| Titre : | Nanostructured PLLA-hydroxyapatite scaffolds produced by a supercritical assisted technique (2009) |
| Auteurs : | Ernesto Reverchon, Auteur ; Paola Pisanti, Auteur ; Stefano Cardea, Auteur |
| Type de document : | Article : texte imprimé |
| Dans : | Industrial & engineering chemistry research (Vol. 48 N° 11, Juin 2009) |
| Article en page(s) : | pp. 5310–5316 |
| Note générale : | Chemical engineering |
| Langues : | Anglais |
| Tags : | Bone scaffolds Nanostructural properties Supercritical fluid assisted technique Hydroxyapatite nanoparticles |
| Résumé : | Temporary bone scaffolds can surrogate the extracellular matrix to favor the regeneration of tissues and organs. It is very difficult to obtain the coexistence of the macro-, micro-, and nanostructural properties necessary to mimic the organization of the human bone. To obtain all of these characteristics, we tested a supercritical fluid assisted technique for the formation of PLLA/ceramic scaffolds using hydroxyapatite (HA) nanoparticles loaded at up to 50% by weight of the polymer to improve the biomimethism and the mechanical properties of the scaffolds. We produced poly(l-lactic acid) scaffolds in relatively short time (<30 h), with a porosity higher than 90% and with a high interconnectivity. An internal structure formed by very long nanofibers of 200−400 nm diameter and prefixed macroscopic shape and size was also obtained. A maximum compressive modulus of 123 kPa was obtained, and the solvent residue was lower than 5 ppm. |
| En ligne : | http://pubs.acs.org/doi/abs/10.1021/ie8018752 |
