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A heuristic - embedded scheduling system for a pharmaceutical intermediates manufacturing plant / Jiyong Kim in Industrial & engineering chemistry research, Vol. 49 N° 24 (Décembre 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 24 (Décembre 2010) . - pp. 12646-12653 Titre : A heuristic - embedded scheduling system for a pharmaceutical intermediates manufacturing plant Type de document : texte imprimé Auteurs : Jiyong Kim, Auteur ; Junghwan Kim, Auteur ; Taeyeong Lee, Auteur Année de publication : 2011 Article en page(s) : pp. 12646-12653 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Manufacturing  Scheduling Résumé : This paper proposes a new mathematical model for a real pharmaceutical intermediates manufacturing (PIM plant. To consider the general characteristics of the scheduling problems experienced at PIM plants, the propose model employed a strategy to address a mixed-integer linear programming (MILP) formulation. Two heuristi techniques—preclassification of equipment and sequential two-stage optimization-were then proposed, to relax the complexities of scheduling problems that are due to practical constraints. The objective function the proposed model is to minimize the total operation time (makespan) that is subject to the mass balance constraints and process boundary conditions. On the basis of the proposed models and heuristics, new package software is developed for an application to real PIM plants. To show the features and capabilities of th proposed scheduling system, four real examples were examined. The results reveal that the techniques ar helpful for obtaining both higher accuracy of optimized solutions and higher computational performance. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=23692021 [article] A heuristic - embedded scheduling system for a pharmaceutical intermediates manufacturing plant [texte imprimé] / Jiyong Kim, Auteur ; Junghwan Kim, Auteur ; Taeyeong Lee, Auteur . - 2011 . - pp. 12646-12653. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 24 (Décembre 2010) . - pp. 12646-12653 Mots-clés : Manufacturing  Scheduling Résumé : This paper proposes a new mathematical model for a real pharmaceutical intermediates manufacturing (PIM plant. To consider the general characteristics of the scheduling problems experienced at PIM plants, the propose model employed a strategy to address a mixed-integer linear programming (MILP) formulation. Two heuristi techniques—preclassification of equipment and sequential two-stage optimization-were then proposed, to relax the complexities of scheduling problems that are due to practical constraints. The objective function the proposed model is to minimize the total operation time (makespan) that is subject to the mass balance constraints and process boundary conditions. On the basis of the proposed models and heuristics, new package software is developed for an application to real PIM plants. To show the features and capabilities of th proposed scheduling system, four real examples were examined. The results reveal that the techniques ar helpful for obtaining both higher accuracy of optimized solutions and higher computational performance. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=23692021