Enhancement of particle collection efficiency in electrohydrodynamic atomization process for pharmaceutical particle fabrication / Alireza Rezvanpour in Industrial & engineering chemistry research, Vol. 49 N° 24 (Décembre 2010)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 49 N° 24 (Décembre 2010) . - pp. 12620-12631 Titre : Enhancement of particle collection efficiency in electrohydrodynamic atomization process for pharmaceutical particle fabrication Type de document : texte imprimé Auteurs : Alireza Rezvanpour, Auteur ; Amalina B. E. Attia, Auteur ; Chi-Hwa Wang, Auteur Année de publication : 2011 Article en page(s) : pp. 12620-12631 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Electrohydrodynamics Particle collection Résumé : In the present work, Electrohydrodynamic Atomization was employed to produce biodegradable polymeri microparticles in a new generation of shuttle glass chamber. The effects of different parameters including solution flow rate, nitrogen flow rate, nozzle, and ring voltage on the particle collection efficiency and residua amount of organic solvent in collected particles were investigated systematically. The Taguchi (a combine< experimental and statistical) method was used to obtain the optimal collection conditions for the particle collection efficiency. It was found that the important factors affecting particle collection efficiency were given in the following order-solution flow rate, nitrogen flow rate, ring, and nozzle voltage. It was also found tha voltage difference between nozzle and ring can significantly affect the particle collection efficiency. Duration of the process, polymer material, and electrical conductivity of the solution were the other factors that affected particle collection efficiency. It was found that solution flow rate and nozzle voltage can considerably affec the size of fabricated particles. Gas Chromatography/Mass Spectrometry was used to determine the residua content of Dichloromethane (DCM) in the collected particles. For all 16 trials, the residual DCM content o the particles fabricated using the EHDA method was well within the limit of safety standards (600 ppm) a the end of process without engaging any additional freeze-drying process. In summary, high collection efficiency and minimum residual solvent in collected particles can be achieved by adjusting the operating parameters and geometrical characteristics of the system. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=23692018 [article] Enhancement of particle collection efficiency in electrohydrodynamic atomization process for pharmaceutical particle fabrication [texte imprimé] / Alireza Rezvanpour, Auteur ; Amalina B. E. Attia, Auteur ; Chi-Hwa Wang, Auteur . - 2011 . - pp. 12620-12631. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 24 (Décembre 2010) . - pp. 12620-12631 Mots-clés : Electrohydrodynamics Particle collection Résumé : In the present work, Electrohydrodynamic Atomization was employed to produce biodegradable polymeri microparticles in a new generation of shuttle glass chamber. The effects of different parameters including solution flow rate, nitrogen flow rate, nozzle, and ring voltage on the particle collection efficiency and residua amount of organic solvent in collected particles were investigated systematically. The Taguchi (a combine< experimental and statistical) method was used to obtain the optimal collection conditions for the particle collection efficiency. It was found that the important factors affecting particle collection efficiency were given in the following order-solution flow rate, nitrogen flow rate, ring, and nozzle voltage. It was also found tha voltage difference between nozzle and ring can significantly affect the particle collection efficiency. Duration of the process, polymer material, and electrical conductivity of the solution were the other factors that affected particle collection efficiency. It was found that solution flow rate and nozzle voltage can considerably affec the size of fabricated particles. Gas Chromatography/Mass Spectrometry was used to determine the residua content of Dichloromethane (DCM) in the collected particles. For all 16 trials, the residual DCM content o the particles fabricated using the EHDA method was well within the limit of safety standards (600 ppm) a the end of process without engaging any additional freeze-drying process. In summary, high collection efficiency and minimum residual solvent in collected particles can be achieved by adjusting the operating parameters and geometrical characteristics of the system. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=23692018

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