| Titre : | Hydrogenation of amino acid mixtures to amino alcohols (2008) |
| Auteurs : | Ketan P. Pimparkar, Éditeur scientifique ; Dennis J. Miller, Éditeur scientifique ; James E. Jackson, Éditeur scientifique |
| Type de document : | Article : texte imprimé |
| Dans : | Industrial & engineering chemistry research (Vol. 47 N°20, Octobre 2008) |
| Article en page(s) : | P. 7648-7653 |
| Note générale : | Chemical engineering |
| Langues : | Anglais |
| Tags : | Amino acid alcohols |
| Résumé : | Amino alcohols are important building blocks for a variety of pharmaceutical, insecticidal, and other specialty compounds. Hydrogenation of amino acids to amino alcohols is a route that allows for the incorporation of biorenewable-derived chemicals into traditional petroleum-based industrial processes. This study examines the effect of multiple substrates on aqueous-phase hydrogenation rates of the amino acids serine, alanine, and valine. Hydrogenation reactions were carried out in a high-pressure reactor at 7.0 MPa hydrogen pressure and 130 °C over carbon supported ruthenium catalyst. Samples taken at regular intervals and analyzed by high-performance liquid chromatography allowed calculation of conversion rates and product yields. In general, competition between the amino acid substrates results in reduced reaction rates relative to that for hydrogenation of a single amino acid substrate. Kinetics of mixed amino acid hydrogenation was modeled using a Langmuir−Hinshelwood-type mechanism with surface reaction as the rate-limiting step. |
| En ligne : | http://pubs.acs.org/doi/abs/10.1021/ie800351x |
