Documents disponibles écrits par cet auteur

Comparison of two separation technologies applied in the manufacture of botanical injections / Xingchu Gong in Industrial & engineering chemistry research, Vol. 50 N° 12 (Juin 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 12 (Juin 2011) . - pp. 7542-7548 Titre : Comparison of two separation technologies applied in the manufacture of botanical injections : second ethanol precipitation and solvent extraction Type de document : texte imprimé Auteurs : Xingchu Gong, Auteur ; Shanshan Wang, Auteur ; Haibin Qu, Auteur Année de publication : 2011 Article en page(s) : pp. 7542-7548 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Solvent  extraction Résumé : A botanical injection is a special drug preparation with extremely high safety requirements. Therefore, many separation technologies, such as ethanol precipitation and liquid―liquid extraction, are applied in the manufacturing process of botanical injections to purify efficacy compounds and remove impurities. In this work, second ethanol precipitation and 1-butanol extraction were compared in the purification of the concentrated supernatant of danshen (the dried root of Salvia miltiorrhiza). These two separation technologies showed satisfactory recovery of phenolic compounds and similar removal of total protein. Liquid-liquid extraction removed more saccharides than second ethanol precipitation. Accordingly, the purity of phenolic compounds increased remarkably after liquid—liquid extraction. According to the characteristics of the two separation technologies, the combination technology of "ethanol precipitation + liquid―liquid extraction" showed more advantages in drug safety and product quality control than the combination technology of "ethanol precipitation + second ethanol precipitation". DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24239071 [article] Comparison of two separation technologies applied in the manufacture of botanical injections : second ethanol precipitation and solvent extraction [texte imprimé] / Xingchu Gong, Auteur ; Shanshan Wang, Auteur ; Haibin Qu, Auteur . - 2011 . - pp. 7542-7548. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 12 (Juin 2011) . - pp. 7542-7548 Mots-clés : Solvent  extraction Résumé : A botanical injection is a special drug preparation with extremely high safety requirements. Therefore, many separation technologies, such as ethanol precipitation and liquid―liquid extraction, are applied in the manufacturing process of botanical injections to purify efficacy compounds and remove impurities. In this work, second ethanol precipitation and 1-butanol extraction were compared in the purification of the concentrated supernatant of danshen (the dried root of Salvia miltiorrhiza). These two separation technologies showed satisfactory recovery of phenolic compounds and similar removal of total protein. Liquid-liquid extraction removed more saccharides than second ethanol precipitation. Accordingly, the purity of phenolic compounds increased remarkably after liquid—liquid extraction. According to the characteristics of the two separation technologies, the combination technology of "ethanol precipitation + liquid―liquid extraction" showed more advantages in drug safety and product quality control than the combination technology of "ethanol precipitation + second ethanol precipitation". DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24239071