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Development of electrochemical method for the determination of chlorzoxazone drug and its analytical applications to pharmaceutical dosage form and human biological fluids / Jyothi C. Abbar in Industrial & engineering chemistry research, Vol. 51 N° 1 (Janvier 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 1 (Janvier 2012) . - pp. 111-118 Titre : Development of electrochemical method for the determination of chlorzoxazone drug and its analytical applications to pharmaceutical dosage form and human biological fluids Type de document : texte imprimé Auteurs : Jyothi C. Abbar, Auteur ; Sharanappa T. Nandibewoor, Auteur Année de publication : 2012 Article en page(s) : pp. 111-118 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Human  Electrochemical  method Résumé : The electrochemical behavior of chlorzoxazone drug at glassy carbon electrode has been investigated for the first time using cyclic and square wave voltammetric techniques. The dependence of the current on pH, concentration, and scan rate was investigated to optimize the experimental conditions for determination ofchlorzoxazone. The anodic peak was characterized and the process was diffusion-controlled. The number of electrons transferred in the oxidation process was calculated and a plausible oxidation mechanism was proposed. In the range of 8.0 x 10―7 to 1.0 x 10―5 M, the current measured by square wave voltammetry presents a good linear property as a function of the concentration of chlorzoxazone with a detection limit of 4.41 x 10―8 M with good selectivity and sensitivity. The proposed method was successfully applied to chlorzoxazone determination under physiological condition in pharmaceutical samples and for the detection of chlorzoxazone in human biological fluids. This method can be employed in clinical analysis, quality control, and routine determination of drugs in pharmaceutical formulations. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=25476452 [article] Development of electrochemical method for the determination of chlorzoxazone drug and its analytical applications to pharmaceutical dosage form and human biological fluids [texte imprimé] / Jyothi C. Abbar, Auteur ; Sharanappa T. Nandibewoor, Auteur . - 2012 . - pp. 111-118. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 1 (Janvier 2012) . - pp. 111-118 Mots-clés : Human  Electrochemical  method Résumé : The electrochemical behavior of chlorzoxazone drug at glassy carbon electrode has been investigated for the first time using cyclic and square wave voltammetric techniques. The dependence of the current on pH, concentration, and scan rate was investigated to optimize the experimental conditions for determination ofchlorzoxazone. The anodic peak was characterized and the process was diffusion-controlled. The number of electrons transferred in the oxidation process was calculated and a plausible oxidation mechanism was proposed. In the range of 8.0 x 10―7 to 1.0 x 10―5 M, the current measured by square wave voltammetry presents a good linear property as a function of the concentration of chlorzoxazone with a detection limit of 4.41 x 10―8 M with good selectivity and sensitivity. The proposed method was successfully applied to chlorzoxazone determination under physiological condition in pharmaceutical samples and for the detection of chlorzoxazone in human biological fluids. This method can be employed in clinical analysis, quality control, and routine determination of drugs in pharmaceutical formulations. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=25476452

Electrochemical behavior of 4-aminophenazone drug at a graphite pencil electrode and its application in real samples / Jayant I. Gowda in Industrial & engineering chemistry research, Vol. 51 N° 49 (Décembre 2012) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 51 N° 49 (Décembre 2012) . - pp. 15936-15941 Titre : Electrochemical behavior of 4-aminophenazone drug at a graphite pencil electrode and its application in real samples Type de document : texte imprimé Auteurs : Jayant I. Gowda, Auteur ; Sharanappa T. Nandibewoor, Auteur Année de publication : 2013 Article en page(s) : pp. 15936-15941 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Electrodes Résumé : An analytical method for the determination of 4-aminophenazone using cyclic and differential-pulse voltammetry has been developed. The oxidation process was shown to be irreversible over the pH range 3.0―11.2. The dependence of the current on pH, concentration, and scan rate was investigated to optimize the experimental conditions for the determination of 4-aminophenazone. The number of electrons transferred in the oxidation process was calculated, and a probable oxidation mechanism was proposed. In the range of ( 1.0 X 10―6)―(1.6 X 10―5) M, the current measured by differential-pulse voltammetry as a function of the concentration of 4-aminophenazone with a detection limit of 0.458 × 10―7 M with good selectivity and sensitivity exhibited a good linear relationship. The proposed method was applied to the determination of 4-aminophenazone in a real sample. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26732119 [article] Electrochemical behavior of 4-aminophenazone drug at a graphite pencil electrode and its application in real samples [texte imprimé] / Jayant I. Gowda, Auteur ; Sharanappa T. Nandibewoor, Auteur . - 2013 . - pp. 15936-15941. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 51 N° 49 (Décembre 2012) . - pp. 15936-15941 Mots-clés : Electrodes Résumé : An analytical method for the determination of 4-aminophenazone using cyclic and differential-pulse voltammetry has been developed. The oxidation process was shown to be irreversible over the pH range 3.0―11.2. The dependence of the current on pH, concentration, and scan rate was investigated to optimize the experimental conditions for the determination of 4-aminophenazone. The number of electrons transferred in the oxidation process was calculated, and a probable oxidation mechanism was proposed. In the range of ( 1.0 X 10―6)―(1.6 X 10―5) M, the current measured by differential-pulse voltammetry as a function of the concentration of 4-aminophenazone with a detection limit of 0.458 × 10―7 M with good selectivity and sensitivity exhibited a good linear relationship. The proposed method was applied to the determination of 4-aminophenazone in a real sample. ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=26732119

Kinetic and mechanistic investigations of oxidation of pentoxifylline drug by alkaline permanganate / Rajesh N. Hegde in Industrial & engineering chemistry research, Vol. 48 N° 15 (Août 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N° 15 (Août 2009) . - pp. 7025–7031 Titre : Kinetic and mechanistic investigations of oxidation of pentoxifylline drug by alkaline permanganate Type de document : texte imprimé Auteurs : Rajesh N. Hegde, Auteur ; Nagaraj P. Shetti, Auteur ; Sharanappa T. Nandibewoor, Auteur Année de publication : 2009 Article en page(s) : pp. 7025–7031 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Hemorheologic  drug  Pentoxifylline  Alkaline  permanganate Résumé : The kinetics of oxidation of a hemorheologic drug, pentoxifylline by permanganate in alkaline medium at a constant ionic strength of 0.10 mol dm−3 was studied spectrophotometrically using a rapid kinetic HI-TECH SFA-12 accessory. The reaction between permanganate and pentoxifylline in alkaline medium exhibits 1:2 stoichiometry (pentoxifylline/permanganate). The reaction is of first order in [permanganate ion] and less than unit order dependence each in [PTX] and [OH−]. However, the orders in [PTX] and [OH−] changes from first order to zero order as their concentrations increase. A decrease in the dielectric constant of the medium increases the rate of the reaction. The effect of added products and ionic strength of the reaction medium have been investigated. The oxidation reaction in alkaline medium has been shown to proceed via a permanganate-pentoxifylline complex, which decomposes slowly in a rate-determining step followed by a fast step to give the products. A suitable mechanism is proposed. The main products were identified by TLC and spectral studies including LC−MS. The reaction constants involved in the different steps of the mechanism are calculated. The activation parameters with respect to slow step of the mechanism are computed and discussed and thermodynamic quantities are also determined. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9004145 [article] Kinetic and mechanistic investigations of oxidation of pentoxifylline drug by alkaline permanganate [texte imprimé] / Rajesh N. Hegde, Auteur ; Nagaraj P. Shetti, Auteur ; Sharanappa T. Nandibewoor, Auteur . - 2009 . - pp. 7025–7031. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 15 (Août 2009) . - pp. 7025–7031 Mots-clés : Hemorheologic  drug  Pentoxifylline  Alkaline  permanganate Résumé : The kinetics of oxidation of a hemorheologic drug, pentoxifylline by permanganate in alkaline medium at a constant ionic strength of 0.10 mol dm−3 was studied spectrophotometrically using a rapid kinetic HI-TECH SFA-12 accessory. The reaction between permanganate and pentoxifylline in alkaline medium exhibits 1:2 stoichiometry (pentoxifylline/permanganate). The reaction is of first order in [permanganate ion] and less than unit order dependence each in [PTX] and [OH−]. However, the orders in [PTX] and [OH−] changes from first order to zero order as their concentrations increase. A decrease in the dielectric constant of the medium increases the rate of the reaction. The effect of added products and ionic strength of the reaction medium have been investigated. The oxidation reaction in alkaline medium has been shown to proceed via a permanganate-pentoxifylline complex, which decomposes slowly in a rate-determining step followed by a fast step to give the products. A suitable mechanism is proposed. The main products were identified by TLC and spectral studies including LC−MS. The reaction constants involved in the different steps of the mechanism are calculated. The activation parameters with respect to slow step of the mechanism are computed and discussed and thermodynamic quantities are also determined. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie9004145

Kinetics and mechanism of permanganate oxidation of clopidogrel hydrogen sulfate / Kirthi S. Byadagi in Industrial & engineering chemistry research, Vol. 50 N° 19 (Octobre 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 19 (Octobre 2011) . - pp. 10962-10971 Titre : Kinetics and mechanism of permanganate oxidation of clopidogrel hydrogen sulfate : an antiplatelet drug in acid perchlorate solutions Type de document : texte imprimé Auteurs : Kirthi S. Byadagi, Auteur ; Rajeshwari V. Hosahalli, Auteur ; Sharanappa T. Nandibewoor, Auteur Année de publication : 2011 Article en page(s) : pp. 10962-10971 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Oxidation  Kinetics Résumé : The oxidation of dopidogrel hydrogen sulfate, commercially known as Plavix, by permanganate ion in aqueous perchloric acid medium at a constant ionic strength (1 = 0.06 mol dm―3) has been investigated spectrophotometrically at 526 nm. The reaction between clopidogrel hydrogen sulfate and permanganate in acid medium exhibits a 5:4 stoichiometry. The identified oxidation products, 4,5,6,7-tetrahydrothieno[3,2-c]pyridine, (2-chlorophenyl)oxoacetic acid, and formaldehyde as a byproduct, are different from those obtained by biological metabolism. The reaction is first-order in MnO4― and less than first-order in both the clopidogrel hydrogen sulfate and H+ ion concentrations. The active species of permanganate was found to be HMnO4. The oxidation reaction in acid medium was found to proceed through a permanganate―clopidogrel complex that decomposes slowly in a rate-determining step followed by other fast steps to give the products. The main products were identified by spot test and IR and GC-MS spectral studies. The reaction constants involved in different steps of the mechanism were calculated at different temperatures. The activation parameters with respect to the slow step of the mechanism were computed, and thermodynamic quantities were also determined. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24573291 [article] Kinetics and mechanism of permanganate oxidation of clopidogrel hydrogen sulfate : an antiplatelet drug in acid perchlorate solutions [texte imprimé] / Kirthi S. Byadagi, Auteur ; Rajeshwari V. Hosahalli, Auteur ; Sharanappa T. Nandibewoor, Auteur . - 2011 . - pp. 10962-10971. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 19 (Octobre 2011) . - pp. 10962-10971 Mots-clés : Oxidation  Kinetics Résumé : The oxidation of dopidogrel hydrogen sulfate, commercially known as Plavix, by permanganate ion in aqueous perchloric acid medium at a constant ionic strength (1 = 0.06 mol dm―3) has been investigated spectrophotometrically at 526 nm. The reaction between clopidogrel hydrogen sulfate and permanganate in acid medium exhibits a 5:4 stoichiometry. The identified oxidation products, 4,5,6,7-tetrahydrothieno[3,2-c]pyridine, (2-chlorophenyl)oxoacetic acid, and formaldehyde as a byproduct, are different from those obtained by biological metabolism. The reaction is first-order in MnO4― and less than first-order in both the clopidogrel hydrogen sulfate and H+ ion concentrations. The active species of permanganate was found to be HMnO4. The oxidation reaction in acid medium was found to proceed through a permanganate―clopidogrel complex that decomposes slowly in a rate-determining step followed by other fast steps to give the products. The main products were identified by spot test and IR and GC-MS spectral studies. The reaction constants involved in different steps of the mechanism were calculated at different temperatures. The activation parameters with respect to the slow step of the mechanism were computed, and thermodynamic quantities were also determined. DEWEY : 660 ISSN : 0888-5885 En ligne : http://cat.inist.fr/?aModele=afficheN&cpsidt=24573291

Mechanistic investigation of uncatalyzed and osmium(VIII) catalyzed oxidation of guanidine by Ag(III) periodate complex in aqueous alkaline medium / Jyothi C. Abbar in Industrial & engineering chemistry research, Vol. 48 N° 16 (Août 2009) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 48 N° 16 (Août 2009) . - pp. 7550–7560 Titre : Mechanistic investigation of uncatalyzed and osmium(VIII) catalyzed oxidation of guanidine by Ag(III) periodate complex in aqueous alkaline medium : a comparative kinetic approach Type de document : texte imprimé Auteurs : Jyothi C. Abbar, Auteur ; Shekappa D. Lamani, Auteur ; Sharanappa T. Nandibewoor, Auteur Année de publication : 2009 Article en page(s) : pp. 7550–7560 Note générale : Chemical engineering Langues : Anglais (eng) Mots-clés : Guanidine  hydrochlorid  Diperiodatoargentate(III)  Catalyzed  oxidation Résumé : The oxidation of guanidine hydrochloride (GH) by diperiodatoargentate(III) (DPA) has been investigated both in the absence and presence of [Os(VIII)] catalyst in alkaline medium at a constant ionic strength of 0.10 mol dm−3 spectrophotometrically. The oxidation products were identified by spectral studies. The stiochiometry was same in both the cases, i.e., [GH]/[DPA] = 1:1. In both the catalyzed and uncatalyzed cases, the order of the reaction with respect to [DPA] was unity while the order with respect to [GH] was <1 over the concentration range studied. The rate increased with an increase in [OH−] and decreased with an increase in [IO4−]. The order with respect to [Os(VIII)] was unity. Suitable mechanisms were proposed. The reaction constants involved in the different steps of the reaction mechanisms were calculated for both reactions. Kinetic experiments suggest that [Ag(H2IO6)(H2O)2] is the reactive silver(III) species and [OsO4(OH)2]2− is the reactive Os(VIII) species. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900691z [article] Mechanistic investigation of uncatalyzed and osmium(VIII) catalyzed oxidation of guanidine by Ag(III) periodate complex in aqueous alkaline medium : a comparative kinetic approach [texte imprimé] / Jyothi C. Abbar, Auteur ; Shekappa D. Lamani, Auteur ; Sharanappa T. Nandibewoor, Auteur . - 2009 . - pp. 7550–7560. Chemical engineering Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 48 N° 16 (Août 2009) . - pp. 7550–7560 Mots-clés : Guanidine  hydrochlorid  Diperiodatoargentate(III)  Catalyzed  oxidation Résumé : The oxidation of guanidine hydrochloride (GH) by diperiodatoargentate(III) (DPA) has been investigated both in the absence and presence of [Os(VIII)] catalyst in alkaline medium at a constant ionic strength of 0.10 mol dm−3 spectrophotometrically. The oxidation products were identified by spectral studies. The stiochiometry was same in both the cases, i.e., [GH]/[DPA] = 1:1. In both the catalyzed and uncatalyzed cases, the order of the reaction with respect to [DPA] was unity while the order with respect to [GH] was <1 over the concentration range studied. The rate increased with an increase in [OH−] and decreased with an increase in [IO4−]. The order with respect to [Os(VIII)] was unity. Suitable mechanisms were proposed. The reaction constants involved in the different steps of the reaction mechanisms were calculated for both reactions. Kinetic experiments suggest that [Ag(H2IO6)(H2O)2] is the reactive silver(III) species and [OsO4(OH)2]2− is the reactive Os(VIII) species. En ligne : http://pubs.acs.org/doi/abs/10.1021/ie900691z

Mechanistic study on the oxidation of sulfacetamide by aqueous alkaline diperiodatoargentate(III) / Suresh D. Kulkarni in Industrial & engineering chemistry research, Vol. 48 N°2 (Janvier 2009) 

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Oxidation of 6 - aminopenicillanic acid by diperiodatoargantate (III) in aqueous alkaline medium / Shridhar D. Gunagi in Industrial & engineering chemistry research, Vol. 49 N° 20 (Octobre 2010) 

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