Novel interpenetrating polymer network hydrogel microspheres of chitosan and poly (acrylamide) - grafted - guar gum for controlled release of ciprofloxacin / Praveen B. Kajjari in Industrial & engineering chemistry research, Vol. 50 N° 23 (Décembre 2011)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 50 N° 23 (Décembre 2011) . - pp. 13280–13287 Titre : Novel interpenetrating polymer network hydrogel microspheres of chitosan and poly (acrylamide) - grafted - guar gum for controlled release of ciprofloxacin Type de document : texte imprimé Auteurs : Praveen B. Kajjari, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur Année de publication : 2012 Article en page(s) : pp. 13280–13287 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Polymer Hydrogel Microspheres Résumé : Acrylamide-grafted-guar gum (pAAm-g-GG) was prepared and blended with chitosan (CS) to form interpenetrating polymer network (IPN) hydrogel microspheres by the emulsion cross-linking method using glutaraldehyde (GA) as a cross-linker. The microspheres encapsulated up to 74% of ciprofloxacin (CFX), an antibiotic drug, having a plasma half-life of 4 h and the release of CFX was extended up to 12 h. Scanning electron microscopy (SEM) confirmed their spherical structure with smooth surfaces; Fourier transform infrared spectroscopy (FTIR) confirmed the grafting reaction as well as chemical stability of CFX in the blend IPN hydrogel microspheres. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) techniques confirmed the molecular level dispersion of CFX in the matrix. Swelling of microspheres performed in pH 7.4 buffer media was used to understand the drug release kinetics. In vitro release of CFX in pH 1.2 and 7.4 media showed a dependence on blend composition of the IPN, extent of cross-linking as well as initial drug loading. In vitro release data was analyzed using empirical equations, namely, Korsmeyer–Peppas, to compute the diffusion exponent (n), whose value ranged between 0.19 and 0.33, indicating non-Fickian transport of CFX through the blend IPN hydrogel microspheres. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie2012856 [article] Novel interpenetrating polymer network hydrogel microspheres of chitosan and poly (acrylamide) - grafted - guar gum for controlled release of ciprofloxacin [texte imprimé] / Praveen B. Kajjari, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur . - 2012 . - pp. 13280–13287. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 23 (Décembre 2011) . - pp. 13280–13287 Mots-clés : Polymer Hydrogel Microspheres Résumé : Acrylamide-grafted-guar gum (pAAm-g-GG) was prepared and blended with chitosan (CS) to form interpenetrating polymer network (IPN) hydrogel microspheres by the emulsion cross-linking method using glutaraldehyde (GA) as a cross-linker. The microspheres encapsulated up to 74% of ciprofloxacin (CFX), an antibiotic drug, having a plasma half-life of 4 h and the release of CFX was extended up to 12 h. Scanning electron microscopy (SEM) confirmed their spherical structure with smooth surfaces; Fourier transform infrared spectroscopy (FTIR) confirmed the grafting reaction as well as chemical stability of CFX in the blend IPN hydrogel microspheres. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) techniques confirmed the molecular level dispersion of CFX in the matrix. Swelling of microspheres performed in pH 7.4 buffer media was used to understand the drug release kinetics. In vitro release of CFX in pH 1.2 and 7.4 media showed a dependence on blend composition of the IPN, extent of cross-linking as well as initial drug loading. In vitro release data was analyzed using empirical equations, namely, Korsmeyer–Peppas, to compute the diffusion exponent (n), whose value ranged between 0.19 and 0.33, indicating non-Fickian transport of CFX through the blend IPN hydrogel microspheres. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie2012856

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Semi-interpenetrating polymer network hydrogel blend microspheres of gelatin and hydroxyethyl cellulose for controlled release of theophylline / Praveen B. Kajjari in Industrial & engineering chemistry research, Vol. 50 N° 13 (Juillet 2011)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 50 N° 13 (Juillet 2011) . - pp. 7833-7840 Titre : Semi-interpenetrating polymer network hydrogel blend microspheres of gelatin and hydroxyethyl cellulose for controlled release of theophylline Type de document : texte imprimé Auteurs : Praveen B. Kajjari, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur Année de publication : 2011 Article en page(s) : pp. 7833-7840 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Microsphere Résumé : Semi-interpenetrating polymer network (semi-IPN) hydrogel blend microspheres of gelatin and hydroxyethyl cellulose were prepared by a water-in-oil (w/o) emulsion technique and used to investigate the controlled release (CR) of theophylline (THP), an antiasthamatic drug. About 74% encapsulation of THP was achieved, and the drug release profiles were analyzed in terms of gelatin and hydroxyethyl cellulose blend composition, amount of cross-linking agent, and percentage drug loading. Fourier transform infrared (FTIR) spectroscopy confirmed the formation of the IPN blend matrix, as well as chemical stability of the drug in the microsphere. The physical state of the drug in the IPN matrix as evaluated by differential scanning calorimetry (DSC) and X-ray diffraction (XRD) remained undisturbed. The size of the microspheres varied from 98 to 144 μm as measured by laser light scattering. Scanning electron microscopy (SEM) indicated the smooth surface morphology of the microspheres. Equilibrium and dynamic swelling of the microspheres in distilled water were measured to compute the diffusion coefficient (Dv) of the drug solution through the microspheres. The in vitro cumulative release data were analyzed using an empirical equation to compute the diffusion exponent (n), whose values suggest a non-Fickian mode of transport. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24332106 [article] Semi-interpenetrating polymer network hydrogel blend microspheres of gelatin and hydroxyethyl cellulose for controlled release of theophylline [texte imprimé] / Praveen B. Kajjari, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur . - 2011 . - pp. 7833-7840. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 13 (Juillet 2011) . - pp. 7833-7840 Mots-clés : Microsphere Résumé : Semi-interpenetrating polymer network (semi-IPN) hydrogel blend microspheres of gelatin and hydroxyethyl cellulose were prepared by a water-in-oil (w/o) emulsion technique and used to investigate the controlled release (CR) of theophylline (THP), an antiasthamatic drug. About 74% encapsulation of THP was achieved, and the drug release profiles were analyzed in terms of gelatin and hydroxyethyl cellulose blend composition, amount of cross-linking agent, and percentage drug loading. Fourier transform infrared (FTIR) spectroscopy confirmed the formation of the IPN blend matrix, as well as chemical stability of the drug in the microsphere. The physical state of the drug in the IPN matrix as evaluated by differential scanning calorimetry (DSC) and X-ray diffraction (XRD) remained undisturbed. The size of the microspheres varied from 98 to 144 μm as measured by laser light scattering. Scanning electron microscopy (SEM) indicated the smooth surface morphology of the microspheres. Equilibrium and dynamic swelling of the microspheres in distilled water were measured to compute the diffusion coefficient (Dv) of the drug solution through the microspheres. The in vitro cumulative release data were analyzed using an empirical equation to compute the diffusion exponent (n), whose values suggest a non-Fickian mode of transport. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24332106

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