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Beclomethasone microparticles for wet inhalation, produced by supercritical assisted atomization / Ernesto Reverchon in Industrial & engineering chemistry research, Vol. 49 N° 24 (Décembre 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 24 (Décembre 2010) . - pp. 12747-12755 Titre : Beclomethasone microparticles for wet inhalation, produced by supercritical assisted atomization Type de document : texte imprimé Auteurs : Ernesto Reverchon, Auteur ; Renata Adami, Auteur ; Mariarosa Scognamiglio, Auteur Année de publication : 2011 Article en page(s) : pp. 12747-12755 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Supercritical  state  Microparticle Résumé : Supercritical assisted atomization (SAA) was used to produce micronized particles of beclomethasone dipropionate (BDP) to be used for inhalation therapy. Methanol, acetone, acetone + water 9% v/v, and methanol + water 4% v/v were tested as liquid solvents to explore their influence on particle size and crystalline structure of the precipitated powder. Particles with narrow size distributions (PSD) were obtained by changing the SAA process operating conditions. In particular, using acetone + water 9% v/v with a BDP concentration of 90 mg/mL, crystalline particles ranging between 0.2 and 4.7 μm were produced and 70% by volume of these particles ranged between 1 and 3 μm. PSD stability analysis in a wet formulation showed that BDP powder obtained by SAA does not modify over a long period of time. The results obtained on the laboratory scale plant were successfully reproduced on a pilot plant and a further refinement of the operating conditions was performed. About 30 g of BDP microparticles were produced per batch and a recovery of about 93 wt % of the micronized powder with respect to the injected quantity was obtained. The largest volumetric fraction of BDP particles falling in the range 1-3 μm was 83% on the pilot scale. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=23692032 [article] Beclomethasone microparticles for wet inhalation, produced by supercritical assisted atomization [texte imprimé] / Ernesto Reverchon, Auteur ; Renata Adami, Auteur ; Mariarosa Scognamiglio, Auteur . - 2011 . - pp. 12747-12755. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 24 (Décembre 2010) . - pp. 12747-12755 Mots-clés : Supercritical  state  Microparticle Résumé : Supercritical assisted atomization (SAA) was used to produce micronized particles of beclomethasone dipropionate (BDP) to be used for inhalation therapy. Methanol, acetone, acetone + water 9% v/v, and methanol + water 4% v/v were tested as liquid solvents to explore their influence on particle size and crystalline structure of the precipitated powder. Particles with narrow size distributions (PSD) were obtained by changing the SAA process operating conditions. In particular, using acetone + water 9% v/v with a BDP concentration of 90 mg/mL, crystalline particles ranging between 0.2 and 4.7 μm were produced and 70% by volume of these particles ranged between 1 and 3 μm. PSD stability analysis in a wet formulation showed that BDP powder obtained by SAA does not modify over a long period of time. The results obtained on the laboratory scale plant were successfully reproduced on a pilot plant and a further refinement of the operating conditions was performed. About 30 g of BDP microparticles were produced per batch and a recovery of about 93 wt % of the micronized powder with respect to the injected quantity was obtained. The largest volumetric fraction of BDP particles falling in the range 1-3 μm was 83% on the pilot scale. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=23692032