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Analysis of dissolved - gas atomization / Giuseppe Caputo in Industrial & engineering chemistry research, Vol. 49 N° 19 (Octobre 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 19 (Octobre 2010) . - pp. 9454–9461 Titre : Analysis of dissolved - gas atomization : Supercritical CO2 dissolved in water Type de document : texte imprimé Auteurs : Giuseppe Caputo, Auteur ; Renata Adami, Auteur ; Ernesto Reverchon, Auteur Année de publication : 2010 Article en page(s) : pp. 9454–9461 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Gas  Atomization  Dissolved Résumé : Supercritical dissolved-gas atomization is an atomization process in which carbon dioxide at temperature and pressure above its critical point is used as the atomizing gas. The spray characteristics in terms of droplets size and distribution have been experimentally studied using a laser diffraction method based on a Malvern apparatus. The main parameter that influences the droplets size is the gas-to-liquid mass ratio (GLR); the injection pressure in the range of 7.4−13 MPa has a minor effect. Upon variation of the GLR from 0.5 to 3, the droplet mean diameter changes from about 8.0 to 2.0 μm; very narrow droplet size distributions are also produced. From the point of view of the atomization mechanism, the mean droplet diameter is mainly influenced by the sudden release of the gas dissolved in the liquid. The overall analysis of the experimental data confirms that dissolved-gas atomization allows for the formation of micrometric droplets that can produce precipitates with controlled sizes and distributions that are useful in several fine-particles production processes. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie100925w [article] Analysis of dissolved - gas atomization : Supercritical CO2 dissolved in water [texte imprimé] / Giuseppe Caputo, Auteur ; Renata Adami, Auteur ; Ernesto Reverchon, Auteur . - 2010 . - pp. 9454–9461. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 19 (Octobre 2010) . - pp. 9454–9461 Mots-clés : Gas  Atomization  Dissolved Résumé : Supercritical dissolved-gas atomization is an atomization process in which carbon dioxide at temperature and pressure above its critical point is used as the atomizing gas. The spray characteristics in terms of droplets size and distribution have been experimentally studied using a laser diffraction method based on a Malvern apparatus. The main parameter that influences the droplets size is the gas-to-liquid mass ratio (GLR); the injection pressure in the range of 7.4−13 MPa has a minor effect. Upon variation of the GLR from 0.5 to 3, the droplet mean diameter changes from about 8.0 to 2.0 μm; very narrow droplet size distributions are also produced. From the point of view of the atomization mechanism, the mean droplet diameter is mainly influenced by the sudden release of the gas dissolved in the liquid. The overall analysis of the experimental data confirms that dissolved-gas atomization allows for the formation of micrometric droplets that can produce precipitates with controlled sizes and distributions that are useful in several fine-particles production processes. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie100925w

Beclomethasone microparticles for wet inhalation, produced by supercritical assisted atomization / Ernesto Reverchon in Industrial & engineering chemistry research, Vol. 49 N° 24 (Décembre 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 24 (Décembre 2010) . - pp. 12747-12755 Titre : Beclomethasone microparticles for wet inhalation, produced by supercritical assisted atomization Type de document : texte imprimé Auteurs : Ernesto Reverchon, Auteur ; Renata Adami, Auteur ; Mariarosa Scognamiglio, Auteur Année de publication : 2011 Article en page(s) : pp. 12747-12755 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Supercritical  state  Microparticle Résumé : Supercritical assisted atomization (SAA) was used to produce micronized particles of beclomethasone dipropionate (BDP) to be used for inhalation therapy. Methanol, acetone, acetone + water 9% v/v, and methanol + water 4% v/v were tested as liquid solvents to explore their influence on particle size and crystalline structure of the precipitated powder. Particles with narrow size distributions (PSD) were obtained by changing the SAA process operating conditions. In particular, using acetone + water 9% v/v with a BDP concentration of 90 mg/mL, crystalline particles ranging between 0.2 and 4.7 μm were produced and 70% by volume of these particles ranged between 1 and 3 μm. PSD stability analysis in a wet formulation showed that BDP powder obtained by SAA does not modify over a long period of time. The results obtained on the laboratory scale plant were successfully reproduced on a pilot plant and a further refinement of the operating conditions was performed. About 30 g of BDP microparticles were produced per batch and a recovery of about 93 wt % of the micronized powder with respect to the injected quantity was obtained. The largest volumetric fraction of BDP particles falling in the range 1-3 μm was 83% on the pilot scale. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=23692032 [article] Beclomethasone microparticles for wet inhalation, produced by supercritical assisted atomization [texte imprimé] / Ernesto Reverchon, Auteur ; Renata Adami, Auteur ; Mariarosa Scognamiglio, Auteur . - 2011 . - pp. 12747-12755. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 24 (Décembre 2010) . - pp. 12747-12755 Mots-clés : Supercritical  state  Microparticle Résumé : Supercritical assisted atomization (SAA) was used to produce micronized particles of beclomethasone dipropionate (BDP) to be used for inhalation therapy. Methanol, acetone, acetone + water 9% v/v, and methanol + water 4% v/v were tested as liquid solvents to explore their influence on particle size and crystalline structure of the precipitated powder. Particles with narrow size distributions (PSD) were obtained by changing the SAA process operating conditions. In particular, using acetone + water 9% v/v with a BDP concentration of 90 mg/mL, crystalline particles ranging between 0.2 and 4.7 μm were produced and 70% by volume of these particles ranged between 1 and 3 μm. PSD stability analysis in a wet formulation showed that BDP powder obtained by SAA does not modify over a long period of time. The results obtained on the laboratory scale plant were successfully reproduced on a pilot plant and a further refinement of the operating conditions was performed. About 30 g of BDP microparticles were produced per batch and a recovery of about 93 wt % of the micronized powder with respect to the injected quantity was obtained. The largest volumetric fraction of BDP particles falling in the range 1-3 μm was 83% on the pilot scale. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=23692032

Use of supercritical CO2 and N2 as dissolved gases for the atomization of ethanol and water / Giuseppe Caputo in Industrial & engineering chemistry research, Vol. 51 N° 36 (Septembre 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 36 (Septembre 2012) . - pp. 11803-11808 Titre : Use of supercritical CO2 and N2 as dissolved gases for the atomization of ethanol and water Type de document : texte imprimé Auteurs : Giuseppe Caputo, Auteur ; Sara Liparoti, Auteur ; Renata Adami, Auteur Année de publication : 2012 Article en page(s) : pp. 11803-11808 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Supercritical  state  Carbon  dioxide Résumé : Supercritical dissolved gas atomization (SDGA) is an atomization process in which a gas at temperatures and pressures above the critical point is used as the atomizing medium. The concept of SDGA has been applied mainly using CO2 as atomizing gas in various processes developed for the production of fine particles of pharmaceuticals, polymers, and chemical products and for the atomization of fuels. In this work, SDGA, using ethanol and water as the liquids to be atomized, has been experimentally studied. The spray characteristics, in terms of droplet size and distribution, have been investigated using a laser diffraction analyzer. Ethanol has been chosen due to the large miscibility with CO2 and for its wide use as a solvent in particle formation processes. The use of N2 as an atomizing gas has been also studied. Very narrow droplet size distributions were produced down to 2.5 μm. The properties of the liquid to be atomized (water or ethanol) showed a negligible effect on droplet size. The main parameter that influences droplet size is the gas to liquid mass ratio. Nitrogen has a better potentiality as an atomizing gas with respect to carbon dioxide. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26350347 [article] Use of supercritical CO2 and N2 as dissolved gases for the atomization of ethanol and water [texte imprimé] / Giuseppe Caputo, Auteur ; Sara Liparoti, Auteur ; Renata Adami, Auteur . - 2012 . - pp. 11803-11808. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 36 (Septembre 2012) . - pp. 11803-11808 Mots-clés : Supercritical  state  Carbon  dioxide Résumé : Supercritical dissolved gas atomization (SDGA) is an atomization process in which a gas at temperatures and pressures above the critical point is used as the atomizing medium. The concept of SDGA has been applied mainly using CO2 as atomizing gas in various processes developed for the production of fine particles of pharmaceuticals, polymers, and chemical products and for the atomization of fuels. In this work, SDGA, using ethanol and water as the liquids to be atomized, has been experimentally studied. The spray characteristics, in terms of droplet size and distribution, have been investigated using a laser diffraction analyzer. Ethanol has been chosen due to the large miscibility with CO2 and for its wide use as a solvent in particle formation processes. The use of N2 as an atomizing gas has been also studied. Very narrow droplet size distributions were produced down to 2.5 μm. The properties of the liquid to be atomized (water or ethanol) showed a negligible effect on droplet size. The main parameter that influences droplet size is the gas to liquid mass ratio. Nitrogen has a better potentiality as an atomizing gas with respect to carbon dioxide. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26350347