| Titre : | Novel pH - sensitive hydrogels prepared from the blends of poly(vinyl alcohol) with acrylic acid - graft - guar gum matrixes for isoniazid delivery (2010) |
| Auteurs : | Anita G. Sullad, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur |
| Type de document : | Article : texte imprimé |
| Dans : | Industrial & engineering chemistry research (Vol. 49 N° 16, Août 2010) |
| Article en page(s) : | pp. 7323–7329 |
| Note générale : | Industrial chemistry |
| Langues : | Anglais |
| Tags : | Hydrogels |
| Résumé : | A novel type of pH-sensitive hydrogel blend of poly(vinyl alcohol) with acrylic acid-graft-guar gum has been prepared. Microspheres with a size of 10 μm were produced by the water-in-oil (w/o) emulsification method for investigating the controlled release of an antituberculosis drug, isoniazid. These novel carriers were analyzed for surface morphology, size, effect of pH, swelling, drug loading, and in vitro release of isoniazid in pH 1.2 and 7.4 media. The kinetics of drug release was analyzed using empirical equations. Release times of the drug were increased to 8 h from its nascent plasma half-life of 0.5−1.6 h. |
| ISSN : | 0888-5885 |
| En ligne : | http://pubs.acs.org/doi/abs/10.1021/ie100389v |
