Documents disponibles écrits par cet auteur

Dynamic parameters estimation method: advanced manometric temperature measurement approach for freeze-drying monitoring of pharmaceutical solutions / Salvatore A. Velardi in Industrial & engineering chemistry research, Vol. 47 n°21 (Novembre 2008) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 47 n°21 (Novembre 2008) . - p. 8445–8457 Titre : Dynamic parameters estimation method: advanced manometric temperature measurement approach for freeze-drying monitoring of pharmaceutical solutions Type de document : texte imprimé Auteurs : Salvatore A. Velardi, Auteur ; Valeria Rasetto, Auteur ; Antonello A. Barresi, Auteur Année de publication : 2008 Article en page(s) : p. 8445–8457 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : The  dynamic  parameters  technique  for  the  freeze-drying Résumé : The aim of this paper is to describe and validate the dynamic parameters estimation (DPE) method, a noninvasive in-line monitoring technique for the freeze-drying process of pharmaceuticals that only requires pressure measurement; simulations and experimental data of pharmaceutical solutions in vials are used to this purpose. This method has to be considered as an improvement of analogous techniques, such as the manometric temperature measurement (MTM) method, which are also based on the pressure rise analysis concept. The proposed approach is able to estimate not only the temperature profile inside the frozen product at any time during the pressure rise test, but also the position of the moving interface of sublimation, the external heat transfer coefficient, and the effective diffusivity coefficient in the dried product, which are necessary for a predictive model-based control algorithm. Fairly good estimations of the product temperature and of the transport parameters, as well as of the position of the interface of sublimation, which is directly related to the state of progression of the primary drying phase, are obtained along almost all the primary drying phase. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie7017433 [article] Dynamic parameters estimation method: advanced manometric temperature measurement approach for freeze-drying monitoring of pharmaceutical solutions [texte imprimé] / Salvatore A. Velardi, Auteur ; Valeria Rasetto, Auteur ; Antonello A. Barresi, Auteur . - 2008 . - p. 8445–8457. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 47 n°21 (Novembre 2008) . - p. 8445–8457 Mots-clés : The  dynamic  parameters  technique  for  the  freeze-drying Résumé : The aim of this paper is to describe and validate the dynamic parameters estimation (DPE) method, a noninvasive in-line monitoring technique for the freeze-drying process of pharmaceuticals that only requires pressure measurement; simulations and experimental data of pharmaceutical solutions in vials are used to this purpose. This method has to be considered as an improvement of analogous techniques, such as the manometric temperature measurement (MTM) method, which are also based on the pressure rise analysis concept. The proposed approach is able to estimate not only the temperature profile inside the frozen product at any time during the pressure rise test, but also the position of the moving interface of sublimation, the external heat transfer coefficient, and the effective diffusivity coefficient in the dried product, which are necessary for a predictive model-based control algorithm. Fairly good estimations of the product temperature and of the transport parameters, as well as of the position of the interface of sublimation, which is directly related to the state of progression of the primary drying phase, are obtained along almost all the primary drying phase. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie7017433

Effect of mixing and other operating parameters in sol-gel processes / Daniele L. Marchisio in Industrial & engineering chemistry research, Vol. 47 N°19 (Octobre 2008) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 47 N°19 (Octobre 2008) . - p. 7202–7210 Titre : Effect of mixing and other operating parameters in sol-gel processes Type de document : texte imprimé Auteurs : Daniele L. Marchisio, Auteur ; Federica Omegna, Auteur ; Antonello A. Barresi, Auteur Année de publication : 2008 Article en page(s) : p. 7202–7210 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Sol-gel  process  Titanium  dioxide  synthesis  Thermal  treatments Résumé : In this work the effect of mixing on a sol−gel process is quantitatively investigated. Titanium dioxide synthesis from titanium tetra-isopropoxide is used as a test reaction. Solutions of titanium alkoxide in isopropyl alcohol and water in isopropyl alcohol are mixed in a special mixing device (i.e., vortex reactor) at different mixing rates, and the effect of mixing is quantified and compared with the effect of the other relevant operating parameters, namely the water to alkoxide, acid to alkoxide ratios, and alkoxide initial concentration. Dynamic light scattering, specific surface area measurement through nitrogen adsorption, X-ray diffraction, and field emission scanning electron microscopy are employed to determine particle size distribution, morphology, and crystallite size of the different particulate products (i.e., sols, gels, powders) obtained before and after thermal treatments under different synthesis conditions. A factorial design is used to plan the experimental campaign and results show that the role of mixing cannot be neglected. Moreover results show that mixing can be actively used to control the final product characteristics and must be taken into account when a process is transferred from the laboratory to the industrial scale. Eventually a scale-up criterion based on our previous work will be discussed. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie800217b [article] Effect of mixing and other operating parameters in sol-gel processes [texte imprimé] / Daniele L. Marchisio, Auteur ; Federica Omegna, Auteur ; Antonello A. Barresi, Auteur . - 2008 . - p. 7202–7210. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 47 N°19 (Octobre 2008) . - p. 7202–7210 Mots-clés : Sol-gel  process  Titanium  dioxide  synthesis  Thermal  treatments Résumé : In this work the effect of mixing on a sol−gel process is quantitatively investigated. Titanium dioxide synthesis from titanium tetra-isopropoxide is used as a test reaction. Solutions of titanium alkoxide in isopropyl alcohol and water in isopropyl alcohol are mixed in a special mixing device (i.e., vortex reactor) at different mixing rates, and the effect of mixing is quantified and compared with the effect of the other relevant operating parameters, namely the water to alkoxide, acid to alkoxide ratios, and alkoxide initial concentration. Dynamic light scattering, specific surface area measurement through nitrogen adsorption, X-ray diffraction, and field emission scanning electron microscopy are employed to determine particle size distribution, morphology, and crystallite size of the different particulate products (i.e., sols, gels, powders) obtained before and after thermal treatments under different synthesis conditions. A factorial design is used to plan the experimental campaign and results show that the role of mixing cannot be neglected. Moreover results show that mixing can be actively used to control the final product characteristics and must be taken into account when a process is transferred from the laboratory to the industrial scale. Eventually a scale-up criterion based on our previous work will be discussed. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie800217b

Freeze-drying cycle optimization using model predictive control techniques / Roberto Pisano in Industrial & engineering chemistry research, Vol. 50 N° 12 (Juin 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 12 (Juin 2011) . - pp. 7363-7379 Titre : Freeze-drying cycle optimization using model predictive control techniques Type de document : texte imprimé Auteurs : Roberto Pisano, Auteur ; Davide Fissore, Auteur ; Antonello A. Barresi, Auteur Année de publication : 2011 Article en page(s) : pp. 7363-7379 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Predictive  control  Modeling  Optimization  Freeze  drying Résumé : The problem of process control in the field of pharmaceutical freeze drying is discussed, and a model predictive control (MPC) system is proposed to control, and optimize, in-line the primary drying step, beside preserving product quality. The controller can provide the optimal recipe for a given product, taking into account process constraints and modeling errors. Two control algorithms are proposed: the former manipulates both the chamber pressure and the temperature of the technical fluid, while the latter manipulates only the temperature of the fluid. The optimal formulation of the algorithms and the tuning of controller parameters are discussed by means of mathematical simulations. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24239052 [article] Freeze-drying cycle optimization using model predictive control techniques [texte imprimé] / Roberto Pisano, Auteur ; Davide Fissore, Auteur ; Antonello A. Barresi, Auteur . - 2011 . - pp. 7363-7379. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 12 (Juin 2011) . - pp. 7363-7379 Mots-clés : Predictive  control  Modeling  Optimization  Freeze  drying Résumé : The problem of process control in the field of pharmaceutical freeze drying is discussed, and a model predictive control (MPC) system is proposed to control, and optimize, in-line the primary drying step, beside preserving product quality. The controller can provide the optimal recipe for a given product, taking into account process constraints and modeling errors. Two control algorithms are proposed: the former manipulates both the chamber pressure and the temperature of the technical fluid, while the latter manipulates only the temperature of the fluid. The optimal formulation of the algorithms and the tuning of controller parameters are discussed by means of mathematical simulations. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24239052

Model - based framework for the analysis of failure consequences in a freeze - drying process / Davide Fissore in Industrial & engineering chemistry research, Vol. 51 N° 38 (Septembre 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 38 (Septembre 2012) . - pp. 12386-12397 Titre : Model - based framework for the analysis of failure consequences in a freeze - drying process Type de document : texte imprimé Auteurs : Davide Fissore, Auteur ; Roberto Pisano, Auteur ; Antonello A. Barresi, Auteur Année de publication : 2012 Article en page(s) : pp. 12386-12397 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Freeze  drying  Modeling Résumé : This paper shows how mathematical modeling can be used to assess the effect of process failures on product quality during the freeze-drying of pharmaceutical and biotech products. In particular, the model is used to calculate the product temperature response after an unexpected variation in the temperature of the heat transfer fluid and/or in the chamber pressure. Here a monodimensional model is used as it requires a limited number of parameters, which are the heat transfer coefficient and the product resistance to vapor flow. In this paper, the problem of determination of model parameters is addressed, with emphasis on the nonuniformity of the batch and on the uncertainty of the method of measurement used. The heat transfer coefficient was determined by gravimetric method, while the product resistance to vapor flow was measured by a weighing device placed directly in the chamber. Results obtained by the above devices agreed with the values estimated by the pressure rise test technique. This paper also shows how mathematical modeling can be used to calculate the probability that product temperature is maintained below its limit value, as well as to estimate the new duration for the primary drying. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26399690 [article] Model - based framework for the analysis of failure consequences in a freeze - drying process [texte imprimé] / Davide Fissore, Auteur ; Roberto Pisano, Auteur ; Antonello A. Barresi, Auteur . - 2012 . - pp. 12386-12397. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 38 (Septembre 2012) . - pp. 12386-12397 Mots-clés : Freeze  drying  Modeling Résumé : This paper shows how mathematical modeling can be used to assess the effect of process failures on product quality during the freeze-drying of pharmaceutical and biotech products. In particular, the model is used to calculate the product temperature response after an unexpected variation in the temperature of the heat transfer fluid and/or in the chamber pressure. Here a monodimensional model is used as it requires a limited number of parameters, which are the heat transfer coefficient and the product resistance to vapor flow. In this paper, the problem of determination of model parameters is addressed, with emphasis on the nonuniformity of the batch and on the uncertainty of the method of measurement used. The heat transfer coefficient was determined by gravimetric method, while the product resistance to vapor flow was measured by a weighing device placed directly in the chamber. Results obtained by the above devices agreed with the values estimated by the pressure rise test technique. This paper also shows how mathematical modeling can be used to calculate the probability that product temperature is maintained below its limit value, as well as to estimate the new duration for the primary drying. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26399690