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Optimal drug-aerosol delivery to predetermined ung sites / Clement Kleinstreuer in Journal of heat transfer, Vol. 133 N° 1(N° Spécial) (Janvier 2011) 

Public ISBD [article]  in Journal of heat transfer > Vol. 133 N° 1(N° Spécial) (Janvier 2011) . - pp. [011002/1-12] Titre : Optimal drug-aerosol delivery to predetermined ung sites Type de document : texte imprimé Auteurs : Clement Kleinstreuer, Auteur ; Zhe Zhang, Auteur Année de publication : 2011 Article en page(s) : pp. [011002/1-12] Note générale : Physique Langues : Anglais (eng) Mots-clés : Subject-specific  lung  airways  Air-particle  flow  Computer  simulation  results  Inhaler  devices  Optimal  drug-aerosol  targeting  Smart  inhaler  system Index. décimale : 536 Chaleur. Thermodynamique Résumé : This review summarizes computer simulation methodologies of air-particle flow, results of drug-aerosol transport/deposition in models of the human respiratory system, as well as aspects of drug-aerosol targeting and associated inhalation devices. After a brief introduction to drug delivery systems in general, the required modeling and simulation steps for optimal drug-aerosol delivery in the lung are outlined. Starting with medical imaging and file conversion of patient-specific lung-airway morphologies, the air-particle transport phenomena are numerically solved for a representative inhalation flow rate of Qtotal=30 l/min. Focusing on microspheres and droplets, the complex airflow and particle dynamics, as well as the droplet heat and mass transfer are illustrated. With this foundation as the background, an overview of present inhaler devices is presented, followed by a discussion of the methodology and features of a new smart inhaler system (SIS). With the SIS, inhaled drug-aerosols can be directly delivered to any predetermined target area in the human lung. DEWEY : 536 ISSN : 0022-1481 En ligne : http://asmedl.aip.org/vsearch/servlet/VerityServlet?KEY=JHTRAO&ONLINE=YES&smode= [...] [article] Optimal drug-aerosol delivery to predetermined ung sites [texte imprimé] / Clement Kleinstreuer, Auteur ; Zhe Zhang, Auteur . - 2011 . - pp. [011002/1-12]. Physique Langues : Anglais (eng) in Journal of heat transfer > Vol. 133 N° 1(N° Spécial) (Janvier 2011) . - pp. [011002/1-12] Mots-clés : Subject-specific  lung  airways  Air-particle  flow  Computer  simulation  results  Inhaler  devices  Optimal  drug-aerosol  targeting  Smart  inhaler  system Index. décimale : 536 Chaleur. Thermodynamique Résumé : This review summarizes computer simulation methodologies of air-particle flow, results of drug-aerosol transport/deposition in models of the human respiratory system, as well as aspects of drug-aerosol targeting and associated inhalation devices. After a brief introduction to drug delivery systems in general, the required modeling and simulation steps for optimal drug-aerosol delivery in the lung are outlined. Starting with medical imaging and file conversion of patient-specific lung-airway morphologies, the air-particle transport phenomena are numerically solved for a representative inhalation flow rate of Qtotal=30 l/min. Focusing on microspheres and droplets, the complex airflow and particle dynamics, as well as the droplet heat and mass transfer are illustrated. With this foundation as the background, an overview of present inhaler devices is presented, followed by a discussion of the methodology and features of a new smart inhaler system (SIS). With the SIS, inhaled drug-aerosols can be directly delivered to any predetermined target area in the human lung. DEWEY : 536 ISSN : 0022-1481 En ligne : http://asmedl.aip.org/vsearch/servlet/VerityServlet?KEY=JHTRAO&ONLINE=YES&smode= [...]