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Auteur Asadishad, Bahareh
Documents disponibles écrits par cet auteur
Affiner la rechercheFolate-receptor-targeted delivery of doxorubicin using polyethylene glycol-functionalized gold nanoparticles / Asadishad, Bahareh in Industrial & engineering chemistry research, Vol. 49 N° 4 (Fevrier 2010)
[article]
in Industrial & engineering chemistry research > Vol. 49 N° 4 (Fevrier 2010) . - pp 1958–1963
Titre : Folate-receptor-targeted delivery of doxorubicin using polyethylene glycol-functionalized gold nanoparticles Type de document : texte imprimé Auteurs : Asadishad, Bahareh, Auteur ; Manouchehr Vossoughi, Auteur ; Alemzadeh, Iran, Auteur Année de publication : 2010 Article en page(s) : pp 1958–1963 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Doxorubicin Nanoparticles Polyethylene glycol. Résumé : Doxorubicin-loaded nanocarriers were produced employing folate-modified polyethylene glycol (PEG)-functionalized gold nanoparticles for targeted delivery to positive folate-receptor cancer cells. Doxorubicin and folate were, respectively, conjugated to activated-folate and activated-PEG. The conjugates formed doxorubicin nanocarrier with an average size of 12 nm in diameter. The drug release response of functionalized gold nanoparticles was characterized by an initial rapid drug release followed by a controlled release. The doxorubicin nanocarriers showed higher cytotoxic effect on folate-receptor-positive cells (KB cells) than folate-receptor-negative cells (A549 cells). Cell viability in healthy cells (HFF cells) in drug-loaded nanoparticles was higher compared to free doxorubicin. These nanocarriers might offer a cancer therapy with high targeting efficiency and lower side effects. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9011479 [article] Folate-receptor-targeted delivery of doxorubicin using polyethylene glycol-functionalized gold nanoparticles [texte imprimé] / Asadishad, Bahareh, Auteur ; Manouchehr Vossoughi, Auteur ; Alemzadeh, Iran, Auteur . - 2010 . - pp 1958–1963.
Chimie industrielle
Langues : Anglais (eng)
in Industrial & engineering chemistry research > Vol. 49 N° 4 (Fevrier 2010) . - pp 1958–1963
Mots-clés : Doxorubicin Nanoparticles Polyethylene glycol. Résumé : Doxorubicin-loaded nanocarriers were produced employing folate-modified polyethylene glycol (PEG)-functionalized gold nanoparticles for targeted delivery to positive folate-receptor cancer cells. Doxorubicin and folate were, respectively, conjugated to activated-folate and activated-PEG. The conjugates formed doxorubicin nanocarrier with an average size of 12 nm in diameter. The drug release response of functionalized gold nanoparticles was characterized by an initial rapid drug release followed by a controlled release. The doxorubicin nanocarriers showed higher cytotoxic effect on folate-receptor-positive cells (KB cells) than folate-receptor-negative cells (A549 cells). Cell viability in healthy cells (HFF cells) in drug-loaded nanoparticles was higher compared to free doxorubicin. These nanocarriers might offer a cancer therapy with high targeting efficiency and lower side effects. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9011479