Controlled release of bis(phosphonate) pharmaceuticals from cationic biodegradable polymeric matrices / Konstantinos D. Demadis in Industrial & engineering chemistry research, Vol. 50 N° 9 (Mai 2011)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 50 N° 9 (Mai 2011) . - pp. 5873-5876 Titre : Controlled release of bis(phosphonate) pharmaceuticals from cationic biodegradable polymeric matrices Type de document : texte imprimé Auteurs : Konstantinos D. Demadis, Auteur ; Maria Paspalaki, Auteur ; Joanna Theodorou, Auteur Année de publication : 2011 Article en page(s) : pp. 5873-5876 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Bis(phosphonate) Biodegradable Polymeric Résumé : Herein, the controlled release of etidronic acid (hydroxyethylidene-bis(phosphonic) acid), an important drug for osteoporotic conditions, immobilized onto cationic polymeric matrices, such as polyethyleneimine (PEI) or cationic inulin (CATIN) is reported. Several CATIN- and PEI-etidronate composites have been synthesized at various pH regions and characterized. Tablets with starch as the excipient containing the active ingredient (polymer-etidronate composite) were prepared, and the controlled release of etidronate was studied at aqueous solutions of pH 3 (to mimick the pH of the stomach) for 8 h. All studied composites showed a delayed etidronate release in the first 4 h, compared to the “control” (a tablet containing only starch and etidronic acid, without the polymer). DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie102546g [article] Controlled release of bis(phosphonate) pharmaceuticals from cationic biodegradable polymeric matrices [texte imprimé] / Konstantinos D. Demadis, Auteur ; Maria Paspalaki, Auteur ; Joanna Theodorou, Auteur . - 2011 . - pp. 5873-5876. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 9 (Mai 2011) . - pp. 5873-5876 Mots-clés : Bis(phosphonate) Biodegradable Polymeric Résumé : Herein, the controlled release of etidronic acid (hydroxyethylidene-bis(phosphonic) acid), an important drug for osteoporotic conditions, immobilized onto cationic polymeric matrices, such as polyethyleneimine (PEI) or cationic inulin (CATIN) is reported. Several CATIN- and PEI-etidronate composites have been synthesized at various pH regions and characterized. Tablets with starch as the excipient containing the active ingredient (polymer-etidronate composite) were prepared, and the controlled release of etidronate was studied at aqueous solutions of pH 3 (to mimick the pH of the stomach) for 8 h. All studied composites showed a delayed etidronate release in the first 4 h, compared to the “control” (a tablet containing only starch and etidronic acid, without the polymer). DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie102546g

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