for 6-aminopenicillanic acid (APA) is not feasible due to chemical degradation of this product. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie801335r

Limits of operation for the integration of water removal by membranes and crystallization of l-phenylalanine / Cuellar, Maria C. in Industrial & engineering chemistry research, Vol. 48 N°3 (Février 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N°3 (Février 2009) . - p. 1566–1573 Titre : Limits of operation for the integration of water removal by membranes and crystallization of l-phenylalanine Type de document : texte imprimé Auteurs : Cuellar, Maria C., Auteur ; Simone N. Herreilers, Auteur ; Straathof, Adrie J. J., Auteur Année de publication : 2009 Article en page(s) : p. 1566–1573 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : water  Crystallization  process  Phenylalanine Résumé : Integration of crystallization and water removal using membrane technology is being used as a means to improve control over supersaturation generation and, consequently, to improve crystal quality. However, it is not clear yet how water removal, which has a limited window of operation, can be combined with crystallization in case of occurrence of several crystal forms (and, therefore, also a limited window of operation). In this work we evaluated the use of nanofiltration and reverse osmosis for water removal to achieve selective crystallization of l-phenylalanine anhydrate from aqueous solution. Water removal and crystallization were first studied separately, and models were used to define the limits of operation for the coupled system so that the target crystal form and production rate could be achieved. A narrow window of operation was obtained, and it was shown that practical implementation can be difficult due to operation near the limits of the window of operation. Possibilities for widening the window of operation are briefly discussed. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie8012659 [article] Limits of operation for the integration of water removal by membranes and crystallization of l-phenylalanine [texte imprimé] / Cuellar, Maria C., Auteur ; Simone N. Herreilers, Auteur ; Straathof, Adrie J. J., Auteur . - 2009 . - p. 1566–1573. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N°3 (Février 2009) . - p. 1566–1573 Mots-clés : water  Crystallization  process  Phenylalanine Résumé : Integration of crystallization and water removal using membrane technology is being used as a means to improve control over supersaturation generation and, consequently, to improve crystal quality. However, it is not clear yet how water removal, which has a limited window of operation, can be combined with crystallization in case of occurrence of several crystal forms (and, therefore, also a limited window of operation). In this work we evaluated the use of nanofiltration and reverse osmosis for water removal to achieve selective crystallization of l-phenylalanine anhydrate from aqueous solution. Water removal and crystallization were first studied separately, and models were used to define the limits of operation for the coupled system so that the target crystal form and production rate could be achieved. A narrow window of operation was obtained, and it was shown that practical implementation can be difficult due to operation near the limits of the window of operation. Possibilities for widening the window of operation are briefly discussed. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie8012659