| Titre : | Product design : A nanomized nutraceutical with enhanced bioactivity and bioavailability (2012) |
| Auteurs : | Yeuk Tin Lau, Auteur ; Na Chen, Auteur ; Kam Ming Ko, Auteur |
| Type de document : | Article : texte imprimé |
| Dans : | Industrial & engineering chemistry research (Vol. 51 N° 21, Mai 2012) |
| Article en page(s) : | pp. 7320-7326 |
| Note générale : | Industrial chemistry |
| Langues : | Anglais |
| Tags : | Bioavailability Product development |
| Résumé : | This study considered the design and process development of nanomized products in two product forms: nanoemulsion and nanodispersible solids. The effect of product formulation and processing conditions on product attributes such as particle size and appearance were studied using orange oil and Oil Red O as model compounds. The relationship between particle size and product quality in terms of bioactivity and bioavaflabflity was illustrated using schisandrin B, a strong antioxidant, as a model drug. The bioactivity as measured by in vivo glutathione regeneration capacity assay of schisandrin B with an average size of 45 nm was nearly double that of the original coarse schisandrin B; the corresponding bioavailability as measured by the plasma schisandrin B level in an animal study was 14.5-fold higher. |
| ISSN : | 0888-5885 |
| En ligne : | http://cat.inist.fr/?aModele=afficheN&cpsidt=25948472 |
