| Titre : | Alternative method with amperometric detection for ranitidine determination (2010) |
| Auteurs : | Valeria Pfaffen, Auteur ; Patricia Inés Ortiz, Auteur |
| Type de document : | Article : texte imprimé |
| Dans : | Industrial & engineering chemistry research (Vol. 49 N° 9, Mai 2010) |
| Article en page(s) : | pp. 4026-4030 |
| Note générale : | Industrial chemistry |
| Langues : | Anglais |
| Tags : | Amperometric Detection Ranitidine |
| Résumé : | An alternative, simple, and reliable FIA amperometric method for ranitidine quantification was developed. A working glassy carbon electrode and a Ag|AgCl|NaCl (3 M) reference electrode were used. The determination is based on the electrochemical oxidation of ranitidine at 1.2 V in phosphate buffer solution (pH 7.2). The determination of ranitidine in the range of 1 × 10−6 to 2 × 10−5 M was possible with a sampling frequency of 120 h−1. The method was validated and satisfactorily applied to the determination of ranitidine in pharmaceutical formulations with a low limit of detection (6 × 10−7 M) and a quantitative recovery with no interferences from excipients. The results compare favorably with those obtained by the liquid chromatographic method of the U.S. Pharmacopoeia. |
| ISSN : | 0888-5885 |
| En ligne : | http://pubs.acs.org/doi/abs/10.1021/ie901895a |
