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Conceptual evaluation of integrated process configurations for the recovery of i-phenylalanine product crystals during fermentation / Cuellar, Maria C. in Industrial & engineering chemistry research, Vol. 49 N° 2 (Janvier 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 2 (Janvier 2010) . - pp 682–689 Titre : Conceptual evaluation of integrated process configurations for the recovery of i-phenylalanine product crystals during fermentation Type de document : texte imprimé Auteurs : Cuellar, Maria C., Auteur ; Straathof, Adrie J. J., Auteur ; Van de Sandt, Emile J. A. X., Auteur Année de publication : 2010 Article en page(s) : pp 682–689 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Amino  acid  Anhydrate  crystals. Résumé : The production of the amino acid l-phenylalanine (Phe) by fermentation is in many cases limited by the tight regulation of the microbial pathway leading to Phe synthesis. One way of circumventing feedback repression is to remove the product from the vicinity of the micro-organism as soon as it is being formed. In the case of Phe, techniques like adsorption and extraction have been applied with this aim. In these processes, however, additional recovery steps are required in order to obtain the product as anhydrate crystals, which is its commercial form. In this work we evaluated conceptually the recovery of Phe anhydrate crystals during a fermentation process. The product recovery consisted of water removal by reverse osmosis, crystallization, and recycle of the mother liquor either to the fermenter, to the water removal unit or to both. By maintaining the Phe mass fraction in the fermenter at about 17 g kg−1 the fermentation productivity increased according to the calculations from 0.66 g kg−1 h−1, without product removal, to 1.07 g kg−1 h−1, with product removal, where about 70% of the produced Phe was directly recovered as anhydrate crystals. By means of a simplified economic model it was shown that the membranes required for cell retention and water removal have much more impact on the economic performance of the process than the consumption of raw materials, and therefore, the favored recycling option for the mother liquor is to the water removal unit DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie901007g [article] Conceptual evaluation of integrated process configurations for the recovery of i-phenylalanine product crystals during fermentation [texte imprimé] / Cuellar, Maria C., Auteur ; Straathof, Adrie J. J., Auteur ; Van de Sandt, Emile J. A. X., Auteur . - 2010 . - pp 682–689. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 2 (Janvier 2010) . - pp 682–689 Mots-clés : Amino  acid  Anhydrate  crystals. Résumé : The production of the amino acid l-phenylalanine (Phe) by fermentation is in many cases limited by the tight regulation of the microbial pathway leading to Phe synthesis. One way of circumventing feedback repression is to remove the product from the vicinity of the micro-organism as soon as it is being formed. In the case of Phe, techniques like adsorption and extraction have been applied with this aim. In these processes, however, additional recovery steps are required in order to obtain the product as anhydrate crystals, which is its commercial form. In this work we evaluated conceptually the recovery of Phe anhydrate crystals during a fermentation process. The product recovery consisted of water removal by reverse osmosis, crystallization, and recycle of the mother liquor either to the fermenter, to the water removal unit or to both. By maintaining the Phe mass fraction in the fermenter at about 17 g kg−1 the fermentation productivity increased according to the calculations from 0.66 g kg−1 h−1, without product removal, to 1.07 g kg−1 h−1, with product removal, where about 70% of the produced Phe was directly recovered as anhydrate crystals. By means of a simplified economic model it was shown that the membranes required for cell retention and water removal have much more impact on the economic performance of the process than the consumption of raw materials, and therefore, the favored recycling option for the mother liquor is to the water removal unit DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie901007g