Documents disponibles écrits par cet auteur

Microwave - assisted extraction of forskolin from coleus roots and its purification by adsorptive separation using functionalized polymer designed by molecular simulation / Leena P. Devendra in Industrial & engineering chemistry research, Vol. 49 N° 19 (Octobre 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 19 (Octobre 2010) . - pp. 9271–9278 Titre : Microwave - assisted extraction of forskolin from coleus roots and its purification by adsorptive separation using functionalized polymer designed by molecular simulation Type de document : texte imprimé Auteurs : Leena P. Devendra, Auteur ; Vilas G. Gaikar, Auteur Année de publication : 2010 Article en page(s) : pp. 9271–9278 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Microwave  Adsorptive  separation  Molecular  simulation Résumé : The extraction of forskolin from Coleus forskohlii roots using organic solvents was facilitated by irradiation of the raw material by microwave and studied for effect of time of irradiation, power level and water soaking of the raw material prior to irradiation on the rate of extraction. Methanol gave 92% extraction of forskolin after 2 min of the irradiation at 160 W under optimized conditions, with simultaneous increase in the rate of extraction. Molecular modeling approach was taken to design a specific adsorbent for selective adsorption of forskolin analogues from the complex extract. The forskolin analogues showed greater affinity toward a diethanolamine-loaded polymer as compared to forskolin. The purification of forskolin by adsorption on diethanolamine substituted polystyrene validated the predictions from molecular simulation. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie100495u [article] Microwave - assisted extraction of forskolin from coleus roots and its purification by adsorptive separation using functionalized polymer designed by molecular simulation [texte imprimé] / Leena P. Devendra, Auteur ; Vilas G. Gaikar, Auteur . - 2010 . - pp. 9271–9278. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 19 (Octobre 2010) . - pp. 9271–9278 Mots-clés : Microwave  Adsorptive  separation  Molecular  simulation Résumé : The extraction of forskolin from Coleus forskohlii roots using organic solvents was facilitated by irradiation of the raw material by microwave and studied for effect of time of irradiation, power level and water soaking of the raw material prior to irradiation on the rate of extraction. Methanol gave 92% extraction of forskolin after 2 min of the irradiation at 160 W under optimized conditions, with simultaneous increase in the rate of extraction. Molecular modeling approach was taken to design a specific adsorbent for selective adsorption of forskolin analogues from the complex extract. The forskolin analogues showed greater affinity toward a diethanolamine-loaded polymer as compared to forskolin. The purification of forskolin by adsorption on diethanolamine substituted polystyrene validated the predictions from molecular simulation. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie100495u

Purification of forskolin by adsorptive separation using functionalized polymer bearing specific ligands designed by molecular simulation / Leena P. Devendra in Industrial & engineering chemistry research, Vol. 50 N° 20 (Octobre 2011) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 50 N° 20 (Octobre 2011) . - pp. 11667–11676 Titre : Purification of forskolin by adsorptive separation using functionalized polymer bearing specific ligands designed by molecular simulation Type de document : texte imprimé Auteurs : Leena P. Devendra, Auteur ; Vilas G. Gaikar, Auteur Année de publication : 2011 Article en page(s) : pp. 11667–11676 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Adsorption  Molecular  modeling Résumé : The adsorption of forskolin and its analogues has been studied, a priori, by molecular modeling to design a suitable adsorbent for selective adsorption of forskolin from a complex extract. Ligands selective for forskolin have been designed on the basis of two-point attachments with forskolin so as to have desired selectivity. Dynamic adsorption and desorption experiments were conducted to establish the optimum parameters for the purification process using a functionalized polymer. After a single adsorption and desorption cycle, the purity of the forskolin increased to 98% using phenyl glycine-p-sulfonic acid substituted polystyrene as a functionalized polymer. Experimental verification of the selectivity of the ligand toward forskolin was successfully achieved. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie2004175 [article] Purification of forskolin by adsorptive separation using functionalized polymer bearing specific ligands designed by molecular simulation [texte imprimé] / Leena P. Devendra, Auteur ; Vilas G. Gaikar, Auteur . - 2011 . - pp. 11667–11676. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 20 (Octobre 2011) . - pp. 11667–11676 Mots-clés : Adsorption  Molecular  modeling Résumé : The adsorption of forskolin and its analogues has been studied, a priori, by molecular modeling to design a suitable adsorbent for selective adsorption of forskolin from a complex extract. Ligands selective for forskolin have been designed on the basis of two-point attachments with forskolin so as to have desired selectivity. Dynamic adsorption and desorption experiments were conducted to establish the optimum parameters for the purification process using a functionalized polymer. After a single adsorption and desorption cycle, the purity of the forskolin increased to 98% using phenyl glycine-p-sulfonic acid substituted polystyrene as a functionalized polymer. Experimental verification of the selectivity of the ligand toward forskolin was successfully achieved. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie2004175