l - glutamic acid polymorph control using amino acid additives / Yuxin Mo in Industrial & engineering chemistry research, Vol. 50 N° 18 (Septembre 2011)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 50 N° 18 (Septembre 2011) . - pp. 10385–10392 Titre : l - glutamic acid polymorph control using amino acid additives Type de document : texte imprimé Auteurs : Yuxin Mo, Auteur ; Leping Dang, Auteur ; Hongyuan Wei, Auteur Année de publication : 2011 Article en page(s) : pp. 10385–10392 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Additive Résumé : Additive is an effective factor in controlling crystallization of polymorph. L-Tryptophan, L-leucine, L-threonine, L-histidine, L-alanine, and L-valine, as additives during L-glutamic acid crystallization, were investigated for probing their effects on the polymorphic transformation. L-Tryptophan was then chosen as a representative case to evaluate the effect of addition concentration on the morphology, nucleation, and polymorphic transformation rate of L-glutamic acid. It is shown that all these additives have a certain influence on the polymorphic transformation and the presence of a bulky side chain (phenyl) in L-tryptophan and L-histidine is identified as an essential feature in achieving stabilization of the α-polymorph. When the concentration of L-tryptophan reaches above 0.008 M, the elongation of crystals occur. Increasing L-tryptophan concentration, the transformation time and nucleation rate of L-glutamic acid are retarded. The inclusion behavior of additive molecules in L-Glu crystals was investigated, and the results show that the effect of additive molecule on the polymorphic transformation may be through incorporating into crystal structures by adsorption. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24523859 [article] l - glutamic acid polymorph control using amino acid additives [texte imprimé] / Yuxin Mo, Auteur ; Leping Dang, Auteur ; Hongyuan Wei, Auteur . - 2011 . - pp. 10385–10392. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 18 (Septembre 2011) . - pp. 10385–10392 Mots-clés : Additive Résumé : Additive is an effective factor in controlling crystallization of polymorph. L-Tryptophan, L-leucine, L-threonine, L-histidine, L-alanine, and L-valine, as additives during L-glutamic acid crystallization, were investigated for probing their effects on the polymorphic transformation. L-Tryptophan was then chosen as a representative case to evaluate the effect of addition concentration on the morphology, nucleation, and polymorphic transformation rate of L-glutamic acid. It is shown that all these additives have a certain influence on the polymorphic transformation and the presence of a bulky side chain (phenyl) in L-tryptophan and L-histidine is identified as an essential feature in achieving stabilization of the α-polymorph. When the concentration of L-tryptophan reaches above 0.008 M, the elongation of crystals occur. Increasing L-tryptophan concentration, the transformation time and nucleation rate of L-glutamic acid are retarded. The inclusion behavior of additive molecules in L-Glu crystals was investigated, and the results show that the effect of additive molecule on the polymorphic transformation may be through incorporating into crystal structures by adsorption. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24523859

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