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Novel interpenetrating polymer network hydrogel microspheres of chitosan and poly (acrylamide) - grafted - guar gum for controlled release of ciprofloxacin / Praveen B. Kajjari in Industrial & engineering chemistry research, Vol. 50 N° 23 (Décembre 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 23 (Décembre 2011) . - pp. 13280–13287 Titre : Novel interpenetrating polymer network hydrogel microspheres of chitosan and poly (acrylamide) - grafted - guar gum for controlled release of ciprofloxacin Type de document : texte imprimé Auteurs : Praveen B. Kajjari, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur Année de publication : 2012 Article en page(s) : pp. 13280–13287 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Polymer  Hydrogel  Microspheres Résumé : Acrylamide-grafted-guar gum (pAAm-g-GG) was prepared and blended with chitosan (CS) to form interpenetrating polymer network (IPN) hydrogel microspheres by the emulsion cross-linking method using glutaraldehyde (GA) as a cross-linker. The microspheres encapsulated up to 74% of ciprofloxacin (CFX), an antibiotic drug, having a plasma half-life of 4 h and the release of CFX was extended up to 12 h. Scanning electron microscopy (SEM) confirmed their spherical structure with smooth surfaces; Fourier transform infrared spectroscopy (FTIR) confirmed the grafting reaction as well as chemical stability of CFX in the blend IPN hydrogel microspheres. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) techniques confirmed the molecular level dispersion of CFX in the matrix. Swelling of microspheres performed in pH 7.4 buffer media was used to understand the drug release kinetics. In vitro release of CFX in pH 1.2 and 7.4 media showed a dependence on blend composition of the IPN, extent of cross-linking as well as initial drug loading. In vitro release data was analyzed using empirical equations, namely, Korsmeyer–Peppas, to compute the diffusion exponent (n), whose value ranged between 0.19 and 0.33, indicating non-Fickian transport of CFX through the blend IPN hydrogel microspheres. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie2012856 [article] Novel interpenetrating polymer network hydrogel microspheres of chitosan and poly (acrylamide) - grafted - guar gum for controlled release of ciprofloxacin [texte imprimé] / Praveen B. Kajjari, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur . - 2012 . - pp. 13280–13287. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 23 (Décembre 2011) . - pp. 13280–13287 Mots-clés : Polymer  Hydrogel  Microspheres Résumé : Acrylamide-grafted-guar gum (pAAm-g-GG) was prepared and blended with chitosan (CS) to form interpenetrating polymer network (IPN) hydrogel microspheres by the emulsion cross-linking method using glutaraldehyde (GA) as a cross-linker. The microspheres encapsulated up to 74% of ciprofloxacin (CFX), an antibiotic drug, having a plasma half-life of 4 h and the release of CFX was extended up to 12 h. Scanning electron microscopy (SEM) confirmed their spherical structure with smooth surfaces; Fourier transform infrared spectroscopy (FTIR) confirmed the grafting reaction as well as chemical stability of CFX in the blend IPN hydrogel microspheres. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) techniques confirmed the molecular level dispersion of CFX in the matrix. Swelling of microspheres performed in pH 7.4 buffer media was used to understand the drug release kinetics. In vitro release of CFX in pH 1.2 and 7.4 media showed a dependence on blend composition of the IPN, extent of cross-linking as well as initial drug loading. In vitro release data was analyzed using empirical equations, namely, Korsmeyer–Peppas, to compute the diffusion exponent (n), whose value ranged between 0.19 and 0.33, indicating non-Fickian transport of CFX through the blend IPN hydrogel microspheres. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie2012856

Novel pH - sensitive hydrogels prepared from the blends of poly(vinyl alcohol) with acrylic acid - graft - guar gum matrixes for isoniazid delivery / Anita G. Sullad in Industrial & engineering chemistry research, Vol. 49 N° 16 (Août 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 16 (Août 2010) . - pp. 7323–7329 Titre : Novel pH - sensitive hydrogels prepared from the blends of poly(vinyl alcohol) with acrylic acid - graft - guar gum matrixes for isoniazid delivery Type de document : texte imprimé Auteurs : Anita G. Sullad, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur Année de publication : 2010 Article en page(s) : pp. 7323–7329 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Hydrogels Résumé : A novel type of pH-sensitive hydrogel blend of poly(vinyl alcohol) with acrylic acid-graft-guar gum has been prepared. Microspheres with a size of 10 μm were produced by the water-in-oil (w/o) emulsification method for investigating the controlled release of an antituberculosis drug, isoniazid. These novel carriers were analyzed for surface morphology, size, effect of pH, swelling, drug loading, and in vitro release of isoniazid in pH 1.2 and 7.4 media. The kinetics of drug release was analyzed using empirical equations. Release times of the drug were increased to 8 h from its nascent plasma half-life of 0.5−1.6 h. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie100389v [article] Novel pH - sensitive hydrogels prepared from the blends of poly(vinyl alcohol) with acrylic acid - graft - guar gum matrixes for isoniazid delivery [texte imprimé] / Anita G. Sullad, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur . - 2010 . - pp. 7323–7329. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 16 (Août 2010) . - pp. 7323–7329 Mots-clés : Hydrogels Résumé : A novel type of pH-sensitive hydrogel blend of poly(vinyl alcohol) with acrylic acid-graft-guar gum has been prepared. Microspheres with a size of 10 μm were produced by the water-in-oil (w/o) emulsification method for investigating the controlled release of an antituberculosis drug, isoniazid. These novel carriers were analyzed for surface morphology, size, effect of pH, swelling, drug loading, and in vitro release of isoniazid in pH 1.2 and 7.4 media. The kinetics of drug release was analyzed using empirical equations. Release times of the drug were increased to 8 h from its nascent plasma half-life of 0.5−1.6 h. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie100389v

Novel semi - interpenetrating microspheres of dextran - grafted - acrylamide and poly (vinyl alcohol) for controlled release of abacavir sulfate / Anita G. Sullad in Industrial & engineering chemistry research, Vol. 50 N° 21 (Novembre 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 21 (Novembre 2011) . - pp. 11778–11784 Titre : Novel semi - interpenetrating microspheres of dextran - grafted - acrylamide and poly (vinyl alcohol) for controlled release of abacavir sulfate Type de document : texte imprimé Auteurs : Anita G. Sullad, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur Année de publication : 2011 Article en page(s) : pp. 11778–11784 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Microspheres  Dextran Résumé : A novel drug delivery system using semi-interpenetrating (semi-IPN) microspheres of dextran-grafted-acrylamide (Dex-g-AAm) and poly(vinyl alcohol) (PVA) was prepared in the size range of 80–100 μm by emulsion cross-linking for investigating controlled release (CR) of an anti-HIV agent, abacavir sulfate. The graft copolymer was confirmed by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The microspheres were characterized for morphology, swelling, and in vitro release of abacavir sulfate in pH 1.2 and 7.4 buffer media to display the effect of drug release in acidic and alkaline conditions. The kinetics of in vitro release was analyzed using the empirical equations to understand the nature of release mechanism. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie2006438 [article] Novel semi - interpenetrating microspheres of dextran - grafted - acrylamide and poly (vinyl alcohol) for controlled release of abacavir sulfate [texte imprimé] / Anita G. Sullad, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur . - 2011 . - pp. 11778–11784. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 21 (Novembre 2011) . - pp. 11778–11784 Mots-clés : Microspheres  Dextran Résumé : A novel drug delivery system using semi-interpenetrating (semi-IPN) microspheres of dextran-grafted-acrylamide (Dex-g-AAm) and poly(vinyl alcohol) (PVA) was prepared in the size range of 80–100 μm by emulsion cross-linking for investigating controlled release (CR) of an anti-HIV agent, abacavir sulfate. The graft copolymer was confirmed by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The microspheres were characterized for morphology, swelling, and in vitro release of abacavir sulfate in pH 1.2 and 7.4 buffer media to display the effect of drug release in acidic and alkaline conditions. The kinetics of in vitro release was analyzed using the empirical equations to understand the nature of release mechanism. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie2006438

Semi-interpenetrating polymer network hydrogel blend microspheres of gelatin and hydroxyethyl cellulose for controlled release of theophylline / Praveen B. Kajjari in Industrial & engineering chemistry research, Vol. 50 N° 13 (Juillet 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 13 (Juillet 2011) . - pp. 7833-7840 Titre : Semi-interpenetrating polymer network hydrogel blend microspheres of gelatin and hydroxyethyl cellulose for controlled release of theophylline Type de document : texte imprimé Auteurs : Praveen B. Kajjari, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur Année de publication : 2011 Article en page(s) : pp. 7833-7840 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Microsphere Résumé : Semi-interpenetrating polymer network (semi-IPN) hydrogel blend microspheres of gelatin and hydroxyethyl cellulose were prepared by a water-in-oil (w/o) emulsion technique and used to investigate the controlled release (CR) of theophylline (THP), an antiasthamatic drug. About 74% encapsulation of THP was achieved, and the drug release profiles were analyzed in terms of gelatin and hydroxyethyl cellulose blend composition, amount of cross-linking agent, and percentage drug loading. Fourier transform infrared (FTIR) spectroscopy confirmed the formation of the IPN blend matrix, as well as chemical stability of the drug in the microsphere. The physical state of the drug in the IPN matrix as evaluated by differential scanning calorimetry (DSC) and X-ray diffraction (XRD) remained undisturbed. The size of the microspheres varied from 98 to 144 μm as measured by laser light scattering. Scanning electron microscopy (SEM) indicated the smooth surface morphology of the microspheres. Equilibrium and dynamic swelling of the microspheres in distilled water were measured to compute the diffusion coefficient (Dv) of the drug solution through the microspheres. The in vitro cumulative release data were analyzed using an empirical equation to compute the diffusion exponent (n), whose values suggest a non-Fickian mode of transport. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24332106 [article] Semi-interpenetrating polymer network hydrogel blend microspheres of gelatin and hydroxyethyl cellulose for controlled release of theophylline [texte imprimé] / Praveen B. Kajjari, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur . - 2011 . - pp. 7833-7840. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 13 (Juillet 2011) . - pp. 7833-7840 Mots-clés : Microsphere Résumé : Semi-interpenetrating polymer network (semi-IPN) hydrogel blend microspheres of gelatin and hydroxyethyl cellulose were prepared by a water-in-oil (w/o) emulsion technique and used to investigate the controlled release (CR) of theophylline (THP), an antiasthamatic drug. About 74% encapsulation of THP was achieved, and the drug release profiles were analyzed in terms of gelatin and hydroxyethyl cellulose blend composition, amount of cross-linking agent, and percentage drug loading. Fourier transform infrared (FTIR) spectroscopy confirmed the formation of the IPN blend matrix, as well as chemical stability of the drug in the microsphere. The physical state of the drug in the IPN matrix as evaluated by differential scanning calorimetry (DSC) and X-ray diffraction (XRD) remained undisturbed. The size of the microspheres varied from 98 to 144 μm as measured by laser light scattering. Scanning electron microscopy (SEM) indicated the smooth surface morphology of the microspheres. Equilibrium and dynamic swelling of the microspheres in distilled water were measured to compute the diffusion coefficient (Dv) of the drug solution through the microspheres. The in vitro cumulative release data were analyzed using an empirical equation to compute the diffusion exponent (n), whose values suggest a non-Fickian mode of transport. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24332106

Stearic acid-coated chitosan-based interpenetrating polymer network microspheres / Sudha C. Angadi in Industrial & engineering chemistry research, Vol. 50 N° 8 (Avril 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 8 (Avril 2011) . - pp. 4504–4514 Titre : Stearic acid-coated chitosan-based interpenetrating polymer network microspheres : controlled release characteristics Type de document : texte imprimé Auteurs : Sudha C. Angadi, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur Année de publication : 2011 Article en page(s) : pp. 4504–4514 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Stearic  acid  Polymer Résumé : Novel pH-sensitive stearic acid-coated interpenetrating polymer network (IPN) blend microspheres of chitosan and gelatin were prepared by the emulsion cross-linking method using glutaraldehyde for the controlled release (CR) of isoniazid (INH), an antituberculosis drug. Coated as well as uncoated microspheres were developed and characterized by Fourier transform infrared (FTIR) to understand the chemical interactions and formation of the IPN blend structure as well as to confirm successful coating with the stearic acid. X-ray diffraction (XRD) indicated the distribution of INH, while differential scanning calorimetry (DSC) was used for investigating the thermal stability of the IPN blend matrices. Scanning electron microscopy (SEM) was used to distinguish between the morphologies of coated and uncoated microspheres. Coated microspheres were produced in the size range of 52 μm down to 502 nm with encapsulation efficiencies of 65−78%. Equilibrium swelling was studied in pH 1.2 and pH 7.4 buffer media, and the in vitro drug release showed the dependence of drug release on the cross-linking, blend ratio of the IPN matrix as well as stearic acid coating. The variations in the IPN blend ratio and cross-link density controlled the drug release up to 30 h, but the coated microspheres could reduce the burst release in the gastric stomach media, while enhancing in intestinal pH 7.4 media. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie102479m [article] Stearic acid-coated chitosan-based interpenetrating polymer network microspheres : controlled release characteristics [texte imprimé] / Sudha C. Angadi, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur . - 2011 . - pp. 4504–4514. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 8 (Avril 2011) . - pp. 4504–4514 Mots-clés : Stearic  acid  Polymer Résumé : Novel pH-sensitive stearic acid-coated interpenetrating polymer network (IPN) blend microspheres of chitosan and gelatin were prepared by the emulsion cross-linking method using glutaraldehyde for the controlled release (CR) of isoniazid (INH), an antituberculosis drug. Coated as well as uncoated microspheres were developed and characterized by Fourier transform infrared (FTIR) to understand the chemical interactions and formation of the IPN blend structure as well as to confirm successful coating with the stearic acid. X-ray diffraction (XRD) indicated the distribution of INH, while differential scanning calorimetry (DSC) was used for investigating the thermal stability of the IPN blend matrices. Scanning electron microscopy (SEM) was used to distinguish between the morphologies of coated and uncoated microspheres. Coated microspheres were produced in the size range of 52 μm down to 502 nm with encapsulation efficiencies of 65−78%. Equilibrium swelling was studied in pH 1.2 and pH 7.4 buffer media, and the in vitro drug release showed the dependence of drug release on the cross-linking, blend ratio of the IPN matrix as well as stearic acid coating. The variations in the IPN blend ratio and cross-link density controlled the drug release up to 30 h, but the coated microspheres could reduce the burst release in the gastric stomach media, while enhancing in intestinal pH 7.4 media. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie102479m