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Scale-up of a pharmaceutical roller compaction process using a joint-Y partial least squares model / Zheng Liu in Industrial & engineering chemistry research, Vol. 50 N° 18 (Septembre 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 18 (Septembre 2011) . - pp. 10696-10706 Titre : Scale-up of a pharmaceutical roller compaction process using a joint-Y partial least squares model Type de document : texte imprimé Auteurs : Zheng Liu, Auteur ; Mark-John Bruwer, Auteur ; John F. MacGregor, Auteur Année de publication : 2011 Article en page(s) : pp. 10696-10706 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Modeling  Partial  least  squares  Compaction  Scale  effect  Extrapolation Résumé : Garda-Munoz et al. [Garcia-Munoz, S.; Kourti, T.; MacGregor, J. F. Chemom. Intell. Lab. Syst. 2005, 79, 101―114] proposed a new latent variable regression methodology, joint-Y partial least squares (JYPLS), for product transfer between plants. In this paper, this method is used for product scale-up from a type of laboratory-scale roller compactor, a Fitzpatrick IR220, to a type of full-scale roller compactor, a Fitzpatrick IR520, in the pharmaceutical industry. AJYPLS model is first built with the data set collected from historical experiments on these two types of compactors. The JYPLS model relates API mass fraction, excipient mass factions, and roller compaction process measurements to ribbon properties. A constrained optimization is then formulated to invert the JYPLS model to find the key process settings of the Fitzpatrick IR520 to make the same quality of ribbon using the same raw materials formulation as the ribbon that had been produced on the Fitzpatrick IR220. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24523887 [article] Scale-up of a pharmaceutical roller compaction process using a joint-Y partial least squares model [texte imprimé] / Zheng Liu, Auteur ; Mark-John Bruwer, Auteur ; John F. MacGregor, Auteur . - 2011 . - pp. 10696-10706. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 18 (Septembre 2011) . - pp. 10696-10706 Mots-clés : Modeling  Partial  least  squares  Compaction  Scale  effect  Extrapolation Résumé : Garda-Munoz et al. [Garcia-Munoz, S.; Kourti, T.; MacGregor, J. F. Chemom. Intell. Lab. Syst. 2005, 79, 101―114] proposed a new latent variable regression methodology, joint-Y partial least squares (JYPLS), for product transfer between plants. In this paper, this method is used for product scale-up from a type of laboratory-scale roller compactor, a Fitzpatrick IR220, to a type of full-scale roller compactor, a Fitzpatrick IR520, in the pharmaceutical industry. AJYPLS model is first built with the data set collected from historical experiments on these two types of compactors. The JYPLS model relates API mass fraction, excipient mass factions, and roller compaction process measurements to ribbon properties. A constrained optimization is then formulated to invert the JYPLS model to find the key process settings of the Fitzpatrick IR520 to make the same quality of ribbon using the same raw materials formulation as the ribbon that had been produced on the Fitzpatrick IR220. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24523887