Documents disponibles écrits par cet auteur

Comparison of two separation technologies applied in the manufacture of botanical injections / Xingchu Gong in Industrial & engineering chemistry research, Vol. 50 N° 12 (Juin 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 12 (Juin 2011) . - pp. 7542-7548 Titre : Comparison of two separation technologies applied in the manufacture of botanical injections : second ethanol precipitation and solvent extraction Type de document : texte imprimé Auteurs : Xingchu Gong, Auteur ; Shanshan Wang, Auteur ; Haibin Qu, Auteur Année de publication : 2011 Article en page(s) : pp. 7542-7548 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Solvent  extraction Résumé : A botanical injection is a special drug preparation with extremely high safety requirements. Therefore, many separation technologies, such as ethanol precipitation and liquid―liquid extraction, are applied in the manufacturing process of botanical injections to purify efficacy compounds and remove impurities. In this work, second ethanol precipitation and 1-butanol extraction were compared in the purification of the concentrated supernatant of danshen (the dried root of Salvia miltiorrhiza). These two separation technologies showed satisfactory recovery of phenolic compounds and similar removal of total protein. Liquid-liquid extraction removed more saccharides than second ethanol precipitation. Accordingly, the purity of phenolic compounds increased remarkably after liquid—liquid extraction. According to the characteristics of the two separation technologies, the combination technology of "ethanol precipitation + liquid―liquid extraction" showed more advantages in drug safety and product quality control than the combination technology of "ethanol precipitation + second ethanol precipitation". DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24239071 [article] Comparison of two separation technologies applied in the manufacture of botanical injections : second ethanol precipitation and solvent extraction [texte imprimé] / Xingchu Gong, Auteur ; Shanshan Wang, Auteur ; Haibin Qu, Auteur . - 2011 . - pp. 7542-7548. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 12 (Juin 2011) . - pp. 7542-7548 Mots-clés : Solvent  extraction Résumé : A botanical injection is a special drug preparation with extremely high safety requirements. Therefore, many separation technologies, such as ethanol precipitation and liquid―liquid extraction, are applied in the manufacturing process of botanical injections to purify efficacy compounds and remove impurities. In this work, second ethanol precipitation and 1-butanol extraction were compared in the purification of the concentrated supernatant of danshen (the dried root of Salvia miltiorrhiza). These two separation technologies showed satisfactory recovery of phenolic compounds and similar removal of total protein. Liquid-liquid extraction removed more saccharides than second ethanol precipitation. Accordingly, the purity of phenolic compounds increased remarkably after liquid—liquid extraction. According to the characteristics of the two separation technologies, the combination technology of "ethanol precipitation + liquid―liquid extraction" showed more advantages in drug safety and product quality control than the combination technology of "ethanol precipitation + second ethanol precipitation". DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24239071

Preparation of uniform microcapsules containing 1-octanol for caprolactam extraction / Xingchu Gong in Industrial & engineering chemistry research, Vol. 48 N° 9 (Mai 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N° 9 (Mai 2009) . - pp. 4507–4513 Titre : Preparation of uniform microcapsules containing 1-octanol for caprolactam extraction Type de document : texte imprimé Auteurs : Xingchu Gong, Auteur ; Yangcheng Lu, Auteur ; Zhixi Qian, Auteur Année de publication : 2009 Article en page(s) : pp. 4507–4513 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Polysulfone  microcapsules  1-octanol  Coaxial  microchannel  N2  gas  Caprolactam  extraction Résumé : This paper presents a novel method to prepare uniform polysulfone (PSF) microcapsules that contain 1-octanol to prevent emulsification when pure 1-octanol is used as the solvent. In this method, a coaxial microchannel device was designed and N2 gas was introduced to control the drop size of polymer solution. Uniform microcapsules were successfully prepared and the diameter decreased linearly with the increase of the N2 flow rate. The pore volume and 1-octanol loading ratio could be controlled by changing the PSF content in polymer solution. The maximum loading of 1-octanol was 6.98 g/g PSF when the pore volume was 8.28 mL/g. The extraction capacity of the prepared microcapsules was determined, and it was found that the uptake of caprolactam was mainly influenced by the 1-octanol mass fraction in microcapsules, because the PSF shell did not adsorb much caprolactam. A maximum uptake of 58.8 mg caprolactam/g microcapsule was reached. The extraction kinetics of the prepared microcapsules also was determined. It was determined that the mass-transfer rate was determined by inner diffusion. The apparent diffusion coefficient of 9.1 × 10−11 m2/s was obtained. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900046u [article] Preparation of uniform microcapsules containing 1-octanol for caprolactam extraction [texte imprimé] / Xingchu Gong, Auteur ; Yangcheng Lu, Auteur ; Zhixi Qian, Auteur . - 2009 . - pp. 4507–4513. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 9 (Mai 2009) . - pp. 4507–4513 Mots-clés : Polysulfone  microcapsules  1-octanol  Coaxial  microchannel  N2  gas  Caprolactam  extraction Résumé : This paper presents a novel method to prepare uniform polysulfone (PSF) microcapsules that contain 1-octanol to prevent emulsification when pure 1-octanol is used as the solvent. In this method, a coaxial microchannel device was designed and N2 gas was introduced to control the drop size of polymer solution. Uniform microcapsules were successfully prepared and the diameter decreased linearly with the increase of the N2 flow rate. The pore volume and 1-octanol loading ratio could be controlled by changing the PSF content in polymer solution. The maximum loading of 1-octanol was 6.98 g/g PSF when the pore volume was 8.28 mL/g. The extraction capacity of the prepared microcapsules was determined, and it was found that the uptake of caprolactam was mainly influenced by the 1-octanol mass fraction in microcapsules, because the PSF shell did not adsorb much caprolactam. A maximum uptake of 58.8 mg caprolactam/g microcapsule was reached. The extraction kinetics of the prepared microcapsules also was determined. It was determined that the mass-transfer rate was determined by inner diffusion. The apparent diffusion coefficient of 9.1 × 10−11 m2/s was obtained. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900046u