| Titre : | Chemical composition, anti-angiogenic and cytotoxicity activities of the essential oils of cymbopogan citratus (lemon grass) against colorectal and breast carcinoma cell lines (2013) |
| Auteurs : | Suthagar Pillai Piaru, Auteur ; Shanmugapriya Perumal, Auteur ; Lee Wei Cai, Auteur |
| Type de document : | Article : texte imprimé |
| Dans : | The journal of essential oil research (Vol. 24 N° 5, Octobre 2012) |
| Article en page(s) : | pp. 453-459 |
| Note générale : | Génie Chimique |
| Langues : | Anglais |
| Tags : | Angiogenesis Cymbopogan citratus Cytotoxicity Essential oil composition |
| Résumé : | The essential oil of Cymbopogan citratus (lemon grass) was isolated by steam distillation method and subjected to cytotoxicity activity using two different cell lines, human colon carcinoma (HCT-116), breast carcinoma cell lines (MCF-7) and anti-angiogenic activity. The cytotoxicity activity study was determined using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2,4-tetrazolium bromide] assay and anti-angiogenic activity using rat aortic ring model. The chemical composition of the essential oil was determined by gas chromatography–mass spectrometry (GC–MS) and GC–flame ionization detection (FID). Forty-one compounds, representing 88.5% of the lemon grass oil was identified and the main components were neral (29.8%) and geranial (44.6%). The free radical scavenging activity of the essential oil showed an IC50 value of 156.1 μg/mL. The results showed that essential oil of lemon grass possessed potential cytotoxic effect on HCT-116 and with the IC50 value of 27.41 ± 4.3 μg/mL comparing to MCF-7 with IC50 value of 41.90 ± 1.2 μg/mL. Significant anti-angiogenic activity of the sample was observed with 99 ± 0.8% of inhibition at 100 μg/mL. |
| ISSN : | 1041-2905 |
| En ligne : | http://www.tandfonline.com/doi/full/10.1080/10412905.2012.703496 |
