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High throughput methodology for continuous preparation of hydroxyapatite nanoparticles in a microporous tube-in-tube microchannel reactor / Qing Yang in Industrial & engineering chemistry research, Vol. 49 N° 1 (Janvier 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 1 (Janvier 2010) . - pp. 140–147 Titre : High throughput methodology for continuous preparation of hydroxyapatite nanoparticles in a microporous tube-in-tube microchannel reactor Type de document : texte imprimé Auteurs : Qing Yang, Auteur ; Jie - Xin Wang, Auteur ; Lei Shao, Auteur Année de publication : 2010 Article en page(s) : pp. 140–147 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Throughput--Methodology--Continuous--Hydroxyapatite--Nanoparticles--Microporous--Tube-in-Tube--Microchannel  Reactor Résumé : A microporous tube-in-tube microchannel reactor (MTMCR) was successfully adopted to prepare hydroxyapatite (HAP) nanoparticles. The rodlike HAP nanoparticles with a mean size of 58 nm, a specific surface area of 49.32 m2/g, and a narrow size distribution were obtained in an MTMCR under a high throughput of 3 L/min. The mean particle size sharply decreased with increasing the continuous phase flow rate, while first decreased and subsequently increased with increasing the dispersed phase flow rate and the reactant concentration. The extension of the mixing distance led to the initial rapid and following slight decrease of the mean particle size. The size of HAP nanoparticles was also strongly dependent on the micropore size on the surface of inner tube. Small micropore size was beneficial for producing small particles. For comparison, HAP nanoparticles were also prepared in a stirred tank reactor (STR) and a T-junction microchannel reactor (TMCR), clearly exhibiting the advantages of the MTMCR over the STR and TMCR due to the achievement of uniformly smaller HAP nanoparticles and a high throughput for industrial production. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9005436 [article] High throughput methodology for continuous preparation of hydroxyapatite nanoparticles in a microporous tube-in-tube microchannel reactor [texte imprimé] / Qing Yang, Auteur ; Jie - Xin Wang, Auteur ; Lei Shao, Auteur . - 2010 . - pp. 140–147. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 1 (Janvier 2010) . - pp. 140–147 Mots-clés : Throughput--Methodology--Continuous--Hydroxyapatite--Nanoparticles--Microporous--Tube-in-Tube--Microchannel  Reactor Résumé : A microporous tube-in-tube microchannel reactor (MTMCR) was successfully adopted to prepare hydroxyapatite (HAP) nanoparticles. The rodlike HAP nanoparticles with a mean size of 58 nm, a specific surface area of 49.32 m2/g, and a narrow size distribution were obtained in an MTMCR under a high throughput of 3 L/min. The mean particle size sharply decreased with increasing the continuous phase flow rate, while first decreased and subsequently increased with increasing the dispersed phase flow rate and the reactant concentration. The extension of the mixing distance led to the initial rapid and following slight decrease of the mean particle size. The size of HAP nanoparticles was also strongly dependent on the micropore size on the surface of inner tube. Small micropore size was beneficial for producing small particles. For comparison, HAP nanoparticles were also prepared in a stirred tank reactor (STR) and a T-junction microchannel reactor (TMCR), clearly exhibiting the advantages of the MTMCR over the STR and TMCR due to the achievement of uniformly smaller HAP nanoparticles and a high throughput for industrial production. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9005436

Microfluidic fabrication of monodispersed pharmaceutical colloidal spheres of atorvastatin calcium with tunable sizes / Hai-Xia Zhang in Industrial & engineering chemistry research, Vol. 49 N° 9 (Mai 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 9 (Mai 2010) . - pp. 4156–4161 Titre : Microfluidic fabrication of monodispersed pharmaceutical colloidal spheres of atorvastatin calcium with tunable sizes Type de document : texte imprimé Auteurs : Hai-Xia Zhang, Auteur ; Jie - Xin Wang, Auteur ; Lei Shao, Auteur Année de publication : 2010 Article en page(s) : pp. 4156–4161 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Microfluidic Résumé : In this work, monodispersed pharmaceutical colloidal spheres of atorvastatin calcium (AC) with tunable sizes have been synthesized in a microfluidic system at continuous flow conditions. The influences of the key parameters, including the concentration of the AC methanol solution, the overall flow rate, the flow rate of isopropanol, and the flow rate of the AC methanol solution on particle size and size distribution were discussed. The results indicated that the drug concentration and the flow rate could efficiently control the particle size and improve the polydispersity of the resulting particles. The particle size decreased from 760 to 300 nm with an increase in the AC concentration from 30 to 60 mg/mL and significantly increased from 430 to 2500 nm with an increase in the flow rate of the AC methanol solution from 2.7 to 16 mL/min. However, with the increase of the overall flow rate at a fixed flow ratio of 10, the particle size slightly decreased from 240 (10/1 mL/min) to 210 nm (30/3 mL/min) and then dramatically increased to 680 nm (80/8 mL/min). Also, the particle size first decreased and then increased with an increase in the flow rate of isopropanol. The prepared AC colloidal spheres were amorphous and displayed enhanced dissolution rate compared with the commercial AC. This work shows that the continuous synthesis in a microfluidic reactor is a simple and economic way to prepare monodispersed pharmaceutical colloidal particles or nanoparticles with tunable sizes. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie901365w [article] Microfluidic fabrication of monodispersed pharmaceutical colloidal spheres of atorvastatin calcium with tunable sizes [texte imprimé] / Hai-Xia Zhang, Auteur ; Jie - Xin Wang, Auteur ; Lei Shao, Auteur . - 2010 . - pp. 4156–4161. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 9 (Mai 2010) . - pp. 4156–4161 Mots-clés : Microfluidic Résumé : In this work, monodispersed pharmaceutical colloidal spheres of atorvastatin calcium (AC) with tunable sizes have been synthesized in a microfluidic system at continuous flow conditions. The influences of the key parameters, including the concentration of the AC methanol solution, the overall flow rate, the flow rate of isopropanol, and the flow rate of the AC methanol solution on particle size and size distribution were discussed. The results indicated that the drug concentration and the flow rate could efficiently control the particle size and improve the polydispersity of the resulting particles. The particle size decreased from 760 to 300 nm with an increase in the AC concentration from 30 to 60 mg/mL and significantly increased from 430 to 2500 nm with an increase in the flow rate of the AC methanol solution from 2.7 to 16 mL/min. However, with the increase of the overall flow rate at a fixed flow ratio of 10, the particle size slightly decreased from 240 (10/1 mL/min) to 210 nm (30/3 mL/min) and then dramatically increased to 680 nm (80/8 mL/min). Also, the particle size first decreased and then increased with an increase in the flow rate of isopropanol. The prepared AC colloidal spheres were amorphous and displayed enhanced dissolution rate compared with the commercial AC. This work shows that the continuous synthesis in a microfluidic reactor is a simple and economic way to prepare monodispersed pharmaceutical colloidal particles or nanoparticles with tunable sizes. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie901365w

Removal of carbon dioxide by absorption in microporous tube-in-tube microchannel reactor / Na-Na Gao in Industrial & engineering chemistry research, Vol. 50 N° 10 (Mai 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 10 (Mai 2011) . - pp. 6369-6374 Titre : Removal of carbon dioxide by absorption in microporous tube-in-tube microchannel reactor Type de document : texte imprimé Auteurs : Na-Na Gao, Auteur ; Jie-Xin Wang, Auteur ; Lei Shao, Auteur Année de publication : 2011 Article en page(s) : pp. 6369-6374 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Microreactor  Microporosity  Carbon  dioxide Résumé : In this article, preliminary experimental results are presented on the absorption of carbon dioxide (CO2) in a novel high-throughput microporous tube-in-tube microchannel reactor (MTMCR), with an aqueous solution of monoethanolamine (MEA) and a mixture of CO2/N2 as the working fluids. The effects of design and operating parameters on the CO2 removal efficiency were investigated. The absorbent concentration was given the priority as a key factor for consideration, with the result that the CO2 removal efficiency increased with increasing concentrationan and could reach 90% or even higher at a high throughput of 440 L/h for gas with an MEA concentration of 30 wt %. With a decrease of the superficial gas velocity or an increase of the superficial liquid velocity, the CO2 removal efficiency increased. Increasing the absorbent temperature yielded better absorption performance. Reducing the most important structural parameters of the MTMCR, such as the micropore size and the annular channel width, led to ahigher mass-transfer rate and was beneficial for CO2 removal. This work also investigated the characteristics of the pressure drop of two-phase flows through the MTMCR. The results obtained imply a great potential for MTMCRs applied to the separation of the greenhouse gas CO2 from the exhausted gases. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24158933 [article] Removal of carbon dioxide by absorption in microporous tube-in-tube microchannel reactor [texte imprimé] / Na-Na Gao, Auteur ; Jie-Xin Wang, Auteur ; Lei Shao, Auteur . - 2011 . - pp. 6369-6374. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 10 (Mai 2011) . - pp. 6369-6374 Mots-clés : Microreactor  Microporosity  Carbon  dioxide Résumé : In this article, preliminary experimental results are presented on the absorption of carbon dioxide (CO2) in a novel high-throughput microporous tube-in-tube microchannel reactor (MTMCR), with an aqueous solution of monoethanolamine (MEA) and a mixture of CO2/N2 as the working fluids. The effects of design and operating parameters on the CO2 removal efficiency were investigated. The absorbent concentration was given the priority as a key factor for consideration, with the result that the CO2 removal efficiency increased with increasing concentrationan and could reach 90% or even higher at a high throughput of 440 L/h for gas with an MEA concentration of 30 wt %. With a decrease of the superficial gas velocity or an increase of the superficial liquid velocity, the CO2 removal efficiency increased. Increasing the absorbent temperature yielded better absorption performance. Reducing the most important structural parameters of the MTMCR, such as the micropore size and the annular channel width, led to ahigher mass-transfer rate and was beneficial for CO2 removal. This work also investigated the characteristics of the pressure drop of two-phase flows through the MTMCR. The results obtained imply a great potential for MTMCRs applied to the separation of the greenhouse gas CO2 from the exhausted gases. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24158933