| Titre : | Chemical composition and in vitro cytotoxic activity of xylopia aethiopica (Dun) A. rich. (Annonaceae) fruit essential oil from Togo (2008) |
| Auteurs : | Koffi Koba, Auteur ; Komla Sanda, Auteur ; Christine Raynaud, Auteur |
| Type de document : | Article : texte imprimé |
| Dans : | The journal of essential oil research (Vol. 20 n°4, Juillet/Août 2008) |
| Article en page(s) : | pp. 354-357 |
| Note générale : | Génie Chimique |
| Langues : | Anglais |
| Tags : | Xylopia aethiopica Essential oil β ; -pinene α ; -pinene HaCat cell line Cytotoxicity |
| Résumé : | Essential oil extracted (4.4% in yield) from air-dried fruits of Xylopia aethiopica harvested in Togo was investigated for percentage composition and in vitro cytotoxicity. The chemical composition of the essential oil was examined by GC and GC/MS. Thirty-five compounds were identified representing 89.9% of total oil. The major constituents were β-pinene (23.6%), α-pinene (11%), sabinene (9.8%), germacrene D (8.3%) and 1,8 cineole (8.2%). The cytotoxicity of the volatile oil was evaluated in vitro on the human epidermal cell line HaCaT. The tested sample did not show any cytotoxicity (IC50 >3000 μg.ml-1) effect at concentrations around 3000 μg.ml-1. Further testing in bioassay would probably help in validating some of medicinal uses of X. aethiopica in topical drugs and/or in cosmetics as natural products. |
| ISSN : | 1041-2905 |
| En ligne : | http://www.tandfonline.com/doi/abs/10.1080/10412905.2008.9700029 |
