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Folate-receptor-targeted delivery of doxorubicin using polyethylene glycol-functionalized gold nanoparticles / Asadishad, Bahareh in Industrial & engineering chemistry research, Vol. 49 N° 4 (Fevrier 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 4 (Fevrier 2010) . - pp 1958–1963 Titre : Folate-receptor-targeted delivery of doxorubicin using polyethylene glycol-functionalized gold nanoparticles Type de document : texte imprimé Auteurs : Asadishad, Bahareh, Auteur ; Manouchehr Vossoughi, Auteur ; Alemzadeh, Iran, Auteur Année de publication : 2010 Article en page(s) : pp 1958–1963 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Doxorubicin  Nanoparticles  Polyethylene  glycol. Résumé : Doxorubicin-loaded nanocarriers were produced employing folate-modified polyethylene glycol (PEG)-functionalized gold nanoparticles for targeted delivery to positive folate-receptor cancer cells. Doxorubicin and folate were, respectively, conjugated to activated-folate and activated-PEG. The conjugates formed doxorubicin nanocarrier with an average size of 12 nm in diameter. The drug release response of functionalized gold nanoparticles was characterized by an initial rapid drug release followed by a controlled release. The doxorubicin nanocarriers showed higher cytotoxic effect on folate-receptor-positive cells (KB cells) than folate-receptor-negative cells (A549 cells). Cell viability in healthy cells (HFF cells) in drug-loaded nanoparticles was higher compared to free doxorubicin. These nanocarriers might offer a cancer therapy with high targeting efficiency and lower side effects. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9011479 [article] Folate-receptor-targeted delivery of doxorubicin using polyethylene glycol-functionalized gold nanoparticles [texte imprimé] / Asadishad, Bahareh, Auteur ; Manouchehr Vossoughi, Auteur ; Alemzadeh, Iran, Auteur . - 2010 . - pp 1958–1963. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 4 (Fevrier 2010) . - pp 1958–1963 Mots-clés : Doxorubicin  Nanoparticles  Polyethylene  glycol. Résumé : Doxorubicin-loaded nanocarriers were produced employing folate-modified polyethylene glycol (PEG)-functionalized gold nanoparticles for targeted delivery to positive folate-receptor cancer cells. Doxorubicin and folate were, respectively, conjugated to activated-folate and activated-PEG. The conjugates formed doxorubicin nanocarrier with an average size of 12 nm in diameter. The drug release response of functionalized gold nanoparticles was characterized by an initial rapid drug release followed by a controlled release. The doxorubicin nanocarriers showed higher cytotoxic effect on folate-receptor-positive cells (KB cells) than folate-receptor-negative cells (A549 cells). Cell viability in healthy cells (HFF cells) in drug-loaded nanoparticles was higher compared to free doxorubicin. These nanocarriers might offer a cancer therapy with high targeting efficiency and lower side effects. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9011479

Turnip (brassica rapa) peroxidase / Sepideh Motamed in Industrial & engineering chemistry research, Vol. 48 N° 23 (Décembre 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N° 23 (Décembre 2009) . - pp. 10614–10618 Titre : Turnip (brassica rapa) peroxidase : purification and characterization Type de document : texte imprimé Auteurs : Sepideh Motamed, Auteur ; Farnoosh Ghaemmaghami, Auteur ; Alemzadeh, Iran, Auteur Année de publication : 2010 Article en page(s) : pp. 10614–10618 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Turnip--(Brassica  rapa)--Peroxidase--Purification--Characterization Résumé : Partial purification of plant peroxidase from turnip (Brassica rapa) was optimized. Aqueous two phase system and precipitation by ammonium sulfate (as two parallel purification methods) were used. Polyethylene glycol/ammonium sulfate/NaCl (25:7:3%, w/v) system followed by gel-filtration chromatography gave a purification factor of about 36 fold. On the other hand, ammonium sulfate precipitation (60−80% deg) followed by gel filtration gave only about 13 purification fold. Hence, the aqueous two-phase system was more efficient and useful method as a primary purification step since it was less laborious, less time-consuming, and led to more purification factor. The partially purified turnip enzyme was stable at a pH range 2.6−6.0 and had an optimum pH at 4.0. The enzyme was stable up to 55 °C with an optimum activity at 35 °C. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie801997e [article] Turnip (brassica rapa) peroxidase : purification and characterization [texte imprimé] / Sepideh Motamed, Auteur ; Farnoosh Ghaemmaghami, Auteur ; Alemzadeh, Iran, Auteur . - 2010 . - pp. 10614–10618. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 23 (Décembre 2009) . - pp. 10614–10618 Mots-clés : Turnip--(Brassica  rapa)--Peroxidase--Purification--Characterization Résumé : Partial purification of plant peroxidase from turnip (Brassica rapa) was optimized. Aqueous two phase system and precipitation by ammonium sulfate (as two parallel purification methods) were used. Polyethylene glycol/ammonium sulfate/NaCl (25:7:3%, w/v) system followed by gel-filtration chromatography gave a purification factor of about 36 fold. On the other hand, ammonium sulfate precipitation (60−80% deg) followed by gel filtration gave only about 13 purification fold. Hence, the aqueous two-phase system was more efficient and useful method as a primary purification step since it was less laborious, less time-consuming, and led to more purification factor. The partially purified turnip enzyme was stable at a pH range 2.6−6.0 and had an optimum pH at 4.0. The enzyme was stable up to 55 °C with an optimum activity at 35 °C. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie801997e