Novel pH - sensitive hydrogels prepared from the blends of poly(vinyl alcohol) with acrylic acid - graft - guar gum matrixes for isoniazid delivery / Anita G. Sullad in Industrial & engineering chemistry research, Vol. 49 N° 16 (Août 2010)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 49 N° 16 (Août 2010) . - pp. 7323–7329 Titre : Novel pH - sensitive hydrogels prepared from the blends of poly(vinyl alcohol) with acrylic acid - graft - guar gum matrixes for isoniazid delivery Type de document : texte imprimé Auteurs : Anita G. Sullad, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur Année de publication : 2010 Article en page(s) : pp. 7323–7329 Note générale : Industrial chemistry Langues : Anglais (eng) Mots-clés : Hydrogels Résumé : A novel type of pH-sensitive hydrogel blend of poly(vinyl alcohol) with acrylic acid-graft-guar gum has been prepared. Microspheres with a size of 10 μm were produced by the water-in-oil (w/o) emulsification method for investigating the controlled release of an antituberculosis drug, isoniazid. These novel carriers were analyzed for surface morphology, size, effect of pH, swelling, drug loading, and in vitro release of isoniazid in pH 1.2 and 7.4 media. The kinetics of drug release was analyzed using empirical equations. Release times of the drug were increased to 8 h from its nascent plasma half-life of 0.5−1.6 h. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie100389v [article] Novel pH - sensitive hydrogels prepared from the blends of poly(vinyl alcohol) with acrylic acid - graft - guar gum matrixes for isoniazid delivery [texte imprimé] / Anita G. Sullad, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur . - 2010 . - pp. 7323–7329. Industrial chemistry Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 16 (Août 2010) . - pp. 7323–7329 Mots-clés : Hydrogels Résumé : A novel type of pH-sensitive hydrogel blend of poly(vinyl alcohol) with acrylic acid-graft-guar gum has been prepared. Microspheres with a size of 10 μm were produced by the water-in-oil (w/o) emulsification method for investigating the controlled release of an antituberculosis drug, isoniazid. These novel carriers were analyzed for surface morphology, size, effect of pH, swelling, drug loading, and in vitro release of isoniazid in pH 1.2 and 7.4 media. The kinetics of drug release was analyzed using empirical equations. Release times of the drug were increased to 8 h from its nascent plasma half-life of 0.5−1.6 h. ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie100389v

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Novel semi - interpenetrating microspheres of dextran - grafted - acrylamide and poly (vinyl alcohol) for controlled release of abacavir sulfate / Anita G. Sullad in Industrial & engineering chemistry research, Vol. 50 N° 21 (Novembre 2011)  

Public ISBD [article]  inIndustrial & engineering chemistry research > Vol. 50 N° 21 (Novembre 2011) . - pp. 11778–11784 Titre : Novel semi - interpenetrating microspheres of dextran - grafted - acrylamide and poly (vinyl alcohol) for controlled release of abacavir sulfate Type de document : texte imprimé Auteurs : Anita G. Sullad, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur Année de publication : 2011 Article en page(s) : pp. 11778–11784 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Microspheres Dextran Résumé : A novel drug delivery system using semi-interpenetrating (semi-IPN) microspheres of dextran-grafted-acrylamide (Dex-g-AAm) and poly(vinyl alcohol) (PVA) was prepared in the size range of 80–100 μm by emulsion cross-linking for investigating controlled release (CR) of an anti-HIV agent, abacavir sulfate. The graft copolymer was confirmed by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The microspheres were characterized for morphology, swelling, and in vitro release of abacavir sulfate in pH 1.2 and 7.4 buffer media to display the effect of drug release in acidic and alkaline conditions. The kinetics of in vitro release was analyzed using the empirical equations to understand the nature of release mechanism. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie2006438 [article] Novel semi - interpenetrating microspheres of dextran - grafted - acrylamide and poly (vinyl alcohol) for controlled release of abacavir sulfate [texte imprimé] / Anita G. Sullad, Auteur ; Lata S. Manjeshwar, Auteur ; Tejraj M. Aminabhavi, Auteur . - 2011 . - pp. 11778–11784. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 50 N° 21 (Novembre 2011) . - pp. 11778–11784 Mots-clés : Microspheres Dextran Résumé : A novel drug delivery system using semi-interpenetrating (semi-IPN) microspheres of dextran-grafted-acrylamide (Dex-g-AAm) and poly(vinyl alcohol) (PVA) was prepared in the size range of 80–100 μm by emulsion cross-linking for investigating controlled release (CR) of an anti-HIV agent, abacavir sulfate. The graft copolymer was confirmed by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The microspheres were characterized for morphology, swelling, and in vitro release of abacavir sulfate in pH 1.2 and 7.4 buffer media to display the effect of drug release in acidic and alkaline conditions. The kinetics of in vitro release was analyzed using the empirical equations to understand the nature of release mechanism. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie2006438

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