Article : texte imprimé

Parameter estimation in batch bioreactor simulation using metabolic models : sequential solution with direct sensitivities

Juha T. Leppävuori, Auteur |

Dans Industrial & engineering chemistry research (Vol. 50 N° 21, Novembre 2011)

In this study, we propose a parameter estimation method for genome-scale dynamic flux balance (DFBA) models. A bilevel optimization problem is reformulated as a differential-algebraic equation (DAE) optimization problem and solved sequentially, [...]

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