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Application of dynamic optimization techniques for poly(β-hydroxybutyrate) production in a fed-batch bioreactor / Lopez, Jimmy A. in Industrial & engineering chemistry research, Vol. 49 N° 4 (Fevrier 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 4 (Fevrier 2010) . - pp 1762–1769 Titre : Application of dynamic optimization techniques for poly(β-hydroxybutyrate) production in a fed-batch bioreactor Type de document : texte imprimé Auteurs : Lopez, Jimmy A., Auteur ; Verónica Bucalá, Auteur ; Villar, Marcelo A., Auteur Année de publication : 2010 Article en page(s) : pp 1762–1769 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Dynamic  optimization  Poly  β-hydroxybutyrate  Fed  batch  bioreactor. Résumé : Poly(β-hydroxybutyrate), PHB, is a microbial biopolymer produced by bacteria under unbalanced culture conditions. Such unbalanced conditions can be easily reached in a fed-batch bioreactor; therefore, it is important to know the system’s behavior as well as its constraints to induce unbalanced conditions that allow the optimization of feeding profiles and, consequently, PHB productivity. In this work, dynamic optimization has been applied to maximize PHB productivity in a fed-batch bioreactor. Optimal feeding profiles of carbon and nitrogen sources, as well as their respective concentrations, were obtained using gPROMS (generalized process modeling system). When there is reliable bioreaction kinetics available, dynamic optimization becomes a very valuable tool for predicting optimal operating conditions to maximize PHB productivity, with a considerable reduction in time and experimental costs. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9006547 [article] Application of dynamic optimization techniques for poly(β-hydroxybutyrate) production in a fed-batch bioreactor [texte imprimé] / Lopez, Jimmy A., Auteur ; Verónica Bucalá, Auteur ; Villar, Marcelo A., Auteur . - 2010 . - pp 1762–1769. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 4 (Fevrier 2010) . - pp 1762–1769 Mots-clés : Dynamic  optimization  Poly  β-hydroxybutyrate  Fed  batch  bioreactor. Résumé : Poly(β-hydroxybutyrate), PHB, is a microbial biopolymer produced by bacteria under unbalanced culture conditions. Such unbalanced conditions can be easily reached in a fed-batch bioreactor; therefore, it is important to know the system’s behavior as well as its constraints to induce unbalanced conditions that allow the optimization of feeding profiles and, consequently, PHB productivity. In this work, dynamic optimization has been applied to maximize PHB productivity in a fed-batch bioreactor. Optimal feeding profiles of carbon and nitrogen sources, as well as their respective concentrations, were obtained using gPROMS (generalized process modeling system). When there is reliable bioreaction kinetics available, dynamic optimization becomes a very valuable tool for predicting optimal operating conditions to maximize PHB productivity, with a considerable reduction in time and experimental costs. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9006547