| Titre : | Precipitation and transformation of the three polymorphs of d-mannitol (2010) |
| Auteurs : | Jeroen Cornel, Auteur ; Piran Kidambi, Auteur ; Mazzotti, Marco, Auteur |
| Type de document : | Article : texte imprimé |
| Dans : | Industrial & engineering chemistry research (Vol. 49 N° 12, Juin 2010) |
| Article en page(s) : | pp. 5854–5862 |
| Note générale : | Chemical engineering |
| Langues : | Anglais |
| Tags : | d-mannitol’s three polymorphs Thermodynamic aspects kinetic Solid-state forms |
| Résumé : | In this work, the thermodynamic and kinetic aspects of d-mannitol’s three polymorphs and their transformations are addressed. Scalable and reproducible syntheses of the solid-state forms are presented, and a mathematical model to describe a three-polymorph transformation is discussed in detail. It is shown that, for certain initial solute concentrations, the α polymorph nucleates first and then transforms through the β form to the γ form. Moreover, a supersaturation threshold to nucleate the α form has been observed, and below this threshold value, the γ form nucleates. A theoretical analysis demonstrates that this behavior can be predicted and that this experimental observation is physically sound. |
| En ligne : | http://pubs.acs.org/doi/abs/10.1021/ie9019616 |
