Modeling of drug (Albumin) release from thermosensitive chitosan hydrogels / Roman Zarzycki in Industrial & engineering chemistry research, Vol. 50 N° 9 (Mai 2011)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 50 N° 9 (Mai 2011) . - pp. 5866-5872 Titre : Modeling of drug (Albumin) release from thermosensitive chitosan hydrogels Type de document : texte imprimé Auteurs : Roman Zarzycki, Auteur ; Grzegorz Rogacki, Auteur ; Zofia Modrzejewska, Auteur Année de publication : 2011 Article en page(s) : pp. 5866-5872 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Modeling Résumé : A theoretical model of drug release in hydrogels was designed taking into account desorption processes on the solid phase surface and diffusion in pores. The model describes kinetics with two constant parameters independent of concentration and time: DAB, the diffusion coefficient of component A in the liquid, and k, the transfer coefficient describing the rate of desorption of component A. The model was verified using experimental data concerning the release of bovine albumin from thermosensitive chitosan gels. The process of albumin release from hydrogels produced from chitosan glutamate can be described by parameters DAB = 2.0 × 10―9 m2/s and k= 1.02 x 10―6 m/s. Calculations based on the model prove that it properly correlates experimental data. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24128713 [article] Modeling of drug (Albumin) release from thermosensitive chitosan hydrogels [texte imprimé] / Roman Zarzycki, Auteur ; Grzegorz Rogacki, Auteur ; Zofia Modrzejewska, Auteur . - 2011 . - pp. 5866-5872. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 9 (Mai 2011) . - pp. 5866-5872 Mots-clés : Modeling Résumé : A theoretical model of drug release in hydrogels was designed taking into account desorption processes on the solid phase surface and diffusion in pores. The model describes kinetics with two constant parameters independent of concentration and time: DAB, the diffusion coefficient of component A in the liquid, and k, the transfer coefficient describing the rate of desorption of component A. The model was verified using experimental data concerning the release of bovine albumin from thermosensitive chitosan gels. The process of albumin release from hydrogels produced from chitosan glutamate can be described by parameters DAB = 2.0 × 10―9 m2/s and k= 1.02 x 10―6 m/s. Calculations based on the model prove that it properly correlates experimental data. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24128713

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