| Titre : | Practical approach to design and implementation of a control algorithm in an artificial pancreatic beta cell (2009) |
| Auteurs : | Matthew W. Percival, Auteur ; Dassau Eyal, Auteur ; Howard Zisser, Auteur |
| Type de document : | Article : texte imprimé |
| Dans : | Industrial & engineering chemistry research (Vol. 48 N° 13, Juillet 2009) |
| Article en page(s) : | pp. 6059–6067 |
| Note générale : | Chemical engineering |
| Langues : | Anglais |
| Tags : | Artificial pancreatic beta cell Control algorithm Glucose-insulin kinetics Hardware-in-the-loop implementation |
| Résumé : | The rate limiting bottleneck in the development of an artificial pancreatic beta cell is currently the control algorithm used to make insulin dosing decisions. In this paper, a solution for the rapid development of a personalized control algorithm was proposed and the methodology was tested on the pilot scale using a physiological model of glucose−insulin kinetics and a hardware-in-the-loop (HIL) implementation of an artificial pancreatic beta cell. A model-based controller was developed from the identification tests and was augmented with advanced control strategies. The resulting controller improved glycemia from the open-loop case with no hypoglycemic events and a reduction in time spent hyperglycemic. Robustness issues were addressed with a 50% mismatch in insulin sensitivity from model to plant. The HIL platform provided insight into the effects of sensor drift and practicalities of continuous insulin delivery based on glucose sensor feedback. |
| En ligne : | http://pubs.acs.org/doi/abs/10.1021/ie801432u |
