Documents disponibles écrits par cet auteur

Investigation on the spherical crystallization process of cefotaxime sodium / Haitao Zhang in Industrial & engineering chemistry research, Vol. 49 N° 3 (Fevrier 2010)

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 3 (Fevrier 2010) . - pp. 1402–1411 Titre : Investigation on the spherical crystallization process of cefotaxime sodium Type de document : texte imprimé Auteurs : Haitao Zhang, Auteur ; Ying Chen, Auteur ; Jingkang Wang, Auteur Année de publication : 2010 Article en page(s) : pp. 1402–1411 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Investigation  on  the  Spherical  Crystallization  Process  of  Cefotaxime  Sodium Résumé : In order to obtain satisfied spherical agglomerated product and overcome the incomplete removal of the impurity during the traditional spherical agglomerated process, a new strategy incorporating the spherical agglomeration technique and the drowning-out crystallization process, by which the impurities can be efficiently removed, was performed. A triangular phase diagram showing the phase equilibrium of ternary solvent mixtures used in the process of spherical crystallization was constructed and the real-time spherical crystallization process was investigated by means of particle vision measurement and microscopy. The operation conditions, including the chloroform content, temperature of the system, and agitation speed, were also investigated in order to optimize the spherical crystallization process. The results of HPLC and GC indicated that the purity and residual solvents of the experimental agglomerated product can meet the requirements for use. Simultaneously, their bulk density, flowability, and compressibility are far better than the dispersed crystals. The agglomerated particle size was easily controlled by adjusting the chloroform content, temperature of the system, and agitation during spherical crystallization. Especially, the chloroform content is much more important than temperature and agitation in determining agglomerated particle size. ISSN : 0888-5885 [article] Investigation on the spherical crystallization process of cefotaxime sodium [texte imprimé] / Haitao Zhang, Auteur ; Ying Chen, Auteur ; Jingkang Wang, Auteur . - 2010 . - pp. 1402–1411. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 3 (Fevrier 2010) . - pp. 1402–1411 Mots-clés : Investigation  on  the  Spherical  Crystallization  Process  of  Cefotaxime  Sodium Résumé : In order to obtain satisfied spherical agglomerated product and overcome the incomplete removal of the impurity during the traditional spherical agglomerated process, a new strategy incorporating the spherical agglomeration technique and the drowning-out crystallization process, by which the impurities can be efficiently removed, was performed. A triangular phase diagram showing the phase equilibrium of ternary solvent mixtures used in the process of spherical crystallization was constructed and the real-time spherical crystallization process was investigated by means of particle vision measurement and microscopy. The operation conditions, including the chloroform content, temperature of the system, and agitation speed, were also investigated in order to optimize the spherical crystallization process. The results of HPLC and GC indicated that the purity and residual solvents of the experimental agglomerated product can meet the requirements for use. Simultaneously, their bulk density, flowability, and compressibility are far better than the dispersed crystals. The agglomerated particle size was easily controlled by adjusting the chloroform content, temperature of the system, and agitation during spherical crystallization. Especially, the chloroform content is much more important than temperature and agitation in determining agglomerated particle size. ISSN : 0888-5885

Model to simulate the structure of a crystal pillar and optimize the separation efficiency in melt crystallization by fractal theory and technique / Xiaobin Jiang in Industrial & engineering chemistry research, Vol. 50 N° 17 (Septembre 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 17 (Septembre 2011) . - pp. 10229-10245 Titre : Model to simulate the structure of a crystal pillar and optimize the separation efficiency in melt crystallization by fractal theory and technique Type de document : texte imprimé Auteurs : Xiaobin Jiang, Auteur ; Baohong Hou, Auteur ; Jingkang Wang, Auteur Année de publication : 2011 Article en page(s) : pp. 10229-10245 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Fractal  Melt  crystallization  Modeling Résumé : In this paper, an existing fractal porous media model was applied to simulate the structure of the crystal pillar formed in melt crystallization for electronic grade phosphoric acid (EGPA) preparation. The model was modified to meet the crystallization process; the structure parameter of the crystal pillar could be obtained by inspecting the seeping process and measuring the solid-liquid phase equilibrium condition. A characterized factor ϕ with realistic significance was introduced to modify the model, too. The simulation results met the experiment data well. An optimized operation curve was developed to obtain ultrapure EGPA product with higher separation efficiency. An optimized operation was proposed in this paper. Simulating the optimized operation with the model established above, we still obtained a satisfactory result. So the optimized experiment verified the stability and reliability of this model. This model can evaluate the separation effect which is vital to industrial crystal product manufacturing by anticipating the effective porosity of a crystal pillar. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24483667 [article] Model to simulate the structure of a crystal pillar and optimize the separation efficiency in melt crystallization by fractal theory and technique [texte imprimé] / Xiaobin Jiang, Auteur ; Baohong Hou, Auteur ; Jingkang Wang, Auteur . - 2011 . - pp. 10229-10245. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 17 (Septembre 2011) . - pp. 10229-10245 Mots-clés : Fractal  Melt  crystallization  Modeling Résumé : In this paper, an existing fractal porous media model was applied to simulate the structure of the crystal pillar formed in melt crystallization for electronic grade phosphoric acid (EGPA) preparation. The model was modified to meet the crystallization process; the structure parameter of the crystal pillar could be obtained by inspecting the seeping process and measuring the solid-liquid phase equilibrium condition. A characterized factor ϕ with realistic significance was introduced to modify the model, too. The simulation results met the experiment data well. An optimized operation curve was developed to obtain ultrapure EGPA product with higher separation efficiency. An optimized operation was proposed in this paper. Simulating the optimized operation with the model established above, we still obtained a satisfactory result. So the optimized experiment verified the stability and reliability of this model. This model can evaluate the separation effect which is vital to industrial crystal product manufacturing by anticipating the effective porosity of a crystal pillar. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24483667