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Supersaturation control and heterogeneous nucleation in membrane crystallizers / Gianluca Di Profio in Industrial & engineering chemistry research, Vol. 49 N° 23 (Décembre 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 23 (Décembre 2010) . - pp.11878–11889 Titre : Supersaturation control and heterogeneous nucleation in membrane crystallizers : facts and perspectives Type de document : texte imprimé Auteurs : Gianluca Di Profio, Auteur ; Efrem Curcio, Auteur ; Enrico Drioli, Auteur Année de publication : 2011 Article en page(s) : pp.11878–11889 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Heterogeneous  nucleation  Membrane  crystallizers Résumé : The interest to combine membrane operations and solution crystallization has grown in the past several years. This approach has been put into practice in several forms of membrane-assisted crystallization (MAC) processes, among which is membrane crystallization (MCr) technology. The main features of MCr are (1) the use of membranes as precision devices to control the composition of the crystallizing solution, by opposing a well-defined and tunable resistance to mass flow occurring in the vapor phase; (2) the action of the porous surface of the membrane as a suitable support to activate heterogeneous nucleation mechanisms; (3) the possibility to induce nucleation and crystal growth in separate sites, thus reducing the risk of membrane fouling even when the same membrane supports heterogeneous nucleation. Thanks to these fundamental options, combined together in a unique apparatus, advantages like (i) improved control of the supersaturation degree and the rate of its generation; (ii) the possibility for the crystallization to be initiated at low supersaturation levels; (iii) the enhancement of the crystallization kinetics; and (iv) improved overall process efficiency can be achieved, even for large and complex molecules like proteins. The most interesting developments and the more exciting perspectives for this novel technology have been reviewed in this paper. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie100418z [article] Supersaturation control and heterogeneous nucleation in membrane crystallizers : facts and perspectives [texte imprimé] / Gianluca Di Profio, Auteur ; Efrem Curcio, Auteur ; Enrico Drioli, Auteur . - 2011 . - pp.11878–11889. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 23 (Décembre 2010) . - pp.11878–11889 Mots-clés : Heterogeneous  nucleation  Membrane  crystallizers Résumé : The interest to combine membrane operations and solution crystallization has grown in the past several years. This approach has been put into practice in several forms of membrane-assisted crystallization (MAC) processes, among which is membrane crystallization (MCr) technology. The main features of MCr are (1) the use of membranes as precision devices to control the composition of the crystallizing solution, by opposing a well-defined and tunable resistance to mass flow occurring in the vapor phase; (2) the action of the porous surface of the membrane as a suitable support to activate heterogeneous nucleation mechanisms; (3) the possibility to induce nucleation and crystal growth in separate sites, thus reducing the risk of membrane fouling even when the same membrane supports heterogeneous nucleation. Thanks to these fundamental options, combined together in a unique apparatus, advantages like (i) improved control of the supersaturation degree and the rate of its generation; (ii) the possibility for the crystallization to be initiated at low supersaturation levels; (iii) the enhancement of the crystallization kinetics; and (iv) improved overall process efficiency can be achieved, even for large and complex molecules like proteins. The most interesting developments and the more exciting perspectives for this novel technology have been reviewed in this paper. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie100418z