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Industrial Production of tert-Butyl-4-oxoazepane-1-carboxylate / Yun-Sheng Huang in Industrial & engineering chemistry research, Vol. 49 N° 23 (Décembre 2010) 

Public ISBD [article]  in Industrial & engineering chemistry research > Vol. 49 N° 23 (Décembre 2010) . - pp. 12164–12167 Titre : Industrial Production of tert-Butyl-4-oxoazepane-1-carboxylate Type de document : texte imprimé Auteurs : Yun-Sheng Huang, Auteur ; Wen-Qing Zhang, Auteur ; Pei-Feng Zhang, Auteur Année de publication : 2011 Article en page(s) : pp. 12164–12167 Note générale : Chimie industrielle Langues : Anglais (eng) Mots-clés : Oxoazepane  Carboxylate Résumé : A large-scale process for the preparation of tert-butyl 4-oxoazepane-1-carboxylate (1), a useful intermediate for many pharmaceutical products under development, is described. This process is based on the ring expansion of tert-butyl piperid-4-one-1-carboxylate using ethyl diazoacetate. The entire process can be operated safely, less expensively, and conveniently without the necessary purification for any of the intermediates. The production scale of over 33 kg of the final product was achieved with good overall yield. The main focuses of optimization were the large-scale preparation of ethyl diazoacetate and the ring expansion at low temperature. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie101807g [article] Industrial Production of tert-Butyl-4-oxoazepane-1-carboxylate [texte imprimé] / Yun-Sheng Huang, Auteur ; Wen-Qing Zhang, Auteur ; Pei-Feng Zhang, Auteur . - 2011 . - pp. 12164–12167. Chimie industrielle Langues : Anglais (eng) in Industrial & engineering chemistry research > Vol. 49 N° 23 (Décembre 2010) . - pp. 12164–12167 Mots-clés : Oxoazepane  Carboxylate Résumé : A large-scale process for the preparation of tert-butyl 4-oxoazepane-1-carboxylate (1), a useful intermediate for many pharmaceutical products under development, is described. This process is based on the ring expansion of tert-butyl piperid-4-one-1-carboxylate using ethyl diazoacetate. The entire process can be operated safely, less expensively, and conveniently without the necessary purification for any of the intermediates. The production scale of over 33 kg of the final product was achieved with good overall yield. The main focuses of optimization were the large-scale preparation of ethyl diazoacetate and the ring expansion at low temperature. DEWEY : 660 ISSN : 0888-5885 En ligne : http://pubs.acs.org/doi/abs/10.1021/ie101807g