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Blend microspheres of poly(3-hydroxybutyrate) and cellulose acetate phthalate for colon delivery of 5-fluorouracil / Kiran Chaturvedi in Industrial & engineering chemistry research, Vol. 50 N° 18 (Septembre 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 18 (Septembre 2011) . - pp. 10414-10423 Titre : Blend microspheres of poly(3-hydroxybutyrate) and cellulose acetate phthalate for colon delivery of 5-fluorouracil Type de document : texte imprimé Auteurs : Kiran Chaturvedi, Auteur ; Anandrao R. Kulkarni, Auteur ; Tejraj M. Aminabhavi, Auteur Année de publication : 2011 Article en page(s) : pp. 10414-10423 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Microsphere Résumé : Blend microspheres of poly(3-hydroxybutyrate) (PHB) and cellulose acetate phthalate (CAP) have been prepared in compositions of 2:1, 1:1, and 1:3 (w/w) by the solvent evaporation technique. These pH-sensitive polymers were utilized to investigate the colon delivery of 5-fluorouracil (5-FU), an anticancer drug. The surface morphology of the microspheres was studied by scanning electron microscopy (SEM), which confirmed their spherical nature with sizes ranging from 29 to 67 μm, as well as pore structures before and after the dissolution experiments. Fourier transform infrared (FTIR) spectroscopy was used to confirm the polymer blend compatibility and to confirm the absence of drug–polymer interactions. Differential scanning calorimetry (DSC) was employed to study the crystalline nature and molecular-level dispersion of 5-FU in the matrixes after encapsulation. In vitro release experiments were performed at 37 °C in simulated buffer medium of the stomach (pH 1.2) for 2 h, followed by simulated intestinal medium (pH 7.4). It was found that the release of 5-FU from blend microspheres followed pH-dependent release as compared to that of plain PHB microspheres. From the in vitro release studies, it was found that blend microspheres are more efficient at delivering 5-FU to the colon than plain PHB microspheres. Furthermore, release data were fitted to empirical equations to understand the nature of the drug release profiles. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24523863 [article] Blend microspheres of poly(3-hydroxybutyrate) and cellulose acetate phthalate for colon delivery of 5-fluorouracil [texte imprimé] / Kiran Chaturvedi, Auteur ; Anandrao R. Kulkarni, Auteur ; Tejraj M. Aminabhavi, Auteur . - 2011 . - pp. 10414-10423. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 18 (Septembre 2011) . - pp. 10414-10423 Mots-clés : Microsphere Résumé : Blend microspheres of poly(3-hydroxybutyrate) (PHB) and cellulose acetate phthalate (CAP) have been prepared in compositions of 2:1, 1:1, and 1:3 (w/w) by the solvent evaporation technique. These pH-sensitive polymers were utilized to investigate the colon delivery of 5-fluorouracil (5-FU), an anticancer drug. The surface morphology of the microspheres was studied by scanning electron microscopy (SEM), which confirmed their spherical nature with sizes ranging from 29 to 67 μm, as well as pore structures before and after the dissolution experiments. Fourier transform infrared (FTIR) spectroscopy was used to confirm the polymer blend compatibility and to confirm the absence of drug–polymer interactions. Differential scanning calorimetry (DSC) was employed to study the crystalline nature and molecular-level dispersion of 5-FU in the matrixes after encapsulation. In vitro release experiments were performed at 37 °C in simulated buffer medium of the stomach (pH 1.2) for 2 h, followed by simulated intestinal medium (pH 7.4). It was found that the release of 5-FU from blend microspheres followed pH-dependent release as compared to that of plain PHB microspheres. From the in vitro release studies, it was found that blend microspheres are more efficient at delivering 5-FU to the colon than plain PHB microspheres. Furthermore, release data were fitted to empirical equations to understand the nature of the drug release profiles. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24523863