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Integrated model of IGF-I mediated biosynthesis in a deformed articular cartilage / Lihai Zhang in Journal of engineering mechanics, Vol. 135 N° 5 (Mai 2009) 

Public ISBD [article]  in Journal of engineering mechanics > Vol. 135 N° 5 (Mai 2009) . - pp. 439-449 Titre : Integrated model of IGF-I mediated biosynthesis in a deformed articular cartilage Type de document : texte imprimé Auteurs : Lihai Zhang, Auteur ; Bruce Stuart Gardiner, Auteur ; David Wamsley Smith, Auteur Article en page(s) : pp. 439-449 Note générale : Mécanique appliquée Langues : Anglais (eng) Mots-clés : Biological  properties  Mechanical  properties  Human  factors  Deformation  Integrated  systems. Résumé : Maintenance of articular cartilage's functional mechanical properties ultimately depends on the balance between the extracellular matrix component biosynthesis, degradation, and loss. A variety of factors are known to modulate the rate of cartilage matrix synthesis (e.g., growth factors and stress/strain environment). In the present study, we develop an integrated mathematical model that quantifies biological processes within cartilage tissue modulated by insulin-like growth factors (IGFs). Specifically, the model includes IGF transport through a deforming porous media, competitive binding to binding proteins and cell receptors, and matrix macromolecule biosynthesis—particularly glycosaminoglycans (GAGs). These newly synthesized matrix molecules are then able to modify the material properties of cartilage. The model is used to investigate the effect of synovial fluid IGF-I concentration on cartilage homeostasis. The results presented here suggest that GAG production can be rapidly “switched on” when the concentration of IGF-I reaches a certain threshold, while it is predicted that high receptor concentration leads to heterogeneous matrix production. As for the combined effect of IGF-I and mechanical loading on biosynthesis, the current model predicts that a loading regime with high strain magnitude (e.g., 10%) can achieve a synergistic effect on matrix protein production. Furthermore, dynamic loading is seen to promote spatial homogeneous GAG production. DEWEY : 620.1 ISSN : 0733-9399 En ligne : http://ascelibrary.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=JENMDT000 [...] [article] Integrated model of IGF-I mediated biosynthesis in a deformed articular cartilage [texte imprimé] / Lihai Zhang, Auteur ; Bruce Stuart Gardiner, Auteur ; David Wamsley Smith, Auteur . - pp. 439-449. Mécanique appliquée Langues : Anglais (eng) in Journal of engineering mechanics > Vol. 135 N° 5 (Mai 2009) . - pp. 439-449 Mots-clés : Biological  properties  Mechanical  properties  Human  factors  Deformation  Integrated  systems. Résumé : Maintenance of articular cartilage's functional mechanical properties ultimately depends on the balance between the extracellular matrix component biosynthesis, degradation, and loss. A variety of factors are known to modulate the rate of cartilage matrix synthesis (e.g., growth factors and stress/strain environment). In the present study, we develop an integrated mathematical model that quantifies biological processes within cartilage tissue modulated by insulin-like growth factors (IGFs). Specifically, the model includes IGF transport through a deforming porous media, competitive binding to binding proteins and cell receptors, and matrix macromolecule biosynthesis—particularly glycosaminoglycans (GAGs). These newly synthesized matrix molecules are then able to modify the material properties of cartilage. The model is used to investigate the effect of synovial fluid IGF-I concentration on cartilage homeostasis. The results presented here suggest that GAG production can be rapidly “switched on” when the concentration of IGF-I reaches a certain threshold, while it is predicted that high receptor concentration leads to heterogeneous matrix production. As for the combined effect of IGF-I and mechanical loading on biosynthesis, the current model predicts that a loading regime with high strain magnitude (e.g., 10%) can achieve a synergistic effect on matrix protein production. Furthermore, dynamic loading is seen to promote spatial homogeneous GAG production. DEWEY : 620.1 ISSN : 0733-9399 En ligne : http://ascelibrary.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=JENMDT000 [...]