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Blend microspheres of poly(3-hydroxybutyrate) and cellulose acetate phthalate for colon delivery of 5-fluorouracil / Kiran Chaturvedi in Industrial & engineering chemistry research, Vol. 50 N° 18 (Septembre 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 18 (Septembre 2011) . - pp. 10414-10423 Titre : Blend microspheres of poly(3-hydroxybutyrate) and cellulose acetate phthalate for colon delivery of 5-fluorouracil Type de document : texte imprimé Auteurs : Kiran Chaturvedi, Auteur ; Anandrao R. Kulkarni, Auteur ; Tejraj M. Aminabhavi, Auteur Année de publication : 2011 Article en page(s) : pp. 10414-10423 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Microsphere Résumé : Blend microspheres of poly(3-hydroxybutyrate) (PHB) and cellulose acetate phthalate (CAP) have been prepared in compositions of 2:1, 1:1, and 1:3 (w/w) by the solvent evaporation technique. These pH-sensitive polymers were utilized to investigate the colon delivery of 5-fluorouracil (5-FU), an anticancer drug. The surface morphology of the microspheres was studied by scanning electron microscopy (SEM), which confirmed their spherical nature with sizes ranging from 29 to 67 μm, as well as pore structures before and after the dissolution experiments. Fourier transform infrared (FTIR) spectroscopy was used to confirm the polymer blend compatibility and to confirm the absence of drug–polymer interactions. Differential scanning calorimetry (DSC) was employed to study the crystalline nature and molecular-level dispersion of 5-FU in the matrixes after encapsulation. In vitro release experiments were performed at 37 °C in simulated buffer medium of the stomach (pH 1.2) for 2 h, followed by simulated intestinal medium (pH 7.4). It was found that the release of 5-FU from blend microspheres followed pH-dependent release as compared to that of plain PHB microspheres. From the in vitro release studies, it was found that blend microspheres are more efficient at delivering 5-FU to the colon than plain PHB microspheres. Furthermore, release data were fitted to empirical equations to understand the nature of the drug release profiles. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24523863 [article] Blend microspheres of poly(3-hydroxybutyrate) and cellulose acetate phthalate for colon delivery of 5-fluorouracil [texte imprimé] / Kiran Chaturvedi, Auteur ; Anandrao R. Kulkarni, Auteur ; Tejraj M. Aminabhavi, Auteur . - 2011 . - pp. 10414-10423. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 18 (Septembre 2011) . - pp. 10414-10423 Mots-clés : Microsphere Résumé : Blend microspheres of poly(3-hydroxybutyrate) (PHB) and cellulose acetate phthalate (CAP) have been prepared in compositions of 2:1, 1:1, and 1:3 (w/w) by the solvent evaporation technique. These pH-sensitive polymers were utilized to investigate the colon delivery of 5-fluorouracil (5-FU), an anticancer drug. The surface morphology of the microspheres was studied by scanning electron microscopy (SEM), which confirmed their spherical nature with sizes ranging from 29 to 67 μm, as well as pore structures before and after the dissolution experiments. Fourier transform infrared (FTIR) spectroscopy was used to confirm the polymer blend compatibility and to confirm the absence of drug–polymer interactions. Differential scanning calorimetry (DSC) was employed to study the crystalline nature and molecular-level dispersion of 5-FU in the matrixes after encapsulation. In vitro release experiments were performed at 37 °C in simulated buffer medium of the stomach (pH 1.2) for 2 h, followed by simulated intestinal medium (pH 7.4). It was found that the release of 5-FU from blend microspheres followed pH-dependent release as compared to that of plain PHB microspheres. From the in vitro release studies, it was found that blend microspheres are more efficient at delivering 5-FU to the colon than plain PHB microspheres. Furthermore, release data were fitted to empirical equations to understand the nature of the drug release profiles. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24523863

Colon targeting of 5 - fluorouracil using polyethylene glycol cross - linked chitosan microspheres enteric coated with cellulose acetate phthalate / Kuntal Ganguly in Industrial & engineering chemistry research, Vol. 50 N° 21 (Novembre 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 21 (Novembre 2011) . - pp. 11797-11807 Titre : Colon targeting of 5 - fluorouracil using polyethylene glycol cross - linked chitosan microspheres enteric coated with cellulose acetate phthalate Type de document : texte imprimé Auteurs : Kuntal Ganguly, Auteur ; Tejraj M. Aminabhavi, Auteur ; Anandrao R. Kulkarni, Auteur Année de publication : 2011 Article en page(s) : pp. 11797-11807 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Microsphere Résumé : Polyethylene glycol cross-linked chitosan microspheres loaded with 5-fluorouracil (5-FU) have been prepared by emulsion cross-linking and enteric coated with cellulose acetate phthalate (CAP) to facilitate direct targeting of S-FU to the colon. Spherical microspheres with surface ridges to moderate smooth surfaces loaded with different concentrations (i.e., 10, 20, and 30% w/w) of 5-FU have been evaluated for encapsulation efficiency, swelling and in vitro release characteristics in simulated gastro intestinal tract (GIT) conditions for both enteric coated and uncoated microspheres. In acidic pH, 8 to 17%, but in alkaline pH, approximately 88 to 97% of 5-FU was released with CAP coated microspheres. In the case of uncoated microspheres, 46 to 77% release of 5-FU occurred in acidic pH, but 93 to 97% was released in alkaline pH. The study demonstrates that chitosan coating with CAP and cross-linking with PEG is necessary for targeted delivery of 5-FU to the colon. The coated microspheres are found to be more suitable for colon targeting than the uncoated formulations as the former prolonged the 5-FU release from 6 to 12 h by protecting 5-FU in acidic environment of the stomach. Kinetics of drug release as investigated by empirical equations suggested Super Case II transport mechanism. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24697495 [article] Colon targeting of 5 - fluorouracil using polyethylene glycol cross - linked chitosan microspheres enteric coated with cellulose acetate phthalate [texte imprimé] / Kuntal Ganguly, Auteur ; Tejraj M. Aminabhavi, Auteur ; Anandrao R. Kulkarni, Auteur . - 2011 . - pp. 11797-11807. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 21 (Novembre 2011) . - pp. 11797-11807 Mots-clés : Microsphere Résumé : Polyethylene glycol cross-linked chitosan microspheres loaded with 5-fluorouracil (5-FU) have been prepared by emulsion cross-linking and enteric coated with cellulose acetate phthalate (CAP) to facilitate direct targeting of S-FU to the colon. Spherical microspheres with surface ridges to moderate smooth surfaces loaded with different concentrations (i.e., 10, 20, and 30% w/w) of 5-FU have been evaluated for encapsulation efficiency, swelling and in vitro release characteristics in simulated gastro intestinal tract (GIT) conditions for both enteric coated and uncoated microspheres. In acidic pH, 8 to 17%, but in alkaline pH, approximately 88 to 97% of 5-FU was released with CAP coated microspheres. In the case of uncoated microspheres, 46 to 77% release of 5-FU occurred in acidic pH, but 93 to 97% was released in alkaline pH. The study demonstrates that chitosan coating with CAP and cross-linking with PEG is necessary for targeted delivery of 5-FU to the colon. The coated microspheres are found to be more suitable for colon targeting than the uncoated formulations as the former prolonged the 5-FU release from 6 to 12 h by protecting 5-FU in acidic environment of the stomach. Kinetics of drug release as investigated by empirical equations suggested Super Case II transport mechanism. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24697495

Novel interpenetrating polymer network hydrogel microspheres of chitosan and poly (acrylamide) - grafted - guar gum for controlled release of ciprofloxacin / Praveen B. Kajjari in Industrial & engineering chemistry research, Vol. 50 N° 23 (Décembre 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 23 (Décembre 2011) . - pp. 13280–13287 Titre : Novel interpenetrating polymer network hydrogel microspheres of chitosan and poly (acrylamide) - grafted - guar gum for controlled release of ciprofloxacin Type de document : texte imprimé Auteurs : Praveen B. Kajjari, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur Année de publication : 2012 Article en page(s) : pp. 13280–13287 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Polymer  Hydrogel  Microspheres Résumé : Acrylamide-grafted-guar gum (pAAm-g-GG) was prepared and blended with chitosan (CS) to form interpenetrating polymer network (IPN) hydrogel microspheres by the emulsion cross-linking method using glutaraldehyde (GA) as a cross-linker. The microspheres encapsulated up to 74% of ciprofloxacin (CFX), an antibiotic drug, having a plasma half-life of 4 h and the release of CFX was extended up to 12 h. Scanning electron microscopy (SEM) confirmed their spherical structure with smooth surfaces; Fourier transform infrared spectroscopy (FTIR) confirmed the grafting reaction as well as chemical stability of CFX in the blend IPN hydrogel microspheres. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) techniques confirmed the molecular level dispersion of CFX in the matrix. Swelling of microspheres performed in pH 7.4 buffer media was used to understand the drug release kinetics. In vitro release of CFX in pH 1.2 and 7.4 media showed a dependence on blend composition of the IPN, extent of cross-linking as well as initial drug loading. In vitro release data was analyzed using empirical equations, namely, Korsmeyer–Peppas, to compute the diffusion exponent (n), whose value ranged between 0.19 and 0.33, indicating non-Fickian transport of CFX through the blend IPN hydrogel microspheres. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie2012856 [article] Novel interpenetrating polymer network hydrogel microspheres of chitosan and poly (acrylamide) - grafted - guar gum for controlled release of ciprofloxacin [texte imprimé] / Praveen B. Kajjari, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur . - 2012 . - pp. 13280–13287. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 23 (Décembre 2011) . - pp. 13280–13287 Mots-clés : Polymer  Hydrogel  Microspheres Résumé : Acrylamide-grafted-guar gum (pAAm-g-GG) was prepared and blended with chitosan (CS) to form interpenetrating polymer network (IPN) hydrogel microspheres by the emulsion cross-linking method using glutaraldehyde (GA) as a cross-linker. The microspheres encapsulated up to 74% of ciprofloxacin (CFX), an antibiotic drug, having a plasma half-life of 4 h and the release of CFX was extended up to 12 h. Scanning electron microscopy (SEM) confirmed their spherical structure with smooth surfaces; Fourier transform infrared spectroscopy (FTIR) confirmed the grafting reaction as well as chemical stability of CFX in the blend IPN hydrogel microspheres. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) techniques confirmed the molecular level dispersion of CFX in the matrix. Swelling of microspheres performed in pH 7.4 buffer media was used to understand the drug release kinetics. In vitro release of CFX in pH 1.2 and 7.4 media showed a dependence on blend composition of the IPN, extent of cross-linking as well as initial drug loading. In vitro release data was analyzed using empirical equations, namely, Korsmeyer–Peppas, to compute the diffusion exponent (n), whose value ranged between 0.19 and 0.33, indicating non-Fickian transport of CFX through the blend IPN hydrogel microspheres. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie2012856

Novel pH - sensitive hydrogels prepared from the blends of poly(vinyl alcohol) with acrylic acid - graft - guar gum matrixes for isoniazid delivery / Anita G. Sullad in Industrial & engineering chemistry research, Vol. 49 N° 16 (Août 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 16 (Août 2010) . - pp. 7323–7329 Titre : Novel pH - sensitive hydrogels prepared from the blends of poly(vinyl alcohol) with acrylic acid - graft - guar gum matrixes for isoniazid delivery Type de document : texte imprimé Auteurs : Anita G. Sullad, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur Année de publication : 2010 Article en page(s) : pp. 7323–7329 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Hydrogels Résumé : A novel type of pH-sensitive hydrogel blend of poly(vinyl alcohol) with acrylic acid-graft-guar gum has been prepared. Microspheres with a size of 10 μm were produced by the water-in-oil (w/o) emulsification method for investigating the controlled release of an antituberculosis drug, isoniazid. These novel carriers were analyzed for surface morphology, size, effect of pH, swelling, drug loading, and in vitro release of isoniazid in pH 1.2 and 7.4 media. The kinetics of drug release was analyzed using empirical equations. Release times of the drug were increased to 8 h from its nascent plasma half-life of 0.5−1.6 h. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie100389v [article] Novel pH - sensitive hydrogels prepared from the blends of poly(vinyl alcohol) with acrylic acid - graft - guar gum matrixes for isoniazid delivery [texte imprimé] / Anita G. Sullad, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur . - 2010 . - pp. 7323–7329. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 16 (Août 2010) . - pp. 7323–7329 Mots-clés : Hydrogels Résumé : A novel type of pH-sensitive hydrogel blend of poly(vinyl alcohol) with acrylic acid-graft-guar gum has been prepared. Microspheres with a size of 10 μm were produced by the water-in-oil (w/o) emulsification method for investigating the controlled release of an antituberculosis drug, isoniazid. These novel carriers were analyzed for surface morphology, size, effect of pH, swelling, drug loading, and in vitro release of isoniazid in pH 1.2 and 7.4 media. The kinetics of drug release was analyzed using empirical equations. Release times of the drug were increased to 8 h from its nascent plasma half-life of 0.5−1.6 h. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie100389v

Novel semi - interpenetrating microspheres of dextran - grafted - acrylamide and poly (vinyl alcohol) for controlled release of abacavir sulfate / Anita G. Sullad in Industrial & engineering chemistry research, Vol. 50 N° 21 (Novembre 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 21 (Novembre 2011) . - pp. 11778–11784 Titre : Novel semi - interpenetrating microspheres of dextran - grafted - acrylamide and poly (vinyl alcohol) for controlled release of abacavir sulfate Type de document : texte imprimé Auteurs : Anita G. Sullad, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur Année de publication : 2011 Article en page(s) : pp. 11778–11784 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Microspheres  Dextran Résumé : A novel drug delivery system using semi-interpenetrating (semi-IPN) microspheres of dextran-grafted-acrylamide (Dex-g-AAm) and poly(vinyl alcohol) (PVA) was prepared in the size range of 80–100 μm by emulsion cross-linking for investigating controlled release (CR) of an anti-HIV agent, abacavir sulfate. The graft copolymer was confirmed by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The microspheres were characterized for morphology, swelling, and in vitro release of abacavir sulfate in pH 1.2 and 7.4 buffer media to display the effect of drug release in acidic and alkaline conditions. The kinetics of in vitro release was analyzed using the empirical equations to understand the nature of release mechanism. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie2006438 [article] Novel semi - interpenetrating microspheres of dextran - grafted - acrylamide and poly (vinyl alcohol) for controlled release of abacavir sulfate [texte imprimé] / Anita G. Sullad, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur . - 2011 . - pp. 11778–11784. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 21 (Novembre 2011) . - pp. 11778–11784 Mots-clés : Microspheres  Dextran Résumé : A novel drug delivery system using semi-interpenetrating (semi-IPN) microspheres of dextran-grafted-acrylamide (Dex-g-AAm) and poly(vinyl alcohol) (PVA) was prepared in the size range of 80–100 μm by emulsion cross-linking for investigating controlled release (CR) of an anti-HIV agent, abacavir sulfate. The graft copolymer was confirmed by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The microspheres were characterized for morphology, swelling, and in vitro release of abacavir sulfate in pH 1.2 and 7.4 buffer media to display the effect of drug release in acidic and alkaline conditions. The kinetics of in vitro release was analyzed using the empirical equations to understand the nature of release mechanism. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie2006438

Semi-interpenetrating polymer network hydrogel blend microspheres of gelatin and hydroxyethyl cellulose for controlled release of theophylline / Praveen B. Kajjari in Industrial & engineering chemistry research, Vol. 50 N° 13 (Juillet 2011) 

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Stearic acid-coated chitosan-based interpenetrating polymer network microspheres / Sudha C. Angadi in Industrial & engineering chemistry research, Vol. 50 N° 8 (Avril 2011) 

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