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New approach to pesticide delivery using nanosuspensions / Chih-Ping Chin in Industrial & engineering chemistry research, Vol. 50 N° 12 (Juin 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 12 (Juin 2011) . - pp. 7637-7643 Titre : New approach to pesticide delivery using nanosuspensions : research and applications Type de document : texte imprimé Auteurs : Chih-Ping Chin, Auteur ; Ho-Shing Wu, Auteur ; Shaw S. Wang, Auteur Année de publication : 2011 Article en page(s) : pp. 7637-7643 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Pesticides Résumé : In pharmacology, development of a formulated nanosuspension, a potential drug delivery system for poorly soluble drugs, has been investigated to overcome the bioavailability problems caused by weak solubility, limited chemical stability following administration (i.e., a short half-life), poor bioavailability, and potentially strong side effects requiring drug enrichment at the site of action. For first time use in a pesticide delivery system, a two-step milling process for preparing a nanosuspension in a system of active compound/surfactant/water is described in this paper. First, all the components were mixed at a certain composition to prepare a microsuspension by the general milling process. Then, the microsuspension was taken into a nanomilling process with zirconium oxide beads, having a diameter range of 0.1―0.2 mm, as the milling media to generate the nanosuspension. Therefore, a nanosuspension concentrate was formed. To demonstrate the potential applications of this novel system, it was used to make a formulation with a poorly soluble crystalline insecticide, carbofuran. In a comparative study, two kinds of carbofuran formulations, a microsuspension (commercial) and a nanosuspension, were administered to a diamondback moth (DBM) to test their efficacy and stability as a pesticide. The results indicate that carbofuran has the same efficacy at a lower dose for the nanosuspension compared to the microsuspension. The nanosuspension system was also physically and chemically stable over a period of 2 years, as indicated by the unchanged particle size and specification tests. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24239080 [article] New approach to pesticide delivery using nanosuspensions : research and applications [texte imprimé] / Chih-Ping Chin, Auteur ; Ho-Shing Wu, Auteur ; Shaw S. Wang, Auteur . - 2011 . - pp. 7637-7643. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 12 (Juin 2011) . - pp. 7637-7643 Mots-clés : Pesticides Résumé : In pharmacology, development of a formulated nanosuspension, a potential drug delivery system for poorly soluble drugs, has been investigated to overcome the bioavailability problems caused by weak solubility, limited chemical stability following administration (i.e., a short half-life), poor bioavailability, and potentially strong side effects requiring drug enrichment at the site of action. For first time use in a pesticide delivery system, a two-step milling process for preparing a nanosuspension in a system of active compound/surfactant/water is described in this paper. First, all the components were mixed at a certain composition to prepare a microsuspension by the general milling process. Then, the microsuspension was taken into a nanomilling process with zirconium oxide beads, having a diameter range of 0.1―0.2 mm, as the milling media to generate the nanosuspension. Therefore, a nanosuspension concentrate was formed. To demonstrate the potential applications of this novel system, it was used to make a formulation with a poorly soluble crystalline insecticide, carbofuran. In a comparative study, two kinds of carbofuran formulations, a microsuspension (commercial) and a nanosuspension, were administered to a diamondback moth (DBM) to test their efficacy and stability as a pesticide. The results indicate that carbofuran has the same efficacy at a lower dose for the nanosuspension compared to the microsuspension. The nanosuspension system was also physically and chemically stable over a period of 2 years, as indicated by the unchanged particle size and specification tests. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24239080

Study on the performance of lambda cyhalothrin microemulsion with biodiesel as an alternative solvent / Chih-Ping Chin in Industrial & engineering chemistry research, Vol. 51 N° 12 (Mars 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 12 (Mars 2012) . - pp. 4710–4718 Titre : Study on the performance of lambda cyhalothrin microemulsion with biodiesel as an alternative solvent Type de document : texte imprimé Auteurs : Chih-Ping Chin, Auteur ; Chi-Wei Lan, Auteur ; Ho-Shing Wu, Auteur Année de publication : 2012 Article en page(s) : pp. 4710–4718 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Microemulsion  Biodiesel  Solvent Résumé : This study investigates a lambda cyhalothrin 2.5% (w/w) microemulsion formulation, with biodiesel as an alternative solvent, as a potential pesticide delivery system for oil-soluble pesticide active ingredients (AIs). This study presents a pseudoternary phase diagram of the investigated system, at room temperature by titration, and the surfactant/cosurfactant mass ratios (S/C), the oil-to-surfactant/cosurfactant mass ratios (O/SC) and the optimum formulation. This study also investigates the continuous structural inversion from water-in-oil to oil-in-water microemulsions after dilution with the water phase. The electrical conductivities of the selected system at constant S/C (5:1) and O/SC (1:1.2) ratios with biodiesel were also studied, and the percolation phenomenon was observed. The study examines the performance and stability of a formulation with biodiesel in comparison to commercial formulations. Residue and phytotoxicity tests were carried out on cabbage plants in a greenhouse. Experimental results indicate that biodiesel has good handling characteristics when it forms a microemulsion. The microemulsion formulation, with biodiesel as a solvent, had an acceptable transparent appearance, broader transparency temperature range, and better performance and stability than the commercial formulation. Using biodiesel in a pesticide formulation had no adverse effects on the AI activity and is comparatively safe for crops and plants. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie201151p [article] Study on the performance of lambda cyhalothrin microemulsion with biodiesel as an alternative solvent [texte imprimé] / Chih-Ping Chin, Auteur ; Chi-Wei Lan, Auteur ; Ho-Shing Wu, Auteur . - 2012 . - pp. 4710–4718. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 12 (Mars 2012) . - pp. 4710–4718 Mots-clés : Microemulsion  Biodiesel  Solvent Résumé : This study investigates a lambda cyhalothrin 2.5% (w/w) microemulsion formulation, with biodiesel as an alternative solvent, as a potential pesticide delivery system for oil-soluble pesticide active ingredients (AIs). This study presents a pseudoternary phase diagram of the investigated system, at room temperature by titration, and the surfactant/cosurfactant mass ratios (S/C), the oil-to-surfactant/cosurfactant mass ratios (O/SC) and the optimum formulation. This study also investigates the continuous structural inversion from water-in-oil to oil-in-water microemulsions after dilution with the water phase. The electrical conductivities of the selected system at constant S/C (5:1) and O/SC (1:1.2) ratios with biodiesel were also studied, and the percolation phenomenon was observed. The study examines the performance and stability of a formulation with biodiesel in comparison to commercial formulations. Residue and phytotoxicity tests were carried out on cabbage plants in a greenhouse. Experimental results indicate that biodiesel has good handling characteristics when it forms a microemulsion. The microemulsion formulation, with biodiesel as a solvent, had an acceptable transparent appearance, broader transparency temperature range, and better performance and stability than the commercial formulation. Using biodiesel in a pesticide formulation had no adverse effects on the AI activity and is comparatively safe for crops and plants. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie201151p