Documents disponibles écrits par cet auteur

Evaluating the machinability of inconel 718 using polar diagrams / Pajazit Avdovic in Transactions of the ASME . Journal of engineering for gas turbines and power, Vol. 133 N° 7 (Juillet 2011) 

Public ISBD [article]  in Transactions of the ASME . Journal of engineering for gas turbines and power > Vol. 133 N° 7 (Juillet 2011) . - 07 p. Titre : Evaluating the machinability of inconel 718 using polar diagrams Type de document : texte imprimé Auteurs : Pajazit Avdovic, Auteur ; Linhong Xu, Auteur ; Mats Andersson, Auteur Année de publication : 2011 Article en page(s) : 07 p. Note générale : Turbines à gaz Langues : Anglais (eng) Mots-clés : Polar  diagram  Machinability  Inconel  718 Index. décimale : 620.1 Essais des matériaux. Défauts des matériaux. Protection des matériaux Résumé : The use of a polar diagram method for describing and evaluating the machinability of Inconel 718 was explored. Five key parameters of the work material, representing the mechanical and physical properties, which have the strongest influence on its machinability, were employed in the diagrams. These five parameters were integrated into a single polar diagram, used to describe the machinability of Inconel 718. Variations in the machinability of Inconel 718 products or components of a given type produced in different batches were analyzed. Industrial experiments were conducted to test the relationship between the polar diagram of the work material, its carbon content, and the tool wear of the ceramic cutting tools used in machining it. Work materials of Inconel 718 in which the polar diagrams of machinability were similar in size and shape exhibited very similar behavior during the cutting process. The polar diagram method employed appeared to be useful for selecting suitable cutting data for the machining of new materials. DEWEY : 620.1 ISSN : 0742-4795 En ligne : http://asmedl.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=JETPEZ00013300 [...] [article] Evaluating the machinability of inconel 718 using polar diagrams [texte imprimé] / Pajazit Avdovic, Auteur ; Linhong Xu, Auteur ; Mats Andersson, Auteur . - 2011 . - 07 p. Turbines à gaz Langues : Anglais (eng) in Transactions of the ASME . Journal of engineering for gas turbines and power > Vol. 133 N° 7 (Juillet 2011) . - 07 p. Mots-clés : Polar  diagram  Machinability  Inconel  718 Index. décimale : 620.1 Essais des matériaux. Défauts des matériaux. Protection des matériaux Résumé : The use of a polar diagram method for describing and evaluating the machinability of Inconel 718 was explored. Five key parameters of the work material, representing the mechanical and physical properties, which have the strongest influence on its machinability, were employed in the diagrams. These five parameters were integrated into a single polar diagram, used to describe the machinability of Inconel 718. Variations in the machinability of Inconel 718 products or components of a given type produced in different batches were analyzed. Industrial experiments were conducted to test the relationship between the polar diagram of the work material, its carbon content, and the tool wear of the ceramic cutting tools used in machining it. Work materials of Inconel 718 in which the polar diagrams of machinability were similar in size and shape exhibited very similar behavior during the cutting process. The polar diagram method employed appeared to be useful for selecting suitable cutting data for the machining of new materials. DEWEY : 620.1 ISSN : 0742-4795 En ligne : http://asmedl.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=JETPEZ00013300 [...]

Formulation of poorly water - soluble compound loaded solid lipid nanoparticles in a microchannel system fabricated by mechanical microcutting method / Linhong Xu in Industrial & engineering chemistry research, Vol. 51 N° 35 (Septembre 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 35 (Septembre 2012) . - pp. 11373–11380 Titre : Formulation of poorly water - soluble compound loaded solid lipid nanoparticles in a microchannel system fabricated by mechanical microcutting method : Puerarin as a model drug Type de document : texte imprimé Auteurs : Linhong Xu, Auteur ; Xu Tan, Auteur ; Junxian Yun, Auteur Année de publication : 2012 Article en page(s) : pp. 11373–11380 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Nanoparticles  Microchannel  Microcutting  method Résumé : Delivery of poorly water-soluble compounds by use of nanosized lipid carriers has attracted much attention in pharmaceutical and therapeutic areas in recent years. However, it is difficult to formulate poorly water-soluble compound loaded lipid nanoparticles with narrow size distributions and proper drug load properties. In the present work, we introduce a precise mechanical manufacture method, the microcutting approach, to fabricate a microchannel system on a stainless steel slab, which was then assembled and employed to prepare poorly water-soluble drug loaded solid lipid nanoparticles (SLNs) by liquid flow-focusing and gas displacing techniques. A poorly water-soluble drug, puerarin, was used as the model drug, and the production of puerarin-loaded SLNs was achieved under various conditions. Particle size distribution of the obtained drug-loaded SLNs was measured by dynamic light scattering (DLS), and the particle morphology was observed by transmission electron microscopy (TEM). The state of the drug-loaded SLNs was analyzed by differential scanning calorimetry (DSC), and the drug load was determined by high-performance liquid chromatography (HPLC). The results showed that microchannels fabricated by the present mechanical microcutting method were excellent in surface quality and precise in channel sizes and shapes, which are easily scaled-up. The puerarin-loaded SLNs prepared by the present microchannel system have a narrow size distribution and the mean particle size varied with the velocities of fluids and the lipid concentration. The drug load capacity of puerarin was influenced by preparation parameters, like the flow velocities of liquids and the concentrations of lipid and puerarin. Therefore, by employing suitable preparation parameters, one can produce poorly water-soluble drug loaded SLNs with expected sizes and drug load capacities by use of microchannels fabricated by the microcutting method, which could be an effective and alternative approach for scale-up production of those new nanosized delivery systems containing poorly water-soluble drugs for potential pharmaceutical and therapeutic applications. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie300592u [article] Formulation of poorly water - soluble compound loaded solid lipid nanoparticles in a microchannel system fabricated by mechanical microcutting method : Puerarin as a model drug [texte imprimé] / Linhong Xu, Auteur ; Xu Tan, Auteur ; Junxian Yun, Auteur . - 2012 . - pp. 11373–11380. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 35 (Septembre 2012) . - pp. 11373–11380 Mots-clés : Nanoparticles  Microchannel  Microcutting  method Résumé : Delivery of poorly water-soluble compounds by use of nanosized lipid carriers has attracted much attention in pharmaceutical and therapeutic areas in recent years. However, it is difficult to formulate poorly water-soluble compound loaded lipid nanoparticles with narrow size distributions and proper drug load properties. In the present work, we introduce a precise mechanical manufacture method, the microcutting approach, to fabricate a microchannel system on a stainless steel slab, which was then assembled and employed to prepare poorly water-soluble drug loaded solid lipid nanoparticles (SLNs) by liquid flow-focusing and gas displacing techniques. A poorly water-soluble drug, puerarin, was used as the model drug, and the production of puerarin-loaded SLNs was achieved under various conditions. Particle size distribution of the obtained drug-loaded SLNs was measured by dynamic light scattering (DLS), and the particle morphology was observed by transmission electron microscopy (TEM). The state of the drug-loaded SLNs was analyzed by differential scanning calorimetry (DSC), and the drug load was determined by high-performance liquid chromatography (HPLC). The results showed that microchannels fabricated by the present mechanical microcutting method were excellent in surface quality and precise in channel sizes and shapes, which are easily scaled-up. The puerarin-loaded SLNs prepared by the present microchannel system have a narrow size distribution and the mean particle size varied with the velocities of fluids and the lipid concentration. The drug load capacity of puerarin was influenced by preparation parameters, like the flow velocities of liquids and the concentrations of lipid and puerarin. Therefore, by employing suitable preparation parameters, one can produce poorly water-soluble drug loaded SLNs with expected sizes and drug load capacities by use of microchannels fabricated by the microcutting method, which could be an effective and alternative approach for scale-up production of those new nanosized delivery systems containing poorly water-soluble drugs for potential pharmaceutical and therapeutic applications. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie300592u