Documents disponibles écrits par cet auteur

Investigation on the uniformity and stability of sunflower oil/water emulsions prepared by a shirasu porous glass membrane / Yueling Zhang in Industrial & engineering chemistry research, Vol. 47 N°17 (Septembre 2008) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 47 N°17 (Septembre 2008) . - p. 6412–6417 Titre : Investigation on the uniformity and stability of sunflower oil/water emulsions prepared by a shirasu porous glass membrane Type de document : texte imprimé Auteurs : Yueling Zhang, Auteur ; Guoping Lian, Auteur ; Shiping Zhu, Auteur Année de publication : 2008 Article en page(s) : p. 6412–6417 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : SPG  membrane  emulsification  Sunflower  oil  emulsions Résumé : Shirasu porous glass (SPG) membrane emulsification has many advantages over traditional emulsification methods of stirring, ultrasoubd, and homogenization. The main advantages are much improved uniform size distribution of the droplets and lower mechanical shear stress. This paper examines the uniformity and stability of sunflower oil emulsions prepared by SPG membrane. The effects of emulsifiers on the uniformity and stability of emulsions were investigated. Results showed that emulsions stabilized by Tween 20 are generally more uniform and stable compared to those stabilized by Tween 60. Emulsions prepared by membrane emulsification showed excellent uniformity and stability with no droplet size change after 6-months storage, while those prepared by the homogenizer have a much broad size distribution and are unstable after 7 days of storage with significant further broadening of the droplet size distribution by coalescence and Oswald ripening. Uniform-sized sunflower O/W emulsions prepared by the SPG membrane also have good thermal stability when subjected to either freezing or heating. The mechanical stability of sunflower O/W emulsions prepared by the SPG membrane can be further improved by adding thickeners to the aqueous phase. Therefore, SPG membrane emulsification is a promising method for preparing uniform and stable emulsions, which will have good potential applications in the food industry, in terms of improving shelf life and product quality. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie8002232 [article] Investigation on the uniformity and stability of sunflower oil/water emulsions prepared by a shirasu porous glass membrane [texte imprimé] / Yueling Zhang, Auteur ; Guoping Lian, Auteur ; Shiping Zhu, Auteur . - 2008 . - p. 6412–6417. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 47 N°17 (Septembre 2008) . - p. 6412–6417 Mots-clés : SPG  membrane  emulsification  Sunflower  oil  emulsions Résumé : Shirasu porous glass (SPG) membrane emulsification has many advantages over traditional emulsification methods of stirring, ultrasoubd, and homogenization. The main advantages are much improved uniform size distribution of the droplets and lower mechanical shear stress. This paper examines the uniformity and stability of sunflower oil emulsions prepared by SPG membrane. The effects of emulsifiers on the uniformity and stability of emulsions were investigated. Results showed that emulsions stabilized by Tween 20 are generally more uniform and stable compared to those stabilized by Tween 60. Emulsions prepared by membrane emulsification showed excellent uniformity and stability with no droplet size change after 6-months storage, while those prepared by the homogenizer have a much broad size distribution and are unstable after 7 days of storage with significant further broadening of the droplet size distribution by coalescence and Oswald ripening. Uniform-sized sunflower O/W emulsions prepared by the SPG membrane also have good thermal stability when subjected to either freezing or heating. The mechanical stability of sunflower O/W emulsions prepared by the SPG membrane can be further improved by adding thickeners to the aqueous phase. Therefore, SPG membrane emulsification is a promising method for preparing uniform and stable emulsions, which will have good potential applications in the food industry, in terms of improving shelf life and product quality. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie8002232

Preparation of ca-alginate microparticles and its application for phenylketonuria oral therapy / Yueling Zhang in Industrial & engineering chemistry research, Vol. 50 N° 7 (Avril 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 7 (Avril 2011) . - pp. 4106–4112 Titre : Preparation of ca-alginate microparticles and its application for phenylketonuria oral therapy Type de document : texte imprimé Auteurs : Yueling Zhang, Auteur ; Xingyuan Jia, Auteur ; Lianyan Wang, Auteur Année de publication : 2011 Article en page(s) : pp. 4106–4112 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Microparticles Résumé : Lactococcus lactis-expressing phenylalanine ammonia-lyase (LLEP) has been used to treat one of the classic genetic diseases, phenylketonuria (PKU). However, the action of stomach fluid and short residence time of LLEP at the site of absorption become the “neck” for the oral administration of LLEP. To solve these problems, pH-sensitive Ca-alginate microparticles designed as an oral administration carrier were prepared by a spray-solidification method in this study. The spray conditions influenced the size of the Ca-alginate microparticles; thus, conditions were optimized to obtain microparticles with smaller particle size for oral administration to mice. Subsequently, LLEP was encapsulated into Ca-alginate microparticles and the activity retention of LLEP released from the microparticles was examined after the microparticles passed through simulated gastric fluid. The results showed that LLEP could be well protected against simulated gastric fluid and that the final activity retention was up to 92.9%. The effects of alginate concentration on the release profile in vitro and the encapsulation efficiency (EE) were studied, and the results revealed that the microparticles possessed the highest EE and a reasonable release rate when the alginate concentration was 1.0 wt %. This alginate concentration, combined with optimized spray conditions, was used to prepare LLEP-encapsulated microparticles, and they were administered orally to mice with phenylketonuria (PKU). Compared with the groups given blank microparticles and nonencapsulated LLEP, the increase of the blood phenylalanine (Phe) level was significantly slowed after a 7 day treatment with LLEP-encapsulated microparticles. Consequently, the Ca-alginate microparticle developed by the spray-solidification method is a promising carrier of LLEP for oral administration. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie101973h [article] Preparation of ca-alginate microparticles and its application for phenylketonuria oral therapy [texte imprimé] / Yueling Zhang, Auteur ; Xingyuan Jia, Auteur ; Lianyan Wang, Auteur . - 2011 . - pp. 4106–4112. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 7 (Avril 2011) . - pp. 4106–4112 Mots-clés : Microparticles Résumé : Lactococcus lactis-expressing phenylalanine ammonia-lyase (LLEP) has been used to treat one of the classic genetic diseases, phenylketonuria (PKU). However, the action of stomach fluid and short residence time of LLEP at the site of absorption become the “neck” for the oral administration of LLEP. To solve these problems, pH-sensitive Ca-alginate microparticles designed as an oral administration carrier were prepared by a spray-solidification method in this study. The spray conditions influenced the size of the Ca-alginate microparticles; thus, conditions were optimized to obtain microparticles with smaller particle size for oral administration to mice. Subsequently, LLEP was encapsulated into Ca-alginate microparticles and the activity retention of LLEP released from the microparticles was examined after the microparticles passed through simulated gastric fluid. The results showed that LLEP could be well protected against simulated gastric fluid and that the final activity retention was up to 92.9%. The effects of alginate concentration on the release profile in vitro and the encapsulation efficiency (EE) were studied, and the results revealed that the microparticles possessed the highest EE and a reasonable release rate when the alginate concentration was 1.0 wt %. This alginate concentration, combined with optimized spray conditions, was used to prepare LLEP-encapsulated microparticles, and they were administered orally to mice with phenylketonuria (PKU). Compared with the groups given blank microparticles and nonencapsulated LLEP, the increase of the blood phenylalanine (Phe) level was significantly slowed after a 7 day treatment with LLEP-encapsulated microparticles. Consequently, the Ca-alginate microparticle developed by the spray-solidification method is a promising carrier of LLEP for oral administration. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie101973h